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Showing 9 results for Sohrab
Comparing the Efficacy and Adverse Effects of Citalopram with Nortriptylinee in the Treatment of Major Depressive Disorder
Hedayat Nazari , Mandana Saki , Parisa Sohrabi , Mohammad Javad Tarrahi , Mohammad Movahedi , Afsaneh Badrizadeh , Kheirollah Baqeri ,
Volume 9, Issue 3 (Yafteh 2007)
Abstract

Nazari H1, Saki M2, Sohrabi P3, Tarrahi MJ4, Movahedi M5, Badrizadeh A6, Baqeri Kh7

1. Assistant Professor, Department of Psychiatry, Faculty of Medicine, Lorestan University of Medical Sciences

2. Instructor, Department of Psychiatry, Faculty of Nursing and Midwifery, Lorestan University of Medical Sciences

3. General Practitioner, Neurology and Psychoiatry Hospital, Khorramabad

4. Instructor, Department of Epidemiology and Statistics, Faculty of Medicine, Lorestan University of Medical Sciences

5. Assistant Professor, Department of Epidemiology, Faculty of Medicine, Lorestan University of Medical Sciences

6. B.Sc of Nursing, Staff Member of Research and Technology Office, Lorestan University of Medical Sciences

7. B.Sc of Nursing, Psychology hospital

Abstract

Background: Major depressive disorder (MDD) is one of the most common mental disorders all over the world. An effective treatment preserves an acceptable level of function in the affected patients. Different drugs are used in the treatment of MDD, and each of them has specific therapeutic and adverse effects. Recently, SSRI drugs are used in the treatment of this disorder, and yet there is not enough study about them. Thus, we decided to compare the effectiveness and adverse effects of Nortriptyline with that of Citalopram in MDD.

Materials and methods: In this double-blinded clinical trial, 80 MMD (DSM-IV-TR) patients, who that not any other mental, substance and organic disorders were selected. Samples were randomly assigned into two groups which were treated with Nortriptyline or Citalopram. Efficacy and adverse effects were evaluated at 2, 4, 6, 8 and 12 weeks after the treatment. Data were analyzed by SPSS software.

Results: Efficacy was similar in two groups, and no significant differences between the two groups were observed in the mean scores. The comparison of adverse effects between the two groups showed a significant difference in the hypersomnia, dry mouth, anorexia and nausea. There was not a significant difference between the two groups in the sexual dysfunction, insomnia headache, tremor, vertigo, obesity, diarrhea, vomiting and abdominal pain.

Conclusion: Tricycles and SSRI drugs have an equal efficacy in the treatment of MDD. But they have different adverse effect profiles, thus they must be administrated with an attention to their adverse effects.


