Yafteh

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Background: Beta- lactamase enzymes produced by opportunistic and common pathogens, such as P. aeruginosa and inhibit the carbapenems and have potential of hydrolyzing a wide range of betalactam .They can easily be transferred to other bacteria. Materials and Methods: The strains of Pseudomonas aeruginosa were collected from clinical specimens. A standard test was performed to identify strains. Antibiotic resistant pattern was examined for different antibiotics and then the PCR test was used to detect the VEB1 gene. Results: The highest resistance rate was observed in amikacin and cefotaxime antibiotics with 65 and 62% , and the lowest resistance belonged to piperacillin and imipenem antibiotics (48% and 55%). 38 strains (60%) were carriers of VEB1 gene. Conclusion: The frequency of isolates producing VEB1beta-lactamase gene have been increased in hospital strains, this issue indicates the necessity for more attention on drug prescriplion by health centers. Also the molecular and rapid techniques are recommended to investigate the frequency of producing beta-lactamase strains in order to prevent the spread of these genes.

Keywords: Beta-lactamase, P. aeruginosa, Antibiotic resistance, Polymerase chain reaction (PCR).

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