Volume 19, Issue 1 (6-2017)                   yafte 2017, 19(1): 1-7 | Back to browse issues page


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Sari S. Analysis of Androgen Receptor Gene Mutations in female with infertility. yafte. 2017; 19 (1) :1-7
URL: http://yafte.lums.ac.ir/article-1-2473-en.html

Assistant Professor Department of Molecular and Cellular Sciences, Faculty of Advanced Sciences & Technology, Pharmaceutical Sciences Branch, Islamic Azad University, Tehran
Abstract:   (675 Views)

Background : Infertility is a multifactorial disease. Hormonal disorders and genetic factors are important in female infertility. Development and maturation of ovulation are depending on the molecular signaling pathways in response to androgens. Over hundreds of mutations leading to resistance gene function in androgen receptor (AR) has been recorded. One of them is polymorphic region 5'UTR. Thus regarding to the role of androgen receptor in infertility, the aim of the present study was to investigate the association between gene mutations AR and infertility in Iranian women

Materials and Methods: In this study of 50 infertile women and 80 healthy women as a control, blood samples were taken. After extraction of DNA, PCR method was used to determine the AR gene mutations.

Results: In the present study in '5UTR area at position +25 androgen receptor gene a T nucleotide deletion was observed. , therefore single nucleotide mutations did not change in the androgen receptor gene expression, so indicates the lack of communication between the AR gene mutations in the promoter region of 23 to 214+ in women with infertility. According to the results of this study are significant differences between the two groups of patients and healthy women was not found (P=0.5).

Conclusion: Results indicated no correlation between mutations in the promoter region of 23 to 214+ AR genes in the population studied women with infertility

Full-Text [PDF 206 kb]   (284 Downloads)    
Type of Study: Research |
Received: 2017/06/12 | Accepted: 2017/06/12 | Published: 2017/06/12

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