Introduction: The precise mechanism for antisperm antibody (ASA) mediated fertility impairment is unclear. In the male reproductive tract, ASA may have an adverse impact on sperm maturation and function or overall semen quality. In this study, the percentage of ASA-IgA was determined by the direct Mixed Agglutination Reaction (MAR) test in men from infertile couples in Khorramabad city. Furthermore, the semen parameters were evaluated in order to examine any correlation with the presence of ASA. Materials and Methods:85 men were tested for ASA as a part of an infertility evaluation. Patients were grouped according to percentage of ASA of < 10%. Or 10%. Semen parameters (Volume less than 2ml, concentration less than 20×106/ ml, and motility less than 50%) were calculated for each group. Statistical analysis was performed using Fisher’s exact test. Results: Results showed that 20% of this population were ASA-positive. Volume less than 2ml was not associated with ASA by direct MAR (P = 0.56). Concentration less than 20×106/ml was not associated with ASA by direct MAR. Motility less than 50% was significantly associated with ASA by direct MAR (P = 0.005). Conclusion: Antisperm antibodies can disrupt normal sperm function by damaging sperm motility. Therefore, it can be suggest that patients with sperm motility than 50% should become Candidate of ASA assay.

Keywords: Antisperm antibody, semen parameters, mixed agglutination reaction

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