Volume 20, Issue 3 (10-2018)                   yafte 2018, 20(3): 9-18 | Back to browse issues page

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Ashoori M, Nezhadali M, Shiehmorteza M. The relationship between visfatin levels and Anthropometric parameters, and insulin resistance in women with prediabetes and type 2 diabetes. yafte 2018; 20 (3) :9-18
URL: http://yafte.lums.ac.ir/article-1-2641-en.html
Department of Biology,Islamshahr Branch, Islamic Azad University, Islamshahr, Iran
Abstract:   (4683 Views)
Background: Visfatin is a protein secreted by visceral fat, which plays an important role in the pathogenesis of type 2 diabetes mellitus. Visfatin is also known as Pre-B Cell Colony Enhancing Factor or Nicotinamide Phosphoribosyl Transferase.  Visfatin is widely expressed in the visceral adipose tissue and has insulin-like metabolic functions. However, its pathophysiological role in human is still unknown. The aim of this study was to evaluate the relationship between plasma visfatin and obesity, and type 2 diabetes.
Materials and Methods: This case-control study was conducted on 50 women with pre-diabetes and type 2 diabetes, and 50 healthy women. Visfatin and insulin levels were measured using a Mercodia ELISA kit (Mercodia Company, Sweden). The weight, height, waist circumference and FBS were determined using standard methods. Data was analyzed using SPSS software (Version 19).
Results: According to the data, plasma visfatin levels increased in patients with prediabetes and type 2 diabetes compared to the control group (p<0/05). There was a meaningful correlation between visfatin and BMI, weight, waist circumference and HOMA-IR (p<0/05). No correlation was found between visfatin and FBS, and insulin in patients with prediabetes and type 2 diabetes.
Conclusion: These results suggest that visfatin levels correlate with BMI, weight, and waist circumference, and can be used as a marker for the diagnosis and treatment of type 2 diabetes.
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Type of Study: Research | Subject: علوم آزمایشگاهی
Received: 2018/02/26 | Accepted: 2019/01/5 | Published: 2019/01/14

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