AU - Hooshmand, fariba AU - Alaie, hojatollah AU - Fesharaki, mehr afarin TI - EEG spectral power alternation & learning disability in rats exposure to lead through prenatal developing age PT - JOURNAL ARTICLE TA - Yafteh JN - Yafteh VO - 5 VI - 4 IP - 4 4099 - http://yafte.lums.ac.ir/article-1-994-en.html 4100 - http://yafte.lums.ac.ir/article-1-994-en.pdf SO - Yafteh 4 AB  - Introduction: Lead intoxication in children has been associated with neurodevelopment disabilities that may result in motor and cognitive impairment. The aim of the present study is to evaluate in long term effects of prenatal exposure to low-level Pb2+ on learning, memory and EEG. Materials & Methods: Rat pregnant were exposed to distilled water or 0.05, 0.1, 0.2 % of Pb-acetate in the drinking water during of pregnancy. Behavioral analysis was carried out in male offspring by using one way active avoidance. The numbers of electric shock was detected as an index of learning and memory of rats. At 60 days of age (active avoidance learning) and at 90 days of age (memory) behavioral assessment was measured. Then the rats were implanted with electrodes in sensorimotor regain. After a recovery period, EEG was also recorded. Findings: Lead acetate was no affected on learning but dose of 0.1% which was affected on memory of rats (No. of shocks 5.185 ± 0.98%) compared to the control (No. of shocks 1.667 ± 0.62%). This finding also showed that lead acetate (p CP - IRAN IN - LG - eng PB - Yafteh PG - 29 PT - Research YR - 2004