A Case Report of Anesthetic Management of Two Patients with Epidermolysis Bolusa Rahimzadeh P1, Etemadi H1, Hassani V2, Mirdehghan MH3 1. Assistant Professor, Department of Anesthesiology, Faculty of Medicine, Iran University of Medical Sciences 2. Professor, Department of Anesthesiology, Faculty of Medicine, Iran University of Medical Sciences 3. Resident of Anesthesiology, Iran University of Medical Sciences Abstract Background: Epidermolysis Bolusa is a great challenge for all anesthesiologists. In this disease even indirect touch and pressure can cause boluses or wounds on skin and membranes of body. Case report: In this paper we introduce two Epidermolysis Bolusa patients who were brought to the operation room for the amnion graft of finger fusion. Conclusion: For anesthetic management of these patients, when surgery does not need muscle relaxation and mechanical ventilation, Ketamine is recommended for the prevention of airway manipulation. Key words: Epidermolysis Bolusa, bolus, graft