Amir Khosravi, Fatemeh Omidali, Bahram Rasoulian, Sirous Choobineh,
Volume 19, Issue 4 (10-2017)
Abstract
Background: Some scientific data have been reported the positive effects of natural antioxidants on modulating the Total Antioxidant Capacity and muscular damage indicators.
The aim of this research was to examine the effects of Short-Term Grapefruite juice Supplementation on Lipid Peroxidation and Total Antioxidant Capacity and some muscular damage indicators in young men following a session of intensive an resistanceactivity.
Materials and Methods: In a randomized double-blind study twenty young men students were randomly divided into two equal groups of experimental, and control. After supplementation period, subjects performed a session of intensive resistance activity at 85% of one repetition maximum. Changes in the Total Antioxidant Capacity and malondialdehyde and muscular damage indicators (Lactate dehydrogenase and Creatine Kinase) were determined in three phases.
Results: The results showed that changes in the Total Antioxidant Capacity and malondialdehyde after exercise not significantly in the supplementation group, but significantly in the control group. Also, changes in plasma Lactate dehydrogenase and Creatine Kinase after activity were significantly in the control and supplementation groups.
Conclusion: It seems that Short-Term Grapefruit juice supplementation will be useful for improving levels of plasma Total Antioxidant Capacity and thereby inhibiting exercise-induced lipid peroxidation and modification in plasma increased Lactate dehydrogenase and Creatine Kinase after intensive resistance training.
Hamid Amini, Mohammad Ali Azarbayjan, Kamal Azizbeigi,
Volume 19, Issue 5 (2-2018)
Abstract
Background: The purpose of this study was to investigate the effect of ginger supplementation on the gene expression of catalase (CAT), glutathione peroxidase (GPX), superoxide dismutase (SOD) enzymes and malondialdehyde (MDA) levels.
Materials and Methods: In a semi-experimental trial, 20 students with 20-25 years old from Shahed were selected and randomly divided into experimental (10) and control (10) groups.
The experimental group received one gram of ginger capsule at the doses of 250 mg, four times a day, for eghit weeks. Control subjects, also received placebo (maltodextrin) in the same manner. Blood samples were taken 72 hours before the start and 72 hours after the completion of the research protocol. The statistical methods of Kolmogorov-Smirnov, t dependent and independent, as well as SPSS (version 22) and Excel were used (P <0.05).
Results: There was no difference between the groups in the gene expression of the antioxidant enzymes and MDA levels (p = 0.144 for SOD, p = 0.234 for cat, p = 0.1 for GPX, and p = 0.201 for MDA). In the experimental group, ginger supplement lead to significant reduction in MDA levels (p = 0.01).
Conclusion: According to the results of this study, it can be said that eghit weeks of supplementation of ginger may reduce the lipid peroxidation without affecting gene expression of antioxidant enzymes.
Rastegar Hoseini, Zahra Hoseini,
Volume 20, Issue 4 (1-2019)
Abstract
Background: Coronary artery disease (CAD) is a leading cause of mortality and disability in Iran and obesity is considered as one of the main causes. The purpose of this study was to compare the effect of aerobic training and turmeric supplementation on cardiovascular risk factors in overweight women.
Materials and Methods: In this study, 40 healthy non-athlete women with an average age of 23.23±2.98 years were randomly divided into four groups of training- curcuma longa supplement (n=10), training-placebo (n=10), turmeric supplement (n=10) and placebo (n=10). Aerobic training program consists of three sessions of running per week with 45-55 percent of target heart rate for 8 weeks. Supplement group consumed 1 gr/day turmeric. Before and after the intervention, TC, TG, HDL-C and LDL-C were measured.
Results: All three groups (aerobic training, turmeric supplementation, and aerobic training + turmeric supplementation group) showed a significant reduction in weight, BMI, TC, TG and LDL and an increase in HDL (P<0.05). Also, the results show that aerobic training + turmeric supplementation group compared with aerobic training, turmeric supplementation significantly caused reduction in TC, TG and LDL and an increase in HDL (P<0.05).
Conclusion: The results showed that 8 weeks of aerobic training with turmeric supplementation is more effective in the overweight women’s cardiovascular risk factors and body composition than either aerobic training or turmeric supplementation alone.
Somayeh Saboori, Ebrahim Fallahi, Amir Abbas Nezhad, Sajjad Roosta, Esmaeil Yousefi Rad ,
Volume 21, Issue 2 (9-2019)
Abstract
Background: Studies have shown that Sirtuins have critical roles in the regulation of inflammation and oxidative stress, while hTERT has a protective effect via increasing the length of telomers in cardiovascular disease. The aim of this study was to assess the effects of omega 3 and vitamin E supplementation on the gene expressions of SIRT1 and hTERT and serum hsCRP level in CAD patients.
