Showing 12 results for Cheraghi
Eskandar Hajiani, Seyed Jalal Hashemi, Mostafa Cheraghi,
Volume 8, Issue 1 (6-2006)
Abstract
Background: Hepatocellular carcinoma (HCC) is common all over the world as
well as Iran. The incidence of HCC is higher in hepatitis B carriers and it is highly
recommended to periodically screen these patients by serum alpha-fetoprotein (AFP)
and liver ultrasound (US) every 6 months. We explore the diagnostic accuracy and the
performance of (AFP) in cases of hepatitis B carriers as a screening tool by using
serum total AFP concentration of 20 ng/ml.
Materials and Methods: The study included 2452 HBsAg carriers with no
evidence of hepatocellular carcinoma or cirrhosis were followed up in a 6-year
prospective surveillance program with testing by ultrasound and alphafetoprotein
every 6 months referred to the Ahwaz JundiShapour university hospitals and hepatitis
clinic (1999-2004). Men and nonpregnant women with an elevated AFP level were
evaluated for the presence of HCC by ultrasound (US) examination. Hepatitis B
surface antigen (HBsAg), anti-HBc antibody and alpha-fetoprotein (AFP) were
determined in all cases by enzyme-linked immunosorbent assay (ELISA).
Findings: One or more AFP elevations (higher than 20 ng/ml) were found in 32
cases, but 13 (45%) hepatocellular carcinomas were detected in these patients during
follow up (9 men and 4 women). Of the 32 HBsAg carriers with AFP serum levels of
more than 20 ng/ml, HCC was not detected in 19 cases (65%). The positive predictive
value for AFP to detect HCC was only 31% for our AFP cut-off value, and the
sensitivity and specificity was approximately 56 and 88%, respectively.The positive
predictive value for ultrasound examinations to detect HCC was 64%, while the
sensitivity and specificity was 90 and 92%, respectively.
Conclusion: We conclude that AFP alone is not a useful marker for HCC screening
because of its poor predictive value and low sensitivity, particularly in patients with
underlying viral hepatitis B without cirrhosis and is not recommended except when
ultrasonography is either not available or of poor quality. Ultrasonography seems
more efficient and accurate as a screening tool.
Eskandar Hajiani , Seyed Jalal Hashemi , Abdolrahim Masjedi-Zade , Mostafa Cheraghi ,
Volume 8, Issue 3 (11-2006)
Abstract
Background: Hepatitis C virus infection (HCV) is a main health problem in our country. It is thought that the transmission of hepatitis C virus (HCV) through the endoscopic procedures is a rare event. The aim of this study was to evaluate the risk of conventional disinfection in the transmission of HCV.
Materials and methods: A prospective study, comprising 456 consecutive upper gastrointestinal endoscopies was carried out in our endoscopy centers by using conventional disinfection (exposure of the endoscope to 2% glutaraldehyde for 4 minutes),Without altering the routine procedures. Anti-HCV antibodies were tested for all patients and a questionnaire was fulfilled by the patients to obtain information regarding the risk factors for HCV infection. Six months and one year later anti-HCV antibodies were repeated and positive results were confirmed by the PCR method.Five hundred healthy blood donors were used for the control group.
Results: Five patients (1.09%) were anti-HCV-antibody positive. Anti-HCV-antibody-positive patients confirmed in three patients by PCR method . Anti-HCV antibodies were found in 6 healthy blood donors (1.2%) of controls.Transfusion, non-intravenous (i.v.) drug abuse, dental procedures, were found to be independent risk factors of HCV-positive the patients and controls groupsNo significant differences were observed between the patients and controls groups regarding the frequency of anti-HCV antibodies (P = 0.74).
Conclusion: HCV does not seem to transmit through the endoscopic procedures. Conventional disinfection of the endoscope and accessories is sufficient for prevention of HCV transmission.
Karim Mola , Mostafa Cheraghi , Soleiman Jaferian , Ali Ahmad Mosadegh ,
Volume 8, Issue 4 (1-2007)
Abstract
Background: Osteoporosis is one of the most common problems in the women, especially after menopause and at the old age. Bone densitometry of vertebrae of lumbar region and femoral neck is a non invasive and precise method for evaluation of bone mass density (BMD) and determination of fracture risk.
Materials and Method: from different districts of Ahvaz city, more than 300 healthy men and woman were selected. They were referred to the center of bone densitometry after ruling out underlying diseases. BMD evaluation was done with LUNAR apparatus.
Results: There was a meaningful difference between BMD of men and women. There was also a meaningful difference among women groups regarding LUNAR standard. But this was not the case in the men.
