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Osali A, Choobineh S, Soori R, Ravasi A A, Mostafavi H. The Effect of Three-Month Aerobic Exercise with Moderate Intensity on IL1β, IL-6, and brain volume in 50-65 Years Old Women with Metabolic Syndrome . yafte 2017; 19 (2) :60-71
URL: http://yafte.lums.ac.ir/article-1-2545-en.html

Background:  The increasing of age, inflammatory factors¸ and metabolic syndrome are the effective reasons in the reduction of  brain volume. The aim of this research was to investigate the effect of twelve week aerobic exercise with moderate intensity on IL1β, IL-6, and brain volume in 50-65 years old women with metabolic  syndrome.
Materials and Methods: 24 women with Metabolic Syndrome (MetS) took a part voluntarily. They were divided into two groups, MetS exercise (EM), MetS control (CM). ME group participated in an aerobic exercise training (AT) program (for 12 weeks), three sessions per week, each session contained three performing parts and two relaxing parts, at the beginning, each part contained eight minutes. Also each week, one minute added to performing sets. MRI and blood samples were conducted before and after three month to evaluate the levels of IL1β, IL-6, and brain volume. Data were analyzed by paired-sample of T-Test, and independent samples of T-Test.
Results: Brain volume afterthree  month doesn't significantly changed, but IL1β, and IL-6 after tree month exercise were significantly decreased (P<0.05). Also, there were not significantly different in brain volume, IL1β, and IL-6 pre and post test in the control group.
Conclusion: These findings indicate that three months aerobic exercise with a moderate intensity ameliorate inflammatory factor and doesn't change brain volume. Maybe with adjusting, the time and intensity of exercise brain volume will be increased.