Materials and Methods: Participants in this Randomized Clinical Trial consisted of 60 non-smoking male CAD patients, with age ranges 45- 65 years, who were categorized into three groups, receiving: 4g/day of omega 3 and vitamin E placebo (OP); omega 3 (4g/day) and vitamin E 400IU/day (OE); and omega 3 and vitamin E placebos (PP) for two months.
Results: Gene expression of SIRT1 increased significantly in the OE group (P = 0.039), but gene expression of hTERT was not significantly different between the study groups. Supplementation with omega 3 and also co-administration of these fatty acids with vitamin E significantly decreased hsCRP level in OP and OE groups (P=0.008 and P= 0.050, respectively).
Conclusion: Supplementation with omega 3 and vitamin E seems to include beneficial effects on CAD patients, possibly via increasing gene expression of SIRT1, and also by lowering inflammation through decreasing serum level of hsCRP in these patients.
Farah Nameni, Peyman Akraminia,
Volume 21, Issue 4 (1-2020)
Abstract
Background: Continuing training programs can improve sport performance. However, these exercises can cause pressure on the hormonal and metabolic systems. Resveratrol might be effective on the improvement of the alterations induced by continuing training. The present study investigated the simultaneous effect of resveratrol consumption and continuous exercise on BDNF and GGT.
Materials and Methods: In this experimental study, 24 rats were randomly divided into the 2 groups of continuous exercises, and resveratrol supplement + continuous exercises. Resveratrol solution was administered to the resveratrol + ontinuous exercises group for 8 weeks, each day 8 mg per 100 g of the body weight. The treadmill continuous training program was carried out for 8 weeks. At the end of the course, blood was obtained for measuring the indices of BDNF and GGT. These indices were analysed by SPSS software, version 22.
Results: The results indicated the higher mean of GGT and the lower mean of BDNF in the continuous training + resveratrol compared to the continuous exercises group. The use of resveratrol caused a significant increase in BDNF (P = 0.007) and GGT (P = 0.06) in the continuous training+ resveratrol group.
Conclusion: The results of the present study showed that continuous exercise + resveratrol consumption were effective on controlling and improving the indices changes in BDNF and GGT. The simultaneous effect of supplementation and exercise increased the metabolic, neurological and protective opposite effects
Mohammad Ariana, Hamed Beiranvand,
Volume 22, Issue 2 (8-2020)
Abstract
Background: Microbial resistance is one of the major problems leading to the spread of illness and death in the worldwide. Virginiamycin is one of those antibiotics that have been approved for use in the poultry, but in recent years, attention has been paid to replacing these compounds with natural additives such as powder and extracts of medicinal herbs, in livestock nutrition and poultry.
Materials and Methods: In this experiment, 125 hens of white Leghorn chicken (Hay-line) were used at age 64 weeks. Hens were divided into five groups with five replicate cages containing five hens each for each group. In this study, the effects of garlic and sage powder in the diet of laying hens, alone or in combination, with an emphasis on antimicrobial properties, were evaluated in comparison with antibiotic Virginiamycin, and the effect of these compounds on some biochemical parameters, blood and histomorphology of the intestine were investigated. The experiment was conducted in a completely randomized design with 5 treatments and 5 replications with 5 observations in each replication
Results: The results showed that different experimental treatments, including garlic powder, sage or their mixture, also Virginiamycin resulted in a significant increase in villi height (P<0.05) and villi height to crypt depth ratio (P<0.05), while the effect of sage powder and Virginiamycin on crypt depth was not significant. Furthermore, the addition of different experimental treatments significantly altered the intestinal microflora, and except for Lactobacillus that decreased significantly, the reduction in the number of germs including E. coli, Salmonella and total bacteria was significant.
Conclusion: It seems that a large part of the antimicrobial properties of these compounds in this study can be due to the ability of herbs active compounds or essential oils that are capable of eliminating bacteria due to the instability of membranes, including mitochondria membrane and imbalance in the membrane integrity of bacteria, and possibly reduce the damage to intestinal erythrocytes, also reduced the cellular requirements for the proliferation of new cells in the intestine. So that, the use of experimental treatments led to higher villi height and less crypt depth.