Conclusion: It was concluded that there is a meaningful difference between the mean of BMD in the femoral neck and lumbar region. In addition there was a difference between these two regions in women (not men) and lunar standard.
Mohammad Mehdi Aslani , Marjan Hahsemipour , Vajihe Sadat Nikbin , Fereshte Shahcheraghi , Akram Eidi , Zeinab Sharafi ,
Volume 11, Issue 2 (yafteh 2009)
Abstract
Background: Pseudomonas aeruginosa has emerged as one of the most important nasocomial pathogen resulting in morbidity and mortality rates.
The aim of this research was to PCR identification of P. aeruginosa isolated from tracheal samples based on the amplification of I lipoprotein (oprI) for detection of genus and L lipoprotein (oprL) for detection of species and Exotoxin A (toxA) gene.
Materials and Methods: A total of 120 P. aeruginosa clinical isolates were collected from patients with tracheal infections. Chromosomal DNA of the isolates was extracted and used for PCR of oprI, oprL and Exotoxin A (toxA).
Results: From 120 P. aeruginosa 100% were positive for oprI and oprL genes based on PCR assay and from these samples 83% were positive for ExotoxinA (toxA).
Conclusion: Using PCR method with genome and specific primers can be more accurate and sensitive than biochemical tests to identify P.aeruginosa strains. It is also replaceble method for biochemical methods.
According to the results obtained by PCR test toxA gene is not as sensitive as oprI and oprL to recognize P. aeruginosa. So using PCR of all these three genes are necessary to detecte this bacterium.
Korosh Cheraghi Pour , Ali Sheikhian , Amir Hosein Maghsoud , Ziya Hejazi , Mohammad Rostami Nejad , Kobra Moradi Pour,
Volume 11, Issue 4 (yafte 2010)
Abstract
Background: Toxoplasmosis is one of the a parasitic infectious caused by the protozoan Toxoplasma gondii. Congenital toxoplasmosis can cause abortion or fetus damage in pregnant women. The purpose of this study was to determine the seroprevalence of toxoplasmosis (IgG & IgM) among the pregnant women referred to Aleshtar rural and urban health centers in 2008.
Materials and Methods: Total 331 blood samples were collected from 204 urban and 127 rural pregnant wemon referred to rural and urban health centers of Aleshtar. After recording their information in the questionnaire and preparation of sample, all samples were evaluated with IgG- and IgM-ELISA to detect anti-Toxoplasma gondii antibodies. Data were analysed by descriptive statistics and chi-square test.
Results: In this study seroprevalence of toxoplasmosis in urban and rural pregnant women were 36/2% and 44%, respectively. And 11. 2% of the urban and 9. 4% of the rural women suffered from acute Toxoplasma infection while 25% and 34. 6% of the urban and the rural cases had chronic infection, respectively. The results of analysis showed that there were significant relationships between seropositivity (IgG and IgM) and education level, age, contact with raw meat, contact with cat, kind of food, washing vegetables, consumption of vegetables and milk in both urban and rural pregnant women (p<0. 05). There was no significant difference between seropositivity and other variables.
Conclusion: The results of this study showed that the high level of education and preferment health awareness can reduce the risk of toxoplasmosis. Nevertheless, %60. 8 of the pregnant women in this study didn’t have previous history of toxoplasma infection and are exposed to primary infectin and acute disease. Therefore, preventive measures and controlled programs are necessary.
Farshid Shamsaei , Fatemeh Elhani , Fatemeh Cheraghi , Ali Ghale Iha ,
Volume 11, Issue 4 (yafte 2010)
Abstract
For all individuals, mental, physical and social health is vital strands of life that are closely interwoven and deeply interdependent. And mental health is crucial to the overall well-being of individuals, societies and countries. Objectives: The aim of this study is to identify the mental health needs of Hamedanian people. Materials and Methods: This was a descriptive cross-sectional study. The participants consist of 1300 persons who were selected by stratified sampling. A 30- item questionnaire was used to gather data from the samples. It consisted of three parts: A-demographic factors, B-questions related to mental health service delivery and C- questions related to mental health needs. Results: Results showed that the Hamedan city people believed that mental health services are inadequate, they did not access services near their home (76%) and mass media educational programs about services was poor(34%). The expressed needs of people were: mental health education (72%), established mental health centers in schools (52. 8%) and factories (50. 7%) and expanding the comprehensive mental health centers in the city(57. 8%). Expanding the assurance services (85. 6%), modifying wrong beliefs and ideas about mental illness (42. 6%), and improving the mental health in society. Conclusion: Community based mental health services should to provide comprehensive and local cares and treatments. Services should be comprehensive in that they provide a range of facilities to meet the mental health needs of the population at large as well as of special groups, such as children, adolescents, women and elderly people.
