Volume 20, Issue 1 (4-2018)                   yafte 2018, 20(1): 123-132 | Back to browse issues page

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Toolabi K, Moazamipur A, Karvandian K, Dehpour A R. Effect of Low-Dose Naloxone on Pain Severity and Side Effects of Opioids on Patients Undergoing Laparoscopic Cholecystectomy. yafte. 2018; 20 (1) :123-132
URL: http://yafte.lums.ac.ir/article-1-2630-en.html
Abstract:   (2206 Views)
Background: Previous studies have assessed effect of naloxone on pain severity and side effects of opioids however, their results are inconsistent. Our study was design to determine effect of low-dose naloxone on pain, nausea, vomiting, pruritus and urine retention on patients undergoing laparoscopic cholecystectomy.
Materials & Methods: In this study 60 patients who need laparoscopic cholecystectomy participated and divided into two groups: naloxone (0.25 mg/kg/h naloxone plus 20 mg/kg/h morphine) and placebo (20 mg/kg/h morphine). Patients were evaluated 2, 4, 8 and 16 h after surgery and severity of pain and side effects including nausea, vomiting, pruritus and urine retention were recorded by a nurse.
Results: Prevalence of nausea, vomiting, pruritus and urine retention in naloxone group was significantly lower than placebo 2, 4, 8 and 16 h after surgery. There was no significant difference on pain severity between two groups.
Conclusion: Our results indicated that naloxone administration significantly decreased side effects of opioid including nausea, vomiting, pruritus and urine retention with no effect on pain severity.
Full-Text [PDF 246 kb]   (785 Downloads)    
Type of Study: Research | Subject: جراحی
Received: 2018/02/14 | Accepted: 2018/05/8 | Published: 2018/05/8

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