Volume 16, Issue 4 (2-2015)                   yafte 2015, 16(4): 110-117 | Back to browse issues page

XML Persian Abstract Print

Download citation:
BibTeX | RIS | EndNote | Medlars | ProCite | Reference Manager | RefWorks
Send citation to:

Foroughi pour A, Meamar R. The evaluation of Serum testostrone level in reproductive age women with multiple sclerosis and its relation with disease severity. yafte. 2015; 16 (4) :110-117
URL: http://yafte.lums.ac.ir/article-1-1799-en.html
MSC. of Midwifery, Islamic Azad University, Najaf Abad Branch, Isfahan, Iran, azam-foroughipour@pmi.iaun.ac.ir
Abstract:   (3251 Views)
Background: Multiple Sclerosis (MS) is the most common demyelinating disease. An autoimmune basis has been confirmed for pathogenesis of MS, and studies have shown that sex hormones such as testosterone may play a role in the disease mechanism. The purpose of this study was to survey these changes in MS patients. Materials and Methods: 31 MS patients were included in this cross-sectional study and matched with 60 healthy coses as control group. The serum testosterone level of both groups were randomly determined in follicular and luteal phases. Then the testosterone hormone levels and their correlation with the disease were studied. Results: In this study, testestrone level in patients was 0.461 ± 0.3 ng/ml in the follicular phase compared to controls with mean level of 0.82 ± 0.4 ng/ml(pv=0.011) .Mean testestrone level in female patients was 0. 58 ± 0.7 ng /ml in the luteal phase compared to controls with mean level of 0.88± 0.3 ng/ml (pv = 0.03). Patients with MS had significantly lower testosterone, in the follicular and luteal phase, but no relation with the disease was observed. Conclusion: Testestrone has a positive relation with MS. Further studies to determine the cause of relation and effect of endocrine system on MS pathogenesis and treatment are suggested.
Full-Text [PDF 182 kb]   (1888 Downloads)    
Type of Study: Research |
Received: 2015/02/14 | Accepted: 2015/02/14 | Published: 2015/02/14

Add your comments about this article : Your username or Email:

Send email to the article author

© 2020 All Rights Reserved | Yafteh

Designed & Developed by : Yektaweb