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Afrouzan H, Abouie Mehrizi A, Shokrgozar M A, Tahghighi A, Eshaghi A, Dinparast Dgadid N et al . Assessment of the cytotoxicity and in vivo anti-Plasmodial activity of ethanol and dichloromethane extracts of four different Iraninan propolis. yafte 2017; 19 (2) :115-125
URL: http://yafte.lums.ac.ir/article-1-2551-en.html

Background: The emergence of antimalarial drug resistance is one of the great problems of malaria control and elimination of worldwide. In order to overcome anti-malarial drug resistance, cytotoxicity and in vivo anti-Plasmodiumal activity of four different Iranian propolis were investigated.
Materials and Methods: Four Iranian propolis samples were collected from four different regions of Iran and extracted by %70 ethanol and dichloromethane. The cytotoxicity of ethanolic and dichloromethane extract of propolis, using L969 fibroblast cell lines, were evaluated by MTT assay. The in vitro anti-Plasmodial activities of the propolis samples on BALB/c mice were assayed.
Results:The cytotoxicity results showed that ethanol and dichloromethane extracts of four Iranian propolis samples at doses of 25, 50, 100 and 200 µg/ml were non-toxic (P<0.05). The highest percentage of growth inhibition against Plasmodium berghei with %71 and %65 was for ethanol and dichloromethane extract of Morad Byge propolis, respectively.
Conclusion: Considering the drug resistance of P. falciparum to conventional medicine and its dangers, and the emergence of development cheap and safe anti-malaria drugs to control and eliminate programs. Further investigation on Iranian propolis as safe and anti-malarial drug is recommended.