Showing 7 results for Eslami
Koros Div-Salaar , Ramin Saravani , Manzomeh Shamsi-E-Meimandi , Morteza Taei , Azar Sheikholeslami,
Volume 9, Issue 4 (Yafteh 2008)
Abstract
Div-salaar K1, Saravani R2, Shamsi-e-meimandi M3, Taei M4, Sheikholeslami A5 1. MSc. Staff member of Neurology Sciences Research Center, Kerman University of Medical Sciences 2. Instructor, Department of Biochemistry, Faculty of Medicine, Zahedan University of Medical Sciences 3. Instructor, Department of Physiology and Pharmacology, Faculty of Medicine, Neurology Sciences Research Center, Karman University of Medical Sciences 4. Researcher, Neurology Sciences Research Center, Karman University of Medical Sciences 5. B.Sc in Environmental Hygiene, Kerman University of Medical Sciences Abstract Background: The prevalence rate of opioids consumption is high in Iran. The latest research approach related to substance abuse considers the role of plasma proteins in novel treatments of addiction. Since long-term consumption of opioids has some effects on liver function and plasma transfer systems, the present study was designed to determine the electrophoretic profile of plasma proteins in opiates-addict subjects. Materials and methods: In this cross-control study, the sample groups consisted of 42 opium consumers and 35 heroine dependents as case group and 35 non-addict volunteers as control group. The control group was matched with addicts for age and sex. Opioid consumption was confirmed by laboratory diagnostic tests on urine samples such as immunochromatography (RSA), rapidosis and complementary tests including liquid-solid column chromatography and thin layer chromatography (TLC). After blood collection and serum preparation, serum electrophoresis was performed. Data were presented as mean±SEM and analyzed by SPSS ver.11.5. The comparison of groups was done by using parametric tests and p<0.01 was considered as statistically significant. Results: There was no significant difference in the amounts of albumin, alpha-1-globulin, alpha-2-globulin and beta-globulin between groups. Gamma-globulin concentration was not significantly different between opium addicts (17.38 ± 3.61gr/L) and heroin addicts (17.48 ± 4.4gr/L), but it was significantly high (p<0.01) in both heroin and opium groups compared to the control group (13.3±1.8gr/L). Conclusion: Morphine bonding to serum albumin and other impurities in narcotic drugs may lead to the production of antigen complexes, stimulation of immune system and consequently increase in gammaglobulins concentration. Also, opioids binding to opiate receptors, directly or indirectly, can affect immune system through stimulating hypophysis-hypothalamus pathway. Although continuous consumption of opioids affects both cellular immune and hormonal systems, significant increase of gammaglobulin band can be related to the high risk behaviors associated with opioids consumption and the higher probability of infectious diseases in addicts due to poor health status.
Touran Shahraki, Mansour Shahraki, Gholamreza Soleimani, Omid Eslami,
Volume 20, Issue 3 (10-2018)
Abstract
Background: Recurrent abdominal pain is one of the common complaints in childhood. The aim of this study was to determine the frequency of Helicobacter pylori and giardiasis in children with recurrent abdominal pain and to investigate some risk factors in both infections.
Materials and Methods: In a case-control study 50 symptomatic children and 50 healthy children at Pediatric Center in Zahedan, Iran from 2014-2015 were enrolled. All cases had gastric complaints and undergone endoscopy. Children in both groups were examined for detecting H.pylori stool antigen and presence of giardia infection by direct examination of stools. Risk factors were recorded in both groups by a questionnaire.
Results: 100 children with the age of 6.2 ± 3.7 (58 female) were included. H.pylori stool antigen was positive in 32(64%) cases and 10 (20%) in control group which showed significant differences. Also, endoscopic antral gastritis with colonization of helicobacter pylori were found in 46 cases (92%). Giardiasis was detected in 12% patients and 6% controls, respectively. Co-infection with H. pylori and giardiasis was present in 8% of patients compared to 2% of controls. There was no difference between groups regarding some risk factors except more using common bed in cases.
Conclusion: Co-infection with H.pylori and giardiasis was more frequent in children with recurrent abdominal pain compare to control group. More attention to hygienic conditions in the community is recommended.
Reza Hajihossein, Azam Moslemi, Zahra Eslamirad,
Volume 22, Issue 1 (4-2020)
Abstract
Background: Some eukaryotic microorganisms, including flagellated protozoan called Trichomonas tenax, are effective in causing periodontal diseases. The purpose of this study is to review Iranian articles on the prevalence of Trichomonas tenax in order to provide a comprehensive description of the prevalence of this parasite in the country.
