%0 Journal Article %A Seyed Alipour, bager %A Oshrieh, masoomeh %A Khanbabaee, ramezan %T The effect of ZnO Nps of 20 nm on changes of enzyme and liver tissues of pregnant NMRI mice %J scientific magazine yafte %V 16 %N 3 %U http://yafte.lums.ac.ir/article-1-1747-en.html %R %D 2015 %K Toxicity properties, ZnO Nps, Liver enzymes, Hepatocyte, %X Background :Nowadays, nanotechnology has been developing rapidly and may have considerable effects on industry, society and the environment. In this research the toxicity properties of zinc oxide nanoparticles with a size of 20 nm on enzyme and liver tissue of NMRI mice were studied. Materials and Methods: This experimental study was performed in standard conditions on 25 NMRI mice with an average weight of 30 ± 3 g so that they received different doses of zinc oxide nanoparticles, an a days, for 15 days intraperitoneally. Then, blood samples were taken on day 17 of NMRI mice. The collected tissues were washed with saline and fixed in Boin΄s fluied buffer and stained with hematoxylin and eosin for histopathology evaluation. After data collection, statistical analysis was done using SAS software. Results: The results showed that activity of ALT enzyme at concentrations 50, 100, 150 and 200 mg/kg ZnO Nps at a significant level (p %> http://yafte.lums.ac.ir/article-1-1747-en.pdf %P 85-92 %& 85 %! %9 Research %L A-10-1280-22 %+ Faculty of Basic Sciences, University of Mazandaran, Babolsar, Iran, b.alipour81@gmail.com %G eng %@ 1563-0773 %[ 2015