RT - Journal Article T1 - The effect of combined antioxidant supplement on serum lipids levels in female Patients with rheumatoid arthritis JF - Yafteh YR - 2013 JO - Yafteh VO - 14 IS - 5 UR - http://yafte.lums.ac.ir/article-1-1115-en.html SP - 93 EP - 104 K1 - Rheumatoid arthritis K1 - Antioxidant K1 - Supplement K1 - Serum lipids K1 - Atherosclerosis AB - Background: Rheumatoid arthritis (RA) is one of the autoimmune diseases with unknown etiology that its prevalence in females to males is 3 to 1. This disease has positive relationship with occurrence of atherosclerosis and cardiovascular diseases are taken into account for 50% of death in RA. Regarding the recent researches, antioxidant supplements may have important role in serum lipids reduction and atherosclerosis prevention, due to control oxidative stress. The aim of this study was to investigate the effect of combined antioxidant supplement on serum lipids in RA patients. Materials and Methods: A pre-post study was conducted in a 3 month period on 40 female RA patients which receiving daily one Selenplus capsule (selenium 50mcg, zinc 8mg, vitamin A 400mcg, vitaminC 125mg and vitaminE 40mg). Five ml venous blood was taken from all participants and serum levels of total cholesterol (TChol), triglyceride (TG), high density lipoprotein (HDL-c) were measured with enzymatic kits and low density lipoprotein (LDL-c) levels were calculated by Freidwald formula before and after the intervention. Data were analyzed by Shapiro-Wilk test and histogram with normal distribution for normal distribution, and for differences between pre-post data SPSS software version 13.5 was used. Results: Out of 40 patients, 39 completed the study. There were significant differences among TChol, TG, TG/HDL-c and LDL-c values (p LA eng UL http://yafte.lums.ac.ir/article-1-1115-en.html M3 ER -