Background
: Oxidative stress is involved in the pathogenesis of many
diseases. Conditions of oxidative stress and antioxidant imbalance plays a
major role in the occurrence and development of atherosclerosis. The main
objective of this study is to evaluate serum levels of malondialdehyde (MDA) as
an index of lipid peroxidation and total antioxidant capacity (TAC) after consumption of atorvastatin in coronary artery stenosis patients.
Materials
and Methods: This study was carried out on 75 patients with angiographically
proven coronary artery stenosis. The patients with coronary
artery stenosis were divided into the following 3 groups according to consumption
duration of atorvastatin: 25 patients
were classified statins consume less than 6 days, 27 patients taking statins
for 6 to 90 days, and 23 patients taking statins for more than 90 days. The
levels of serum MDA and TAC were measured by thiobarbituric acid and
Benzie methods, respectively.
Results: The serum TAC concentrations of patients taking statins for more than 90
days(0.83 ± 0.101 mmol/l) were significantly increased (p=0.001) compared with
patients that atorvastatin consume less than 6 days (0. 686 ± 0.076 mmol/l) while
the levels of MDA decreased significantly (p<0.029), 0.472 ± 0.112 µmol/l
and 0.73 ± 0.43 µmol/l, respectively.
Conclusion: In conclusion, results indicate that a
significant reduction of plasma MDA levels as well as a significant enhancement of TAC in coronary artery stenosis patients with long time receiving atorvastatin contribute to the lowering oxidative stress in this patients.
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