AU - Mosayebi, ghasem AU - Ghazavi, ali AU - Salehi, hosein TI - Effect of vitamin D3 on leukocyte infiltration into the brain of C57/BL6 mice with experimental autoimmune encephalomyelitis PT - JOURNAL ARTICLE TA - Yafteh JN - Yafteh VO - 8 VI - 3 IP - 3 4099 - http://yafte.lums.ac.ir/article-1-1030-en.html 4100 - http://yafte.lums.ac.ir/article-1-1030-en.pdf SO - Yafteh 3 AB  - Background: Leukocyte infiltration into the central nervous system (CNS) in diseases like multiple sclerosis (MS) and experimental autoimmune encephalomyelitis (EAE) have been implicated in subsequent disease pathogenesis and progression. It suggested that vitamin D3 (active form of vitamin D) ameliorates the symptoms of EAE when administered after the onset of clinical sings. The aim of this study was to understand the efficacy of vitamin D3 against EAE, we examined the effect of vitamin D3 on the leukocyte infiltration into the brain of male C57BL/6 mice with MOG35-55- induced EAE. Material and methods: Male C57BL/6 mice were divided into two therapeutic groups (n=8 per group) with age and weight-matched as follow: Vitamin D3-treated EAE mice (5μg/kg/every two days of vitamin D3 given i.p.) from day -3 until day +19 after disease induction. Non-treated EAE mice (EAE control) received vehicle alone with same schedule. In addition, 5 age and weight-matched male C57BL/6 mice served as normal (non-EAE) controls. Results: Vitamin D3-treated mice had significantly less clinical score of EAE (3.2±0.8) than non-treated mice (5.3±0.44), (p CP - IRAN IN - LG - eng PB - Yafteh PG - 85 PT - Research YR - 2006