Methods: To investigate the research articles on the prevalence of Trichomonas tenax on the Iranian population, a systematic search was conducted in Persian and English databases. The search process led to the inclusion of 9 articles into this systematic review, all of which entered meta-analysis.
Results: In the reviewed articles, a total of 1,651 people had been examined for Trichomonas tenax infection. Based on the random effects model, the prevalence of this parasite in Iran was 0.07 with a 95% confidence interval (0.02-0.13) (P< 0.001).
Conclusion: The findings of the experimental study showed that the maximum Trichomonas tenax prevalence in Iran was 36.6%. On the other hand, the prevalence of this parasite is higher in patients with periodontitis than in healthy individuals. Hence, the parasite can be a serious concern for the health of the oral cavity. Therefore, it is necessary to estimate the prevalence of this infection using standard methods. Moreover, the factors associated with the prevalence of this parasite should be examined.
Mahmoud Darvishi, Vahid Valipour Dehnou, Rasoul Eslami,
Volume 22, Issue 2 (8-2020)
Abstract
Background: Aerobic exercise increases serum levels of BDNF, Irisin, and Cathepsin B, but the effects of it in the manipulated environment have not been investigated. Therefore, the aim of the present study was to investigate the effects of aerobic exercise in manipulated environment on serum levels of BDNF, Irisin and Cathepsin B in healthy active adolescents in Khorramabad.
Materials and Methods: In this quasi-experimental study, 10 healthy active male adolescents (age: 16.60±0.52 years) voluntarily participated. The subjects underwent a one-hour running with intensity between 12-13 in Borg scale one session in an ordinary environment and one session in an enriched environment interspersed with one week in a randomized cross-over design. Five minutes before and after the training, a blood sample was taken from the subjects. Serum levels of BDNF, Irisin and Cathepsin B were measured by ELISA. To analyze the data, paired samples t-test was used. Also, the percentage of changes were compared to pre-test.
Results: The results showed that in both environments serum levels of BDNF (p=0.001, p=0.001) Irisin (p=0.002, p=0.001) and Cathepsin B (p=0.001, p=0.0005) were significantly increased. However, there was only a significant difference between Irisin (p=0.043) and Cathepsin B (p=0.046) in the two environments. Also, the percentage of changes in all variables was higher in enriched environment.
Conclusion: Moderate intensity aerobic exercise in healthy active adolescents increased serum levels of BDNF, Irisin, and Cathepsin B. But, the manipulated environment has greater impact. Therefore, it is recommended to use a manipulated environment to make the most of the beneficial effects of aerobic exercise.
Leila Fasihi, Bakhtyar Tartibian, Rasoul Eslami,
Volume 23, Issue 0 (11-2021)
Abstract
Background and Aim: Middle-aged women experience changes in bone density due to the transition to menopause. The process of bone measurement and analysis can be continuously controlled by measuring the biochemical markers of bone circulation. Therefore, the aim of this study was to evaluate the status of osteoporosis using serum osteocalcin and alkaline phosphatase in active middle-aged women.
Materials and Methods: A total of 50 active premenopausal women, 46 active menopausal women and 55 active postmenopausal women in the age range of 35-65 years and an average weight of 57.13 kg with medical records and clinical trials were selected and available at Ayatollah Kashani Hospital in Tehran. One-way ANOVA and Scheffe post hoc test were used to examine the differences between the groups and Pearson correlation coefficient was used to find the relationship between the indicators and bone mineral density. Data analysis was performed using SPSS software version 26 (P≤0.05).
Results: The results of the present study showed that the level of mineral density of femoral neck and lumbar vertebrae before menopause was significantly different from during menopause and after menopause (P≤0.05), and the lowest decrease was observed before menopause. Also, serum levels of osteocalcin and bone-specific alkaline phosphatase were significantly increased in both groups during menopause and after menopause (P≤0.01).
Conclusion: The results showed high serum levels of serum osteocalcin and alkaline phosphatase in both menopausal and postmenopausal women. Given that these indicators are one of the main factors determining the premature decrease in bone mineral density in middle-aged women, it can be said that one of the applications of the present study is to use the value of these indicators in predicting bone mineral density and possibly He used these blood variables to identify active women aged 35 to 65 years at risk for osteoporosis.
Background and Aim: Middle-aged women experience changes in bone density due to the transition to menopause. The process of bone measurement and analysis can be continuously controlled by measuring the biochemical markers of bone circulation. Therefore, the aim of this study was to evaluate the status of osteoporosis using serum osteocalcin and alkaline phosphatase in active middle-aged women.
