Background: The steroidal alkaloids incurring great interest because of their various pharmacological properties that isolated from various species. The aim of this investigation has been to studying of the effects of Steroidal alkaloids isolated from olive leaf on cerebral ischemic – induced inury on rats. Materials and methods: In this experimental study, 48 male wistar rats divided to six groups of eight. Then cerebral ischemia- reperfusion injury produced by 10 min bilateral occlusion of the common carotid and vertebral artery, followed by 5 day reperfusion. Findings: Intravenous setroidal alkaloids isolated from olive leaf (0.5 , 1 , 1.5 mg.kg) markdly reduced the stroke index, enhanced the recovery of EEG (Electroencephalogram) amplitude during reperfusion and decreased the concentration of cortex calcium and LPO (lipid peroxidase) in a dose dependent manner. However, no significant effects on water and sodium contents were observed . Conclusions: These results suggested that steroidal alkaloids exhibited protective effects on cerebral ischemia – reperfusion injury in rats, and its mechanism might be related to reducing calcium accumulation and lipid peroxidation

Keywords: Steroidal alkaloids, Cerebral ischemia-reperfusion, Electroencephalogram, Lipid peroxidase

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