Background: Academic performance indicates the success of an educational system in each community in targeting and paying attention to individual needs. Therefor, the educational system can be efficient when their academic performance of students has the highest and highest rates in different periods.
Materials and methods: The research method was descriptive - correlation. The statistical population consisted of studying students of Engineering- Technical and Humanities sciences at Islamic Azad University, Khorramabad branch in 2015-2016 academic year that were 7761 people. Sample size  determined 351 people by Kerjci-Morghan table and selected by stratified method. The data collection tool was Coopersmith Self-Esteem Scale (1967), Beck Depression Inventory (1996) and the scores  average of the students. For data analysis was used indicators as Frequency, frequency percentage, mean and standard deviation and tests as Pearson correlation coefficient and stepwise multiple regression.
Findings: The results showed that, there is a negative and significant relationship between depression and  academic performance of students,  positive and significant relationship between self-esteem and its dimensions (between public self-esteem, family self-esteem, social self-esteem and academic self-esteem) and academic. Also, based on the results of regression analysis, family self-esteem, depression and academic self-esteem, 8% from variance in the  academic performance of participating students scores in the research is explained.
Results: This research conducted in order to survey the  relationship between self-esteem and depression with academic performance and also multiple regression analysis of their relationships  Conclusion: Considering the importance of educational performance and depression and self-esteem as its related variables.