Volume 20, Issue 1 (4-2018)                   yafte 2018, 20(1): 85-98 | Back to browse issues page

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Fallah rajabpour zare M, Rakhshan K, Aboutaleb N, Nikbakht F, Bakhshesh M, Azizi Y. Apigenin improves myocardial function and attenuates cardiotoxicity induced by doxorubicin in male rats. yafte. 2018; 20 (1) :85-98
URL: http://yafte.lums.ac.ir/article-1-2519-en.html
,Physiology research center and Department of physiology, faculty of medicine, Iran University of Medical Sciences, Tehran, Iran
Abstract:   (15469 Views)
Background: Doxorubicin has been used in the treatment of malignancies, including lymphoma, leukemia and breast cancer. Cardiotoxicity is the main adverse effect of doxorubicin. Apigenin, as a flavonoid, has antioxidant, anti-inflammatory and anti tumoral properties. The aim of this study is the assessment of the effect of apigenin on cardiotoxicity induced by doxorubicin.
Materials and Methods: 60 male wistar rats were divided into 6 groups. Cardiotoxicity was induced by 6 injections of doxorubicin (2 mg/kg, ip) over 12 days. The treatment groups received orally 25, 50 and 75 mg/kg/day apigenin for 12 days simultaneously with cardiotoxicity induction.
Results: The heart weight to body weight ratio showed no significant difference between different groups. In the apigenin group (25 mg/kg), EF and FS showed  a significant increase (P<0.05) and LVEDs, LDH and CK-MB showed a significant decrease, in comparison to the cardiotoxicity group.
Conclusion: Apigenin prevents LDH and CK-MB elevation and also EF and FS reduction and improves cardiac tissue changes and leads to a decrease in cardiac damage induced by doxorubicin. 
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Type of Study: Research | Subject: فیزیولوژی انسانی
Received: 2017/08/19 | Accepted: 2018/04/18 | Published: 2018/04/18

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