Volume 13, Issue 1 (6-2011)                   yafte 2011, 13(1): 63-76 | Back to browse issues page

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Faculty of Medicine Lorestan University of Medical Sciences, Khorramabad, Iran .
Abstract:   (9671 Views)

Antisperm antibodies (ASA) occur in men and women and may significantly impair fertility. In this case, the testis is an immunologically privileged site where germ cell antigens are protected from autoimmune attack. However, due to disruption of the blood-testis barrier occurring from testicular injury, or as a consequence of trauma to the epididymis or vas deferens many testicular proteins get autoantigenic during immunological challenges resulting in the formation of ASA in the blood serum, seminal plasma or located on the sperm membrane. ASA have also been reported to be associated with inflammation, cryptorchidism, varicocele and surgical intervention in the genital organs. ASA may interfere with different sperm functions, which are essential for the fertilization process.This review article will help to increase our understanding of the specific mechanisms that elicit the autoimmune response to sperm and of the pathogenesis of ASA that leads to an antibody-mediated infertility.

Full-Text [PDF 1367 kb]   (2081 Downloads)    
Type of Study: Research |
Received: 2011/06/13 | Accepted: 2017/06/3 | Published: 2017/06/3