Volume 16, Issue 4 (2-2015)                   yafte 2015, 16(4): 36-43 | Back to browse issues page

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, Faculty of Medicine, Lorestan University of Medical Sciences, Khoramabad, Iran
Abstract:   (4082 Views)
Background: The prevalence of diabetes is rising in the world. The aim of this study was to determine the possible protective effect of sodium selenite on serum lipid profile and atherogenic indexes in Alloxan-induced Type 1 diabetic rats. Materials and Methods: Forty Sprage-dawley male rats were divided into four groups randomly group one, as control, group two, sham (control treated with sodium selenite (1mg/kg)), group three, diabetic untreated, and group four, treated with sodium selenite (1mg/kg), respectively. Diabetes was induced in the second and third groups by alloxan injection subcutaneously. After 8 weeks, animals were anaesthetized, blood samples were also collected before killing to measure the blood glucose, triglyceride, cholesterol, LDL, VLDL, HDL and serum atherogenic indexes. Results: Sdium selenite inhibited a significant decrease of BG, TG, C, LDL and VLDL. HDL level. Sodium selenite inhibited significantly serum atherogenic indexes level. Conclusion: This study showed that sodium selenite exerts beneficial effects on the BG, lipid profile and atherogenic indexes in alloxan-induced Type 1 diabetic rats.
Full-Text [PDF 190 kb]   (1119 Downloads)    
Type of Study: Research |
Received: 2015/02/10 | Accepted: 2015/02/10 | Published: 2015/02/10