TY - JOUR T1 - The Role of Distinct Tumor Micro-Environments in the Heterogeneity of Metabolic Tumor Phenotypes TT - نقش میکرو محیط های مختلف تومور درگوناگونی فنوتیپ های متابولیک تومور JF - Yafteh JO - Yafteh VL - 21 IS - 4 UR - http://yafte.lums.ac.ir/article-1-2866-en.html Y1 - 2020 SP - 74 EP - 85 KW - Tumor microenvironments KW - metabolic phenotypes KW - Fatty acid oxidation KW - metabolic process N2 - Tumorigenesis is a complex and dynamic process. The microenvironment of tumors plays a pivotal role in the formation, initiation and progression of tumors. Studies on neoplastic developments focusing on tumor microenvironment events demonstrate its significance in promoting tumor progression. Prior to tumor metastasis, primary tumors secrete factors that create a proper metabolic environment for tumor metastasis. These conditions prepare the microenvironment for better and more efficient tumor growth. On the other hand, tumor cells continuously interact with the surrounding microenvironment, and targeting the tumor microenvironment can complement traditional treatment and improve the therapeutic outcomes for these malignancies. In the present article, the researchers attempt to highlight the importance of tumor microenvironment in tumorigenesis and tumor metabolism. M3 ER -