Showing 9 results for Goodarzi
Hamid Foroughipour, Korosh Goodarzi,
Volume 19, Issue 5 (2-2018)
Abstract
Background: Behavioral disorders in preschool children causes a lot of problems. They mainly use medical treatment to solve this problem. But this research looks for a non-pharmacological alternative through the educational games.
Materials and Methods: Data were gathered through randomized controlled trial method by using unequal control group design with pre-post test plan. The sample included 46 six years old girls. They were slected from a kindergarten in Boroujerd city, and through the creation of a random sequence divided to two groups, 24 as experimental and 22 as control groups. The instrument was (PKBS) observation form in behavior disorders status.Data were analyzed by independent and dependent T tests .
Results: The results showed that there is a significant difference between the mean of the pre-test and post-test in internal (p≥0.0001) and external behavioral disorders (p≥0.0001) of preschool girls. Independent T test showed that there is significant difference between post-test of internal (p≥0.05) and external (p≥0.01) behavioral disorders of experimental and control groups to benefit of experimental group. There is no significant difference between pre-test and post-test of internal (p≥0.69) and external (p≥0.23) behavioral disorders in the control group.
Conclusion: According to the results the educational games showed significant effect on the improvement of behavioral disorder of preschool girls, therefore, it is approprate to apply the games as a non-pharmacological program in the relevant centers for children with behavioral disorders.
Mohsen Rezaee, Ali Farhadi, Korosh Goodarzi,
Volume 22, Issue 3 (11-2020)
Abstract
Background: In general, a healthy work environment can be closely related to the mental health of its employees. All jobs, even the seemingly easy ones, have breathtaking moments of responsibility and expectation. Prolonged job stress and work pressures will eventually lead to mental disorder. The aim of this study was to compare the effectiveness of social skills training and group therapy based on commitment and acceptance on self-esteem and social phobia disorder.
Materials and Methods: The research method was quasi-experimental and pre-test-post-test design was equal to the control group. The statistical population of the study was all employees working in government offices in Arak in the second half of 1397. Among the statistical population, available and targeted sampling method for 1300 eligible people (age 25 to 60 years, no history of mental illness) Connor (2000) and Cooper-Smith (1967) self-esteem questionnaire were administered to this number. Of these, 45 people who had the lowest score in the tests were randomly selected into two experimental groups and one control group (15 people in each group). Then, intervention was performed for the volunteers of the experimental groups (social skills training and group therapy based on commitment and acceptance). Data were analyzed by SPSS software and multivariate analysis of covariance and Bonferroni post hoc test at a significance level of 5%.
Results: The results showed that social skills training and treatment based on commitment and acceptance significantly increased self-esteem and decreased social fear (p <0.001). Also, no significant difference was observed between the two treatments (p <0.001).
Conclusion: According to the research findings, social skills training methods and treatment based on commitment and acceptance can be used as an effective method to reduce social fear and increase self-esteem in employees.
Ali Hatami Bardar, Mohsen Azimi Nejad, Mojtaba Jafarinia, Hamid Reza Goodarzi, Majid Mojarrad,
Volume 22, Issue 4 (1-2021)
Abstract
Background: The hurler syndrome is the most common form of lysosomal storage diseases (LSDs). In the present experiment, we intended to generate an IDUA targeting CRISPR-Cas system and deactivate the target gene using it.
Materials and Methods: IUDA targeting sgRNA pair were cloned into the px335 plasmid and resulted plasmid identity was confirmed using restriction mapping. Recombinant plasmid was transfected into the human epithelial cell line, HEK-293. Mutated clones were screened by melting analysis and their mutation was characterized by Sanger sequencing.
Results: Analytical digestion and Sanger sequencing confirmed indel mutation induction in two clones in heterozygote and one clone in homozygote state.
Conclusion: In this study, we produced an IDUA knockout cell model using CRISPR-nCas9 system. This model can be used in the therapeutic approaches of this disease.
Bijan Goodarzi, Dr. Masoud Mirmoezzi, Mohammad Heidarinia, Yasman Goodarzi,
Volume 23, Issue 0 (11-2021)
Abstract
Background: One of the most common knee ligament injuries is anterior cruciate ligament (ACL) rupture which is associated with limited range of motion (ROM). Therefore, the aim of this study was to determine the one preoperative kinesiotherapy cycle in relieving knee pain, increasing knee strength and range of motion in patients with ACL injury.