Masoume Sadeghi, Pezhman Aghdak , Ramin Heidari, Sedighe Dehghan Naseiri , Rezvan Ghaheri, Mostafa Cheraghi , Nazal Sarrafzadegan ,
Volume 13, Issue 4 (3-2012)
Abstract
Background : The aim of the study was to evaluate the relationship between main CVD risk factors and healthy life style of housewives and working women.
Materials and Methods: The current study was a part of the Isfahan Healthy Heart Program (IHHP). Data sampling was stratified multistage sampling in the women over 20 years old. Demographic information, nutritional status as Global Dietary Index (GDI), physical activity and smoking status were recorded. Blood pressure, anthropometric indicies, total cholesterol, LDL-c and HDL-c, TG, FBS were detected. Collected data were processed by T -test, chi square and logistic regression.
Results: 5591 (92%) out of 6102, were housewives and the rest were working women.The nutritional status in working women was worse than the housewives. In contrast, the physical activity was better in working women. There were no significant differences between two groups regarding smoking. After adjusting for age, BMI, Lipid profile and blood pressure were the same in the both groups. Dyslipidemia, diabetes and obesity were not significantly different between two groups.
Conclusion: Regarding the results, a more comprehensive interventional program for healthy lifestyle and risk factors should be carried out.
Nazal Sarrafzadegan , Katayon Rabiei , Masoume Sadeghi , Mozhgan Gharipour, Mohammad Hosein Hosieni , Behzad Zolfaghari , Mostafa Cheraghi , Abas Feizbakhsh, Ali Mostofi , Sonia Zarfeshani ,
Volume 14, Issue 1 (6-2012)
Abstract
Background : Healthy Life for Cardiovascular Patients(HLCP), one of the ten projects included in Isfahan Healthy Heart Program, was designed and performed based on high-risk and secondary prevention strategies and aimed to reduce cardiac recurrences, along with the risk factors, morbidity and mortality among cardiovascular patients. In this study we investigate the trend of changes of frequency of coronary patients’ medicine intake, aswell as the results of process evaluation.
Materials and Methods: Five main strategies were designed to meet the project's goals. These interventions were designed based on education, legislation, and attracting inter-division and public cooperation. Process evaluation was performed in order to determine the project's successfulness. Prior to the project, the morbidity and medicine intake among the patients were also studied. These indices were again measured during the interventions and also after the project were completed.
Results: Amongst all the interventions, educating the patients during the hospitalization period, at the time of release and also post-release educations were successful. Another success of the project in merging secondary prevention programs in the society was to attract public coordination and to establish a Non-Governmental Organization. The results also show an increase in the amount of aspirin, beta blockers, Angiotensin Converting Enzyme (ACE) Inhibitors, and statins taken by cardiovascular patients during the project.
Conclusion: The results suggest that secondary prevention and cardiovascular patient care promotion interventions can be performed using available facilities.
Mehrnoosh Sedighi, Mostafa Cheraghi, Pejman Hashemzadeh,
Volume 23, Issue 0 (11-2021)
Abstract
Background &Objective: Despite the fact that public awareness about diabetes control and cardiovascular diseases has increased, but still the main cause of morbidity and mortality in the community. For the treatment and control of diabetes and heart disease can be pharmacological and nonpharmacological methods used. The purpose of this review study is to introduce several risk factors in diabetic patients that increase the chances of cardiovascular involvement.
Materials and Methods: In this review study, Pubmed, ISI and Scopus databases were used to search for articles during the years 1979 to 2020, and the keywords of blood pressure, oxidative stress, obesity, dyslipidemia, endothelial function and inflammatory factors were used.
Results: The worldwide prevalence of diabetes and the occurrence of serious and dangerous complications on the organs of the body, has made this disease a major health problem in all communities and is the main cause of cardiovascular disease. Our study showed that cardiovascular disease is the most common cause of death in diabetic patients. Factors associated with diabetes and cardiovascular disease include high blood pressure, oxidative stress, obesity, dyslipidemia, endothelial function, and inflammatory factors.
Conclusion: Diabetes is a major cause of cardiovascular disease. Cardiovascular disease is also the most common cause of death in diabetics.