Determination of Sialyl trnsferase activity and effect of Phosphorylation and dephosphorylation Mechanisms
Sohrab Halakhor , D Qujeq , Ramin Shikhpour ,
Volume 10, Issue 3 (yafte 2008)
Abstract
Halakhor S1, Qujeq D2, Shikhpour R3 1. Instructor, Department of Biochemistry and Biophysics, Faculty of Medicine, Babol University of Medical Sciences, Babol, Iran 2. Associate professor, Department of Biochemistry and Biophysics, Faculty of Medicine, Babol University of Medical Sciences, Babol, Iran 3. GP, Babol, Iran Abstract Background: Previous reports show that phosphorylation anddephosphorylation mechanisms involve in regulation of sialyl transferaseactivity. The aim of this research was to study sialyl trnsferase activity with phosphorylation and dephosphorylation mechanisms. Materials and methods: This experimental trial study performed on 25 rats without signs of illness. Rat brains were pulled out and brain homogenization was done and then sialyl transferase purified purified from rat brain. Homogenization of rat brain is performed in the cephadex chromatography. We added protein kinaseokadaic acid and forbol to different groups. Data were statistically analyzed using SPSS soft wave. Results: Results showed a significant increase in sialyl transferase activity in the control group, comparing with protein kinase C and okadaic acid groups.Results showed a significant decrease in sialyl transferase activity incontrol group, comparing with protein phosphatase and forbol groups. Conclusion: Our findings show that sialyl transferase of rat brain with protein kinase decreases enzyme activity and these results were in accordance with other studies in this respect. We found that treatment of rat brain sialyl transferase by protein phosphatase increases its activity.
The relationship between obesity and serum total cholesterol, LDL cholesterol, HDL cholesterol and triglyceride level in men 18-34 years old living in district 6 of Tehran: comparison of BMI,waist and waist to hip ratio
Masoud Kimiagar, Golbon Sohrab , Mahvash Hemat , Banafshe Golestan,
Volume 13, Issue 3 (12-2011)
Abstract
Background : Cardiovascular diseases are among the most important causes of mortality and major health problems in developed as well as developing countries including Iran. This study aimed to develop percentile reference data for serum lipids including total cholesterol, low density lipoprotein cholesterol, high density lipoprotein cholesterol and triglyceride and to determine the prevalence of overweight and fat distribution in male adults living in Tehran. Materials and Methods: The study population consisted of 141 men aged 18-34 years living in district 6 of Tehran.According to list of primary schools located in district 6 of Tehran, subjects were chosen from residents around these schools. Sociodemographic and anthropometric questionnaires were filled in at the subjects' home. They were asked to attend the study center the next day at 8:00-8:30 am and 5 ml of fasting blood (at least 12 hours) was collected from each subject. Data statistical analysis was performed using SPSS software Ver 11.5. Chi square test was used for qualitative variables and Pearson correlation was calculated for quantitative variables. Results: Data showed 24.8% hypercholesterolemia, 29.8% hypertriglyceridemia, 21.3% LDL>130mg/dl and 36.2% HDL<40mg/dl in the subjects. BMI was positively and significantly correlated with total cholesterol, triglyceride and low density lipoprotein cholesterol but no significant correlation was observed for waist circumference and waist to hip ratio with blood indices. Conclusion: The study shows that BMI can be a predictive factor for cardiovascular disease in Iranian population. In order to clarify waist circumference and waist to hip ratio correlations with and blood lipids and also to develop percentile reference data for blood lipids, more studies with larger study population is recommended.
Feizolah Poursardar , Zabiollah Abbaspour , Sohrab Abdi Zarrin , Ali Akbar Sangari ,
Volume 14, Issue 1 (6-2012)
Abstract
Background : Positive psychology approach caused by changes in psychological science moves from addressing psychopathological damage treatment to optimization of life quality. This movement follows that strengths of humans as a shield against mental illness take advantage. Resilience, is a subset of the positive psychology approach that is regarded as an important role in coping with stress and threat to life and its adverse effects, So that during the past decade, has occupied a special place in the field of mental health. The current study aimed to investigate the effect of resilience on enhancing mental health and life satisfaction. Materials and Methods: In this cross-sectional-descriptive study, 178 participants (86 males and 92 females) of Ramshir teachers’ centers education organization, selected through randomized cluster sampling, participated in this study. All subjects completed Conner-Davidson Resilience Scale (CD-RIS), General Health Questionnaire (GHQ-28),Satisfaction with Life Scale(SWLS) and Demographic Inventory. Stepwise Multiple Regression analysis was used for statistical analysis. Results: Results of Hierarchical Multiple Regression method represented a significant intermediate role of mental health in the relationship between resilience (p<0/001) and life satisfaction (p<0/001). The participants’ mean and standard deviation of age were 32/16 and 5/70 respectively. Conclusion: Resilience positively affects life satisfaction through increasing mental health. Moreover, resilience has an indirect effect on life satisfaction.
The effectiveness of cognitive stimulation therapy on cognitive functions and quality of life in people with Alzheimer’s disease
Sohrab Yaghoubi Namin, Hasan Ahadi, Farhad Jomehri, Maryam Kalhornia Golkar,
Volume 21, Issue 2 (9-2019)
Abstract
Background: Alzheimer’s, the most common type of dementia, is a chronic and progressive degenerative disorder. It affects cognitive functions, social interactions, and quality of life. It is expected that by 2041, the elderly population in Iran will be around 25%. So, a cognitive stimulation therapy protocol has been introduced with a framework for maintaining cognitive abilities and improving quality of life. The purpose of this study was to investigate the effectiveness of cognitive stimulation therapy in cognitive function and quality of life in people with Alzheimer's disease.
Materials and Methods: the research method was a semi-experimental pre-test and post-test with a control group. 24 Alzheimer's patients who were residing in Tehran's elderly care and treatment centers were selected by available sampling. They were randomly assigned into two groups; an experimental group (interventional technique: cognitive stimulation therapy) and a control group. Measurement tools consisted of a MMSE cognitive test questionnaire, The Mini Cog test, CDR memory test, and QOL-AD questionnaire.
Results: results of multivariate covariance analysis showed that there was a significant difference between experimental and control groups in cognitive function and this showed that therapy is effective. Also, cognitive stimulation therapy, both directly and intermediately, increased the quality of life in the experimental group compared to the control group (P = 0.001).
Conclusion: Cognitive stimulation therapy, as an effective non-pharmacologic intervention, can be used to improve the cognitive status and quality of life in people with Alzheimer's disease.

