@ARTICLE{Mousavi, author = {Shahsavar, Farhad and Mousavi, Tahereh and Entezami, Kobra and Azargoon, Ali reza and }, title = {Association of KIR-HLA interactions with diseases}, volume = {13}, number = {3}, abstract ={The killer cell immunoglobulin-like receptors (KIR) are a recently discovered family of activating and inhibitory receptors which control natural killer (NK) cell function. KIR exist as a diverse family of receptors that have evolved rapidly by both gene duplication and recombination events. These findings were unexpected for a family of genes involved primarily in the innate immune response. Human leukocyte antigen (HLA) class I molecules serve as ligands for the KIR. Several disease association studies indicate a role for interactions between these loci in infectious diseases, autoimmune/inflammatory disorders, cancer and reproduction. Emerging functional data supports a mechanism based on a continuum of inhibition to activation through various compound KIR-HLA genotypes in diseases. This review summarizes the major features of these genes and discusses how they may be involved in both disease pathogenesis and its amelioration. }, URL = {http://yafte.lums.ac.ir/article-1-566-en.html}, eprint = {http://yafte.lums.ac.ir/article-1-566-en.pdf}, journal = {scientific magazine yafte}, doi = {}, year = {2011} }