TY - JOUR JF - Yafteh JO - yafte VL - 8 IS - 1 PY - 2006 Y1 - 2006/6/01 TI - Effects of enalapril on diabetic neuropathy in rats TT - بررسی اثر انالاپریل بر نوروپاتی دیابتی در موش صحرائی N2 - Background: Neuropathy is one of the important complications of diabetes. Deficiency of the nerve conduction velocity (NCV) that occurs in both human diabetic neuropathy and animal diabetes models is one of the indicators for diabetic neuropathy. In the present study, we examined the effect of enalapril, angiotensinconverting enzyme inhibitor on NCV, number of endoneurial capillaries and thickness of the capillary basement membrane in motor sciatic nerves of diabetic and non diabetic rats. Materials and Methods: Fifty male rats, 300-450gr body weight, randomly divided into five equal groups (control, sham, diabetic, prevention and treatment). Diabetes was induced by subcutaneous injection of alloxan (140mg/kg). Body weight and fast blood sugar were measured at the beginning of experiment and every endweek during the course of experiment. Animals in the sham and prevention groups received enalapril orally (5mg/kg/day) since the beginning of the experiment for five weeks. Treatment group received enalapril (5mg/kg/day) for four weeks after five weeks without treatment. NCV in motor sciatic nerve was measured at the end of the period. Then, the number of capillaries and thickness of basement membranes in the endoneurium of the motor sciatic nerve in all groups were examined. Findings: NCV was reduced by 45% in diabetic rats compared with the control group (p SP - 3 EP - 11 AU - Tavakoli, asadollah AU - Delfan, bahram AU - Esmaili dahaj, mansour AD - KW - Diabetic neuropathy KW - Angiotensin converting enzyme inhibitor KW - Enalapril UR - http://yafte.lums.ac.ir/article-1-1046-en.html ER -