The effectiveness of self-control strategies training on self-compassion and emotion regulation in adults suffering from attention deficit hyperactivity disorder
Sajad Naserinia, Mohammad Mehdi Sohrabi Fard,
Volume 21, Issue 3 (11-2019)
Abstract
Background: Attention deficit hyperactivity disorder (ADHD) is a neurodevelopmental disorder characterized by three main features, namely attention deficit, hyperactivity, and impulsivity. This study sought to determine the effectiveness of self-control strategic training on self-compassion and emotion regulation in adults suffering from attention deficit hyperactivity disorder in Khorramabad.
Materials and Methods: This research used a quasi-experimental method of pretest-posttest follow-up with a control group. The sample consisted of 30 men with attention deficit hyperactivity disorder in Khorramabad selected by available sampling and randomly assigned to the control and experimental groups. The experimental group received the self-control strategies for ten sessions, while the control group did not receive any intervention until the end of the project. The data were collected using Barkley Adult ADHD-IV Rating Scale (BAARS-IV), the self-compassion scale (SCS), and emotion regulation scale (ERS). The data were analyzed using multivariate analysis of variance.
Results: The results indicated that there were significant differences with regard to self-compassion and emotion regulation between the subjects of the experimental and control groups.
Conclusion: Self-control strategies training provides useful applied practices in the treatment and prevention of ADHD disorder in adults.

An investigation of the anti-tumor effect of the hydroalcoholic extract of zingiber officinale on the C6 glioma cell line
Hassan Sohrabian Kafraj, Abdolhosein Shiravi, Vida Hojati, Mojtaba Khaksarian, Maryam Alipour,
Volume 21, Issue 3 (11-2019)
Abstract
Background: Glioblastoma (GBM) is the most common malignant brain tumor in adults. Ginger has anti-tumor, anti-fungal, insecticidal, and anti-cancer properties. However, its anti-tumor effects on the C6 glioma cell line have not been examined. Hence, the anti-tumor effect of its hydro alcoholic extract has been investigated in the present study.
Materials and Methods: The hydro alcoholic extract of ginger was prepared. After the cultivation and proliferation of C6 glioma cells, they were exposed to concentrations of 100 to 1000 μg / ml for 24, 48 and 72 days, and the cell viability was determined by MTT method. Finally, the obtained data were analyzed using the one-way analysis of variance model.
Results: The results of MTT test showed that the hydroalcoholic extract of ginger could have dose and time-dependent anti-tumor effect on tumor cells. The highest percentage of cell death was observed with the increasing concentration of the extract and the extention of the incubation period up to 72 hours. The inhibitory concentration of cells growth (IC50) for tumor cells obtained for 24, 48, and 72 hours were 500.25, 611.118, and 733.33μg / ml respectively.
Conclusion: Since the hydroalcoholic extract of ginger in a dose and time-dependent manner inhibited the growth of C6 glioma cell lines, this extract might be effective in the treatment of brain tumors.