Mansour Karajibani, Farkhondeh Mahmodee Meymand , Farzaneh Montazerifar, Ali Reza Dashipour,
Volume 22, Issue 4 (1-2021)
Abstract
Background: Due to the increasing prevalence of preeclampsia and eclampsia syndrome and it's multifactorial nature and the relationship between zinc and this syndrome, this study was designed to compare serum zinc level in pregnant women with preeclampsia or eclampsia and healthy in Ali Ibn Abitaleb Hospital in Zahedan.
Materials and Methods: In a case-control study, 50 pregnant women with pre-eclampsia or eclampsia and 50 healthy pregnant women were selected based on inclusion and exclusion criteria by
convenient sampling method, 2019. After recording demographic and clinical characteristics in each questionnaire in two groups, 3 ml of blood was taken from each person. Serum zinc was determined by atomic absorption, spectrophotometry. Quantitative and qualitative data were described and analyzed as independent t-test by SPSS software: 16
Results: The results showed that the mean serum zinc level was not significantly different between the case and control groups, but the frequency of serum zinc deficiency in the case group was higher than the control (P< 0.01). In pregnant women with a gestational age of 34 weeks and more, the serum zinc in the case group was lower than control (P=0.04). In addition, hypertension in healthy pregnant women is associated with serum zinc levels. Complications such as pre-hypertension, proteinuria, and abortion were more common in case group (P< 0.05).
Conclusion: Findings indicate that although the mean serum zinc in the two groups was not significantly different, but the frequency of serum zinc deficiency was higher in the case group. Nevertheless, screening for serum zinc deficiency and its treatment along with other diagnostic and clinical methods can be effective in ensuring health and preventing preeclampsia or eclampsia in pregnancy.
Mozafar Mohammadi Nejad, Abbas Najafpour, Behrouz Etesami, Mehrdad Valipour, Gholam Reza Ahmadpour, Keramat Niazi, Shabnam Dalvand,
Volume 22, Issue 4 (1-2021)
Abstract
Background: The most common iodine deficiency disorders (IDD) are; Hypothyroidism, simple goiter, psychomotor problems, hearing-neurological disorders and cretinism. This study was carried out to evaluation of urinary iodine in 8-10 years old students in lorestan province in 2019.
Materials and Methods: In this analytical descriptive study, 236 students of both sexes aged 8-10 years from urban and rural areas were selected randomly by cluster sampling and urinary iodine measured based on acid digestion. The results were analyzed using Statistical Package for the Social Sciences (SPSS; version 20).
Results: In this cross-sectional descriptive study the urinary iodine excretion median was 6 mg/dl and in 21.2% was more than 10 mg/dl and in 78.8% was less than 10 mg/dl. urinary iodine excretion median difference was significant for urban and rural students (p = 0.021).There was no significant relationship between gender and age variables with the median urinary iodine excretion in students.
Conclusion: The results of this study showed that urinary iodine excretion in Lorestan school students is not at the desired level of the World Health Organization; Therefore, it is necessary that the measures taken by the provincial committee for the control of iodine deficiency disorders be evaluated.
Mohammad Mahdi Madani, Bahram Abedi,
Volume 23, Issue 0 (11-2021)
Abstract
Background: Obesity is associated with a chronic inflammation that plays a major role in the development of metabolic disorders or insulin resistance. The aim of this study was to evaluate the effect of 8 weeks of aerobic exercise with curcumin supplementation on proinflammatory factors in obese men.
Materials and Methods: 20 obese men in the age range of 30 to 40 years were purposefully selected and randomly divided into two equals experimental (supplementary) and control (placebo) groups. The experimental group participated in a moderate-intensity aerobic exercise program (60-70% of maximum heart rate) for three weeks, three sessions per week, and each session lasted about 60 minutes. At the same time, they took 500 mg of curcumin daily in capsule and placebo groups. The control group also took a placebo (rice flour). Before and after the supplementation training intervention, blood samples were taken from all subjects during 10 hours of fasting. Inflammatory markers including TNFα, IL-1β and BDNF were assessed by ELISA. Data were analyzed using analysis of covariance (p <0/05).
Results: The results showed that eight weeks of aerobic exercise with curcumin supplementation, in addition to improving body composition, caused a significant decrease in TNFα (p = 0/0001) and IL-1β (p = 0/0001) and also a significant increase in BDNF values (p = 0/0001) in obese men.
Conclusion: The findings of this study show that curcumin supplementation along with moderate-intensity aerobic exercise can improve inflammatory conditions in obese men.
Keywords: Obesity, Inflammation, Curcumin, Aerobic exercise.
