Mohsen Towliat Kashani, Shaban Mehrvarz, Farzad Panahi,
Volume 5, Issue 1 (1-2004)
Abstract
Introduction: Effects of high velocity bullet in Abdominal wall injuries specially the blast effect on intra abdominal organs needs mandatory explorative laparatomy to manage any major and minor injuries . Usually many explorative laparatomies are negative , but it can be reduced by advanced radiologic techniques such as ultrasonography ,CT – Scan , MRI preoperatively.
In patients with negative physical examination to diagnose any intra abdominal bleeding , or gastrointestinal tract perforations , other techniques are suggestive for selective non-operative management.
Materials & Methods: This is a review article study .We searched all Medline, surgery and trauma text books.we have analyzed the advantages and disadvantages of the selective non-operative managements.
Findings and Conclusion : Because of today affinity to conservative and non aggressive management , many surgeons try to manage the abdominal trauma by conservative management. We found satisfied results in our study , we found that if we manage these patients in a trauma center , the selective non operative management for abdominal gunshot wounds would be a safe way , reduces hospital costs , and stops the unnecessary laparatomies.
We should be enough careful to approve the selective non-operative management in next clinical trials studies.
Siavash Masoumi Jouibari, Maedeh Barahman, Mahshid Panahi, Alireza Nikoofar, Soheila Sayad,
Volume 23, Issue 0 (11-2021)
Abstract
Introduction: Breast cancer is the most common cancer in Iran based on age standardized incidence. Multidisciplinary approach including surgery, pathology, chemotherapy and radiotherapy in treatment of this cancer is of a great importance. In this study, we intend to investigate 2-year relapse free survival and the measure of tumor free safe margin in the breast conservation surgery patients undergoing multidisciplinary treatment.
Methods: This study was conducted in Firoozgar hospital of Tehran. Patient were imported to the study by census from May 2016 to September 2018 and followed up by September 2020. For the patients, superior, inferior, lateral, medial, anterior and deep margins were measured in lumpectomy samples. In addition, 2-year relapse was reported based on Poisson distribution.
Results: In this study, 156 cases were initially selected by census that 81 of them were breast conservation surgery. The mean of safe margin was 1.73 superior, 2.02 inferior, 2.30 lateral, 2.41 medial, 1.49 anterior and 1.27 deep. Only one case of local recurrence was observed (relapse free survival = 98.77%).
Conclusion: Enough safe margin along with a multidisciplinary treatment approach was associated with the 98% relapse free survival which was more than previous studies. It seems that lower amounts of margin could also be associated with lower recurrence, but it is more important to use specialists of different majors to manage the patients. This approach is suggested to be used in future.
Shshram Hassanpour, Nooshin Naghsh, Nasrin Yazdanpanahi, Nasrin Talebian,
Volume 25, Issue 3 (11-2023)
Abstract
Background: Diabetes is a recurrent disease defined as a result of a lack of insulin or resistance to its full capacity. The present study aimed to assess the effect of ginger-zinc oxide nanocomposites on HbA1c and fasting blood sugar (FBS) indexes in diabetic rats.
Materials and Methods: In this investigation, zinc oxide nanoparticles were synthesized based on the sol-gel method, and ginger extract was obtained using the soxhlet method. Thereafter, the nanocomposite of nanoparticles-ginger extract was synthesized, and the nanoparticles were identified by confirmatory tests. Diabetes was induced in male Wistar rats with a mean weight (250±20 g) by intraperitoneal injection of streptozotocin (60 mg/kg body weight), and the necessary treatments were then given by gavage to the mice for 30 days. At the end of the treatment period, hemoglobin A1c (HbA1c) and fasting blood sugar (FBS) were measured from the collected blood samples.
Results: The results of this research demonstrated that among all the treatments, nanocomposite extract and zinc oxide nanoparticles in low concentration (100+10 mg/kg) have a high ability to reduce blood sugar indicators (HbA1c and FBS). This ability was statistically significant compared to other treated groups (P<0.05).
Conclusion: As evidenced by the results obtained, the nanocomposite of ginger extract + zinc oxide in the concentration (100 +10 mg/kg) was a suitable option for controlling and reducing blood sugar in mice. Furthermore, considering the physiological similarity, the mentioned nanocomposite is recommended as a supplement to lower blood sugar in diabetic people.
Keywords: Diabetes, Ginger, Zinc oxide nanoparticles, HbA1c, FBS.