Eftekhar Mohammadi, Mohammad Fathi, Farzaneh Chehel Cheraghi, Afshin Nazari,
Volume 23, Issue 0 (11-2021)
Abstract
Abstract: (The effect of 6 weeks of endurance training and Empagliflozin consumption on heart weight and electrical changes of the heart in male Wistar rat's diabetic with STZ
)
Introduction: One risk factor for heart disease is type 2 diabetes, which plays a major role in mortality from cardiovascular disease. The aim of this study was to evaluate the effect of 6 weeks of endurance training and Empagliflozin consumption on some indicators of electrical heart activity in male diabetic rats.
Methods: 40 male Wistar rats (250
±20 g) with an age range of 8-10 weeks were randomly divided into five groups: Diabetes Exercise (D + EX), Diabetes+Exercise+Empagliflozin (D+EX+EMP), Diabetes + Empagliflozin (D + EMP), control diabetes (DC) and control group (CONTROL) were divided and were kept in laboratory conditions. The (D + EX + EMP) and (D + EMP) groups also received empagliflozin by gavage for the same period and daily. 48 hours after the completion of the protocol, rats were anesthetized and an electrocardiogram (ECG) was recorded and then cardiac tissue was isolated and dissected. One-way ANOVA and Kruskal-Wallis statistical tests and Tukey, Games-Howell, Tamhane's T2, Dunn and Dunnett'sT3 post hoc tests were used for statistical analysis.
Results: Mean weight and blood glucose at the beginning of the study were not significantly different in the 5 groups, but after the end of the protocol, significant changes in weight, heart weight, serum glucose, QRS time, QT interval, QTc and ST height were observed in rats.
Conclusion: The results of the present study showed that endurance exercise and the use of Empagliflozin can have a positive effect on the electrical conduction current of the heart of diabetic rats through reconstruction.
Arash Karimi, Mostafa Cheraghi, Mehrnoosh Sedighi, Pejman Hashemzadeh,
Volume 23, Issue 2 (5-2021)
Abstract
Background: Nowadays opium addiction is most important problem in most countries. There are some false beliefs about role of opium in prevention and control of heart disease in society, thus suggestion about opium usage is common in this regard. This review is written based on studies that were performed about relation between opium addiction and heart disease.
Materials and Methods: In this review study, relevant articles indexed in Information Sciences Institute, PubMed, Scientific Information Database, IranMedex, SID, PubMed and Scopus were used to search between 1980 and 2017, with further emphasis on those indexed from 2008 to 2019. We used these keywords to search: opium addiction, lipid peroxidation, blood sugar, blood fat, atherosclerosis, infarct size, arrhythmia and heart disease done in people opium addiction.
Results: Data showed the relation between opium addiction and lipid peroxidation, blood sugar, infarct size, arrhythmia and Malondialdehyde index. Different effects have been observed in different studies. This difference may be due to the effect of anesthesia, the dose of the drug, the site of action in the brain, respiratory changes, and the characteristics of the receptors.
Conclusion: Opium addiction associated with different effects on blood sugar, blood fat, blood pressure, atherosclerosis, infarct size, arrhythmia and heart disease.
Mostafa Cheraghi, Pejman Hashemzadeh, Mehrnoosh Sedighi, Arash Karimi,
Volume 27, Issue 1 (12-2025)
Abstract
Background: The present study was designed to evaluate the effect of Valepotriate (from Valeriana officinalis) on pain and inflammation in rats and to determine its possible analgesic and inflammatory mechanisms.
Materials and Methods: The present study was conducted with the objective of investigating the anti-inflammatory effect. To this end, 40 male rats were randomly divided into five groups. In the pain test, 56 male rats were randomly divided into seven groups (n=8 each).
Inflammation test: 1- Normal saline group, 2- Xylene group, 3- Dexamethasone group, 4 and 5- Groups that received the active ingredient Valepotriate at doses of 0.2 and 0.1 mg/kg as a single dose for each animal.
Pain test: 1- Saline group, 2- Formalin, 3- Morphine + Formalin group, 4-5- Valepotriate group (0.2 and 0.1 mg/kg) + Formalin, 6- Naloxone + Extract group (0.2 mg/kg) + Formalin, 7- Naloxone+ Morphine + Formalin group
Results: The results showed a significant decrease in pain response time at 0.2 doses of Valepotriate in acute and chronic pain phases compared to Formalin (P<0.001). Valepotriate active ingredient also exerted its inhibitory effect on xylene-induced inflammation, with the best inhibition percentage observed for 0.2 mg/kg dose and dexamethasone with extract at 0.2 mg/kg (P<0.01).
Conclusion: According to the results, Valepotriate has a relatively strong analgesic effect. It is likely that the mechanism of analgesic action of the extract is at least relatively similar to that of morphine based on opioid receptors. In the inflammation test, the extract was able to inhibit inflammation in a way similar to dexamethasone.
