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yafte 2006, 8(1): 3-11 |
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Tavakoli A, Delfan B, Esmaili dahaj M. Effects of enalapril on diabetic neuropathy in rats. yafte 2006; 8 (1) :3-11
URL: http://yafte.lums.ac.ir/article-1-1046-en.html
URL: http://yafte.lums.ac.ir/article-1-1046-en.html
Abstract: (11562 Views)
Background: Neuropathy is one of the important complications of diabetes.
Deficiency of the nerve conduction velocity (NCV) that occurs in both human
diabetic neuropathy and animal diabetes models is one of the indicators for diabetic
neuropathy. In the present study, we examined the effect of enalapril, angiotensinconverting
enzyme inhibitor on NCV, number of endoneurial capillaries and thickness
of the capillary basement membrane in motor sciatic nerves of diabetic and non
diabetic rats.
Materials and Methods: Fifty male rats, 300-450gr body weight, randomly
divided into five equal groups (control, sham, diabetic, prevention and treatment).
Diabetes was induced by subcutaneous injection of alloxan (140mg/kg). Body weight
and fast blood sugar were measured at the beginning of experiment and every endweek
during the course of experiment. Animals in the sham and prevention groups
received enalapril orally (5mg/kg/day) since the beginning of the experiment for five
weeks. Treatment group received enalapril (5mg/kg/day) for four weeks after five
weeks without treatment. NCV in motor sciatic nerve was measured at the end of the
period. Then, the number of capillaries and thickness of basement membranes in the
endoneurium of the motor sciatic nerve in all groups were examined.
Findings: NCV was reduced by 45% in diabetic rats compared with the control
group (p<0.001) after five weeks of diabetes. In prevention group, oral administration
of enalapril for five weeks could prevent reduction in NCV in diabetic rats by 62%
(p<0.05). Deficiency of the NCV is ameliorated by four weeks of enalapril treatment
by 66% (p<0.05), in addition, the number of endoneurial capillaries in sciatic nerve
increased by 67% (p<0.05). Administration of enalapril to non diabetic rats (sham
group) had no effect on NCV and number of endoneurial capillaries in motor sciatic
nerve.
Conclusion: Enalapril can have an effective role in prevention and treatment of
diabetic neuropathy.
Type of Study: Research |
Received: 2013/01/22 | Accepted: 2017/06/10 | Published: 2017/06/10
Received: 2013/01/22 | Accepted: 2017/06/10 | Published: 2017/06/10
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