Materials and Methods: A total of 50 active premenopausal women, 46 active menopausal women and 55 active postmenopausal women in the age range of 35-65 years and an average weight of 57.13 kg with medical records and clinical trials were selected and available at Ayatollah Kashani Hospital in Tehran. One-way ANOVA and Scheffe post hoc test were used to examine the differences between the groups and Pearson correlation coefficient was used to find the relationship between the indicators and bone mineral density. Data analysis was performed using SPSS software version 26 (P≤0.05).
Results: The results of the present study showed that the level of mineral density of femoral neck and lumbar vertebrae before menopause was significantly different from during menopause and after menopause (P≤0.05), and the lowest decrease was observed before menopause. Also, serum levels of osteocalcin and bone-specific alkaline phosphatase were significantly increased in both groups during menopause and after menopause (P≤0.01).
Conclusion: The results showed high serum levels of serum osteocalcin and alkaline phosphatase in both menopausal and postmenopausal women. Given that these indicators are one of the main factors determining the premature decrease in bone mineral density in middle-aged women, it can be said that one of the applications of the present study is to use the value of these indicators in predicting bone mineral density and possibly He used these blood variables to identify active women aged 35 to 65 years at risk for osteoporosis.
Zahra Eslami, Yahya Mohammad Nezhad Panah Kandi, Mahbanou Ghaderi, Abdorreza Eghbal Moghanlou, Shohreh Sharifian, Gheysar Beyshami, Seyed Javad Mirghani,
Volume 25, Issue 3 (11-2023)
Abstract
Background: Strategies to increase energy expenditure are an attractive approach to reduce excess fat storage and body weight to improve metabolic health. The aim of the present study was to investigate the effects of endurance training combined with adenosine injection on the gene expression of UCP-1 and MAPK p38 in the subcutaneous adipose tissue of male rats fed a high-fat diet.
Materials and Methods: Forty rats were randomly divided into 4 groups: 1. normal control, 2. high-fat diet (HFD) control, 3. HFD + adenosine, and 4. HFD + endurance training + adenosine. After 13 weeks of HFD, 12 weeks of endurance training on a moderate-intensity treadmill was performed. UCP-1 and MAPK p38 mRNA levels were measured by RT-PCR.
Results: A significant increase in UCP-1 was observed with in HFD + endurance training + adenosine and HFD + adenosine compared to normal and HFD controls. A significant decrease in MAPK p38 was also observed with HFD + endurance training + adenosine and HFD + adenosine compared to HFD.
Conclusion: Endurance training and adenosine are likely activators of UCP-1 gene expression and can be used as effective lipolytic agents in obesity. The MAPK p38 pathway increases glucose uptake by insulin and also induces oxidative phosphorylation in mitochondria following a healthy diet and aerobic activity.
Farkhondeh Garavandpour, Vahid Valipour Dehnou, Rasoul Eslami,
Volume 26, Issue 4 (10-2024)
Abstract
Background: Type 2 diabetes is the most common chronic disease characterized by insulin resistance and disruption of glucose membrane transport mechanisms. It has been shown that GLUT5 and AS160 proteins play a role in this mechanism. Therefore, the aim of the present study was to investigate the effect of endurance training on the levels of GLUT5, AS160, and insulin resistance in the extensor digitorum longus (EDL) muscle of type 2 diabetic rats.
Materials and Methods: A total of 30 adult male laboratory mice were randomly divided into 3 groups: control (C), diabetes (D), and diabetes training (DT). Diabetes was induced by streptozotocin (35 ml/kg) injection and a high-fat diet. Endurance training consisted of five sessions of treadmill running each week for 8 weeks. EDL muscle extraction was done 48 hours after the last training session. The enzyme-linked immunosorbent assay method was used to measure proteins. To analyze the data, a one-way analysis of variance was used at a significance level of 0.05.
Results: There was no significant difference between GLUT5 levels in all groups (P=0.94). However, AS160 levels were higher in the C group than in the other two groups (P=0.001). Moreover, AS160 levels were significantly higher in the DT group than in the D group (P=0.001). There was no significant correlation between GLUT5 and AS160 (r=0.02, P=0.94).
Conclusion: Endurance training, by compensating the destructive mechanisms of diabetes, reduces hyperglycemia and overexpression of AS160 protein levels in EDL muscle; however, it does not affect GLUT5 protein levels. Therefore, it seems that endurance training plays a role in modulating the damaging effects of diabetes in skeletal muscles through mechanisms other than increasing GLUT5, such as changes in AS160.
