Showing 5 results for Hematfar
Hoseyn Dalvand, Ahmad Hematfar, Naser Behpoor,
Volume 21, Issue 1 (5-2019)
Abstract
Background: Curcumin is an active ingredient in turmeric, which is used as herbal medicine for the treatment of certain diseases. The aim of this study was to investigate the effects of two weeks of exhaustive swimming and supplementation of curcumin on alcohol induced liver damage biomarkers in male wistar rats.
Materials and Methods: In this study, 32 male wistar rats were randomly selected and divided into 4 equal groups: control, training, supplemental curcumin, and training with curcumin supplement. At first, every 8 hours for 4 days, alcohol was gavaged to all groups, proportional to the body weight of each rat. This was followed by an alcohol withdrawal period. After that, the practice period began, including long-term swimming in water, for the exercise group, and the curcumin supplement with exercise group. Finally, blood samples were taken from the heart under anaesthetic
Results: Curcumin had no significant effect on AST (P = 0.401) and ALT (P = 0.978) and the ratio of these two enzymes (p = 0.657). Exercise significantly reduced AST (P = 0.022), but did not significantly decrease ALT (P = 0.759) or the ratio of these two enzymes (p = 0.225). Exercise and supplementation interaction did not significantly decrease ALT (P = 0.462) or AST (P = 0.073) activity or the AST / ALT ratio (P = 0.520).
Conclusion: The reduction of liver damage markers in this study suggests that exercise and curcumin consumption may, through protective effects, improve the negative effects of alcohol on the liver, and prevent alcohol induced liver disease.
Ahmad Kazemi, Nasser Behpour, Ahmad Hematfar,
Volume 22, Issue 2 (8-2020)
Abstract
Background: The incidence of heart disease increase with age. Green tea is an antioxidant which can prevent cellular aging. Therefore, the present study aims to investigate the effect of 12 weeks of green tea extract consumption on total antioxidant capacity (TAC), malondialdehyde (MDA) levels and superoxide dismutase, glutathione peroxidase and catalase activity of old rats' heart tissue in response to acute exhaustive exercise.
Materials and Methods: 32 male rats were randomly categorized into two groups of supplement and non-supplement each consisting of 16 rats. The supplement group received green tea extract for 12 weeks. At the end of the 12 weeks, each of these groups was further divided into two groups of rest and acute exhaustive exercise. The non-supplement with the rest group was called control group. The non-supplement with exercise group was called exercise group. Further, the supplement group with the rest was called supplement group and finally the last group was entitled supplement with exercise. After 12 weeks of taking green tea extract, one session of acute exhaustive exercise was held on the treadmill. Sandwich ELISA method was used to measure TAC and MDA content and superoxide dismutase, glutathione peroxidase and catalase activity
Results: The results showed that 12 weeks of green tea extract consumption increased TAC and decreased MDA levels. Furthermore, increased superoxide dismutase, glutathione peroxidase and catalase activity in response to a bout acute exhaustive exercise.
Conclusion: According to the results of this study, 12 weeks of green tea extract consumption can increase TAC levels and increase the activity of antioxidant enzymes at rest and after acute exhaustive exercise.
Abdollah Bagheri, Ahmad Hematfar, Mehdi Roozbahani, Naser Behpour,
Volume 22, Issue 4 (1-2021)
Abstract
Background: The aim of the present study was to investigate the effect of exercise pre-conditioning with intense intermittent exercise on MDA, SOD and GPx enzymes of myocardial infarction following acute myocardial infarction in male rats.
Materials and Methods: Based on this goal, 20 8-week-old male Wistar rats (mean weight 224.41 ± 5.1 g) were divided into 4 groups: control, training, stroke and stroke-training. The training groups performed two weeks of intense intermittent training in four sections. The first part of three days of training, two sessions per day and each session consisting of 4 intense two-minute intervals at a speed of 35 to 40 meters per minute . In the second part, two training days, two training sessions each day containing 4 cycles of intense activity of 2 minutes and 3 cycles of active rest of 2 minutes. The third part, in three training days, included 5 intense cycles and 4 active rest cycles. The fourth part consisted of two training days with the same intensity as the third part but with an increase in the frequency of activity and active rest in each session.
