Background : Nephropathy is a common complication of diabetes and it is the major cause of disability and death among these patients. We aimed to determine the effects of soy milk on inflammation, coagulation and oxidative stress among type 2 diabetic patients with nephropathy. Methods: This randomized crossover controlled clinical trial was conducted on type 2 diabetic patients with nephropathy. This study had two trial phases, each for 4 weeks and one washout period for two weeks. Patients were randomly assigned to consume a diet containing soy milk, or a diet containing cow’s milk. Results: Soy milk consumption, in comparison to cow’s milk, resulted in a significant reduction in D-dimer level. This significant effect remained even after adjustment of cofounding factor (carbohydrate intake). However, soy milk consumption had no significant effects on inflammation and oxidative stress levels. Conclusion: Soy milk consumption for 4 weeks could decrease serum D-dimer level in type 2 diabetic patients with nephropathy.

Keywords: Soy milk, Diabetic nephropathy, Inflammation, Coagulation, Oxidative stress.

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