Background: The aim of this study was to investigate the relationship of familial history of gastrointestinal cancers and personal history of colon polyps with colorectal cancer incidence in khorramabad in 2012. Materials and Methods: This cross-sectional study included 50 patients with definite diagnosis of colon cancer based on colonoscopy and pathology in 2012. The control group included 56 persons from outpatients without a history of gastrointestinal diseases admitted to the skin and eye clinics of shohada ashayer hospital, who were matched with the patients for age and gender. The two groups were studied in terms of familial history of gastrointestinal diseases in immediate relatives and personal history of colorectal polyps using a self-constructed questionnaire. Fisher exact test and odds ratio estimate was used for data analysis. Results: The mean age of the patients was 52.8±15.5 years old, and 56% were male. A significant relationship was found between familial history of gastric and colon cancers in immediate relatives and colorectal cancer incidence in the patients (p<0.05). The odds ratio estimate of colorectal cancer incidence in the individuals with a positive history of gastric cancer and colon cancers in immediate relatives were respectively 3.96(CI=1.44-6.61) and 6.75 (CI=2.4-11.1) times of the estimate in the control individuals. No significant relationship was found between a history of esophageal cancers in immediate relatives with colon cancer incidence in the patients (p=0.61). Moreover, a significant relationship was found between a history of colon polyps and colorectal cancer incidence (p=0.004). Conclusion: The results of the present study should be confirmed in the further studies with larger sample sizes, so that serious measures to control the cancer can be taken through developing comprehensive prevention programs based on screening.

Keywords: Familial history, Gastrointestinal cancers, Colon polyps, Khorramabad

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