Volume 20, Issue 3 (10-2018)                   yafte 2018, 20(3): 90-99 | Back to browse issues page

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Department of Mental Health Nursing, Faculty of Nursing and Midwifery, Tehran Medical Science Branch, Islamic Azad University, Tehran. Iran
Abstract:   (1936 Views)
Background: Alzheimerchr('39')s disease is a multi-factorial disorder. The genes involved in Alzheimerchr('39')s disease act as risk factors. The aim of this study was to investigate the APOE gene polymorphism in patients with Alzheimerchr('39')s disease in Iran.
Materials and Methods: In this analytical-descriptive study, 50 patients with Alzheimerchr('39')s were investigated. Polymorphism of the APOE gene was investigated in healthy subjects and patients with Alzheimerchr('39')s using Tetra Arms PCR.
Results: The frequency of the 4ε /4ε genotype and ε4 allele was significantly higher in patients with Alzheimerchr('39')s compared to healthy subjects (38/4% and57/4% versus 3/8% and 28/8%, respectively) (P≥0.009).
Conclusion: In polymorphism of the APOE gene, the 4ε /4ε genotype, and the ε4 allele, are risk factors for Alzheimerchr('39')s disease in the Iranian population.
Full-Text [PDF 375 kb]   (531 Downloads)    
Type of Study: Research | Subject: علوم آزمایشگاهی
Received: 2017/06/15 | Accepted: 2018/11/20 | Published: 2019/01/14