Showing 20 results for hasanvand
Shirin Hasanvand, Seyed Saeid Najafi, Mansore Forozy, Sakine Mohammad Alizade , Dr Ali Akbar Haghdoost,
Volume 12, Issue 3 (3-2011)
Abstract
High blood