Materials and Methods: In this clinical trial study, 20 male male patients with ACL injury ranging in age from 17 to 29 years were divided into two intervention groups of kinesiotherapy (n = 11) and control (n = 9). The kinesiotherapy group underwent three sessions per week for 8 weeks. Pain variables, isokinetic strength of knee extensor muscles and knee joint ROM were measured by visual Analogue scale (VAS), goniometer and biodex dynamometer before and after the treatment, respectively. Data were analyzed using Student's t-test at the significant level of p <0.05.
Results: After a period of kinesiotherapy, the mean pain index, maximum quadriceps muscle torque and knee joint ROM improved in the kinesiotherapy group (P <0.05).
Conclusion: Using appropriate kinesiotherapy programs to improve the strength and knee joint ROM; can be a quick solution for athletes with ACL rupture before surgery.
Keywords: Kinesiotherapy, Knee strength, ACL injury, Knee range of motion, knee pain.
Maryam Mousavi, Mojtaba Fathi, Mohammad Taghi Goodarzi, Seyed Mehrdad Kassaee, Ali Jafari Heidarloo,
Volume 23, Issue 4 (9-2021)
Abstract
Background: Colorectal cancer is one of the most common gastrointestinal cancers worldwide with a high prevalence among middle-aged people. This study aimed to evaluate and compare changes in serum levels of carcinoembryonic antigen (CEA) and carbohydrate antigen 19-9 (CA19-9), as two important tumor markers, in the diagnosis of different stages of colorectal cancer.
Materials and Methods: This basic research was conducted on hospitalized patients with colorectal cancer (n=67). At first, tissue samples and venous blood samples were collected from patients. Subsequently, CEA and CA19-9 tumor markers were measured by enzyme-linked fluorescence assay and cellular changes were investigated by hematoxylin and eosin staining.
Results: In this study, 57.6% and 43.3% of the patients were male and female, of which 59.7% (40 patients) cases were over 61 years old. The most common sites of tissue involvement were found to be the rectum and sigmoid. In the acute phase of the disease, a decrease was observed in the number of red blood cells (P=0.0091) and the level of hemoglobin (P=0.141); however, the number of platelets remained unchanged (P=0.212). In addition, lymphocyte and neutrophil counts increased at first, while they decreased later. The findings showed that there was a significant relationship between these two tumor markers and disease levels.
Conclusion: Our results indicated that although these tumor markers are not suitable factors for the diagnosis of this cancer in the early stages, they can be used as two important markers to diagnose the progression of the disease.
Saeed Zargari, Abbas Bahari, Mohammad Tagi Goodarzi, Minoo Mahmoodi, Reza Valadan,
Volume 23, Issue 5 (1-2022)
Abstract
Background: Gastric cancer (GC) is the second most common malignancy and the leading cause of death in Iran.. According to global statistics, these figures are highly worrying highlighting the importance of studies in this field. Given that the role of chronic inflammation in the development of cancer, especially infection-related cancers, such as GC, has been revealed for many years, evaluating the molecules involved in these processes can be helpful. Toll-like-receptors (TLRs) as the greatest family of receptors for inflammation-associated molecular patterns, and the effect of mutations in TLR2 and TLR4 on the pathology of GC has been identified. Considering the results of previous studies and the major role of TLR2 and TLR4 in inflammatory processes of pre-malignancy, in this study, the mutation in the sequence of these genes and its association with GC have been investigated in both laboratory and bioinformatics stages.
Materials and Methods: In this study, 30 Helicobacter pylori-positive GC samples were collected and after DNA extraction using Sanger sequencing methods, and subsequently, variant pathogenicity predictions, such as SIFT and PolyPhen, mutation pathogenicity was predicted. Following that, PyMOL was applied to model 3D structures of the wild and mutated receptor.
Results: Sanger sequencing data showed a heterozygous mutation in exon 3 of TLR4 c.1061A>G. The modeling crystal structure of the human receptor and LPS complex showed that the variant was far from the TLR4 binding sites with its ligand.
Conclusion: The results of this study indicated that mutations in two important genes of the pattern recognition system in Iranian cancer samples have no functional relevance with these two proteins.