Results: One-way analysis of variance test showed that two weeks of intense intermittent training, although reducing the heart attack area of rats, however, it did not cause significant changes in MDA, SOD and GPx enzymes following acute myocardial infarction between stroke-exercise and stroke groups.
Conclusion: Intense intermittent exercise reduces heart damage in myocardial infarction, and this reduction occurs independently of changes in oxidative and antioxidant factors.
Abdollah Bagheri, Ahmad Hematfar, Mahdi Roozbahani, Naser Behpur,
Volume 23, Issue 0 (11-2021)
Abstract
Background: Apoptosis plays an important role in the development of cardiovascular complications, especially acute myocardial infarction. Evidence suggests that exercise can alter the pathways of myocardial apoptosis. Therefore, the aim of this study was to determine the effect of two weeks of intense intermittent exercise on Bax, Bcl-2 and Caspas-3 in the heart tissue of male rats.
Materials and Methods: 20 male Wistar rats aged 8 weeks (mean weight 224.41 5 5.1 g) were randomly divided into 4 groups: control, training, stroke and stroke-training. The training groups performed two weeks of intense intermittent training in four sections. The first section received two sessions three days a week, each session consisting of four intense two-minute intervals at a speed of 35 to 40 meters per minute, with an active 2-minute rest interval between the two rotations. The exercises of the second part included two days a week, two sessions each day containing 4 intense 2-minute intervals and 3 2-minute active rest intervals. The third section, on three days a week, included 5 intense cycles and 4 active rest cycles. The fourth part consisted of two days a week with the same intensity as the third part, but with an increase in the frequency of activity and active rest in each session. Finally, Bax, Bcl-2 and Caspas-3 proteins were measured using ELISA kit in blood samples taken from heart tissue and the data obtained using the analysis of variance were measured. Paths were analyzed at a significance level of 0.05.
Results: There was a significant decrease in Bax and Caspas-3 indices between exercise-stroke and stroke groups (P = 0.000), but Bcl-2 index in exercise-stroke group increased significantly compared to stroke group. (P = 0.000) was associated.
Conclusion: Based on the results of the present study, performing 2 weeks of intense intermittent exercise reduces apoptosis and myocardial infarction and can protect the heart from possible injuries.
Bagher Soheili, Syed Ali Hoseini, Ahmad Hematfar,
Volume 25, Issue 2 (8-2023)
Abstract
Background: Aging can lead to a decrease in cardiac function and an increase in oxidative stress in the heart, which leads to cellular aging through mitochondrial dysfunction. The present study aimed to investigate the antioxidant effects of high-intensity interval training (HIIT) and genistein (Ge) consumption in the heart tissue of elderly rats.
Materials and Methods: In this experimental study, 30 female Sprague-Dawley rats aged 18 to 24 months were selected and divided into five groups of six rats, including 1) HIIT, 2) Ge, 3) HIIT + Ge, 4) control, and 5) sham. During eight weeks, groups 2 and 3 received 60 mg of Ge dissolved in DMSO per kilogram of body weight daily, and group 5 received 60 mg of DMSO per kilogram of body weight per day intra-peritoneally. In addition, groups 1 and 3 ran on the treadmill three times per week. For statistical analysis of data, Shapiro-Wilk, independent samples t-test, one-way ANOVA, and Tukey's post-hoc test were used.
Results: High-intensity interval training had a significant effect on increasing GPx and MDA (P<0.05), Ge led to a significant decrease in SOD (P<0.05); however, HIIT with Ge had not interactive effects on improving SOD, GPx, and MDA (P<0.05).
Conclusion: It seems that the antioxidant system is dependent on the intensity of exercise and the dose of genistein. Therefore, HIIT and Ge in this study have no interactive effect on the oxidant-antioxidant system in the heart of elderly rats.