A Comparision of the Effect Neurofeedback on the Improvement of the Executive Functions of Individuals with ADHD and Epilepsy
Mojtaba Khaksarian, Saba Hasanvandi, Roghayeh Piri, Mohammad Mahdi Sohrabifard,
Volume 22, Issue 1 (4-2020)
Abstract
Background: Nowadays, neurofeedback is used as a new method to improve the symptoms of ADHD and epilepsy. The effectiveness of this new therapeutic approach in various disorders has been investigated. The purpose of this study was to compare the efficacy of this treatment in patients with hyperactivity and epilepsy.
Materials and Methods: This study was quasi-experimental with pretest and post test and the control group. The study population comprised all the children with ADHD and epilepsy in Karaj. The sample consisted of 60 infected children (15 indivuduals suffering from ADHD, 15 people with epilepsy and 30 controls) who were selected by the random sampling method. In the pre-test, the behavioral behavior (executive summary) for children was completed. This tool reflects the teacher's view of student behaviors in the field of executive functions. In fact, it provides a tool for screening the performance problems. Executable executive functions in this log include inhibition, flexibility, emotional control, initiation, work memory, planning / organizing, inventory management and monitoring. To conduct the research, the beta / theta program was used for all the subjects. The aim was to increase theta waves and decrease beta waves. After completing 10 sessions (5 weeks and 2 sessions per week), the neurofeedback was run and the log was re-entered. Descriptive statistics (mean and standard deviation) were used to analyze the data and the one-variable covariance method was used to infer the data. Spss version 18 was used to analyze the data.
Results: The findings of the research indicated that the performance scores in the pre-test and post-test of the studied groups were significantly different )P<0.001(. Moreover, the effect of neurofeedback treatment on the improvement of executive functions in the ADHD group was higher than the epileptic and control groups )P<0.001(.
Conclusion: Based on the findings, neurofeedback is efficient but its effect is different in patients with ADHD and epilepsy. Hence, the use of neurofeedback is more effective in improving the performance of ADHD patients. These results can be useful in the field of overactive treatment using novel methods.

Investigating Memory Reconsolidation as a Fundamental Mechanism of Therapeutic Change and a Link Between Neuroscience and Psychotherapy: A Narrative Review
Mohammad Mehdi Sohrabi Fard, Seyed Esmaeil Hashemi, Mahnaz Mehrabizaheh Honarmand, Soodabeh Bassak Nejad,
Volume 27, Issue 1 (12-2025)
Abstract
Background: Sustainable changes in psychotherapy are formed based on its underlying mechanisms. One of these key mechanisms is Memory Reconsolidation. This biological process involves updating and modifying memory information and is introduced as a fundamental mechanism of change in psychotherapy that leads to transformational changes. Therefore, the purpose of this research is to investigate memory reconsolidation as a fundamental mechanism of therapeutic change that bridges neuroscience and psychotherapy.
Materials and Methods: This study is a narrative review derived from a PhD dissertation in psychology, in which articles related to the keywords (Memory Reconsolidation, psychotherapy, and therapeutic change) were collected through searches in the reputable scientific databases PubMed, ScienceDirect, PsycINFO, Scopus, and the Google Scholar search engine, within the time frame of 1985-2024. In total, 48 articles related to the topic and objectives of the research were extracted from the full-text English language articles.
Results: Studies show that memory reconsolidation is a common mechanism of change among psychotherapy approaches, and through changes in memory structure, updating and modification of maladaptive memories, and ultimately cognitive-emotional reconstruction, it can cause lasting and profound changes in psychological problems and disorders.
Conclusion: The results showed that the convergence of neuroscience and psychotherapy through this mechanism is considered a new step in the development of more efficient treatment methods. Accordingly, focusing on memory reconsolidation in psychotherapy can significantly enhance the effectiveness of treatment and lead to profound and transformational changes in clients. Therefore, it is suggested that future research should focus on developing therapeutic models based on the mechanism of memory reconsolidation.

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