Katayoun Bakhtiar, Zeinab Moradian Haft Cheshmeh, Rasool Mohammadi, Fataneh Goodarzi, Fatemeh Bastami,
Volume 24, Issue 3 (12-2022)
Abstract
Background: Due to usually late diagnoses, breast cancer is accompanied by a high mortality rate. Breast self-examination increases the success of treatment and survival rates. This study aimed to evaluate the knowledge and practice of postmenopausal women residing in Khorramabad, Iran, about breast self-examination.
Materials and Methods: The present descriptive-analytical study was performed on 333 postmenopausal women referring to health centers in Khorramabad in 2019. The participants were selected using cluster sampling. The required data were collected using a questionnaire containing items on demographic characteristics as well as variables of knowledge and practice of breast self-examination. Data analysis was performed in SPSS software version 22 using the Spearman correlation coefficient, the Chi-square test, and Fisher's exact test.
Results: The mean age of the subjects was 55.13±8.13. It was found that 55% of women had moderate knowledge and 43.8% had a moderate performance. The most common source of information was through health center staff (52.9%). Knowledge and performance showed a direct and significant correlation with breast self-examination (r=0.530, P<0.001). There was a statistically significant relationship between knowledge and performance on the one hand, and visiting a doctor and having a history of attending classes on the other (P<0.05). There was also a statistically significant relationship between performance and marital status (P<0.05).
Conclusion: Due to the significant relationship between knowledge and performance variables and behaviors such as attending classes and visiting doctors, it is recommended to design educational programs to encourage postmenopausal women to perform breast self-examination.
Fatameh Foladi, Ali Farhadi, Kourosh Goodarzi,
Volume 24, Issue 3 (12-2022)
Abstract
Background: Child abuse and neglect are global problems with negative outcomes in the quality of life among children. This study aimed to investigate the effectiveness of cognitive-behavioral group training on child-abuser mothers and the quality of life of children.
Materials and Methods: This interventional study was conducted based on a pretest-posttest design and a control group. The statistical population of this study included all preschool children in kindergartens in Khorramabad, Iran. Using the cluster sampling method, 23 children who gained the abuse score were selected, along with their mothers were selected and randomly divided into an experimental (n=10) and a control (n=13) group. The mothers in the experimental group received cognitive-behavioral training for eight 90-minute sessions. The tools used to collect data consisted of the Child Abuse Scale (Mohammadkhani, 2011) and the Quality of Life Questionnaire (Fakkes, 2000). The gathered data were analyzed in SPSS software (version 22) using descriptive statistics, the Chi-square test, and the Mann-Whitney U test at a significance level of <0.05.
Results: The data analysis of this study showed that group cognitive-behavioral training had a significant effect on the reduction of all dimensions of mother’s child abuse (P<0.05) and a positive effect on evaluating the quality of life of children from their mother's point of view (P<0.05).
Conclusion: In general, the results of the study indicated that cognitive-behavioral training was effective in reducing mothers’ child abuse and improvement of the quality of life of preschool children.
Amin Ghanbariani Gandom Bani, Mohamad Fathi, Rahim Mirnasouri, Elham Goodarzi,
Volume 26, Issue 2 (6-2024)
Abstract
Background: Physical activity with anti-inflammatory and antioxidant effects can play a critical role in the health of individuals. Therefore, the present study aimed to assess the impact of resistance training and curcumin consumption on inflammatory indicators and oxidative stress in obese men.
Materials and Methods: The present study was conducted based on a quasi-experimental design. The studied population consists of obese men aged 38-43 years. The sample size was estimated to be 40 individuals, who were randomly assigned to four groups of 10 using a random number table. The training program lasted for eight weeks, with three sessions per week. An 80 mg curcumin supplement was administered. Blood samples were collected before and after the final session. Data analysis involved one-way analysis of variance, paired t-test, and Tukey's post hoc test at a significance level of 0.05.
Results: The amount of catalase enzyme in resistance training groups (P=0.012), curcumin supplement (P=0.032), and resistance training group with curcumin consumption (P<0.001) were associated with a significant increase. Nonetheless, it was not significant in the control group (P=0.991). Furthermore, the levels of malondialdehyde, interleukin-6, C-reactive protein, and tumor necrosis factor-alpha in the experimental groups displayed a significant decrease (P<0.05), whereas these changes were not significant in the control group (P<0.05).
Conclusion: As evidenced by the obtained results, it can be stated that the consumption of curcumin may be effective in suppressing the inflammation caused by obesity. This is due to its potent antioxidant effects and its combination with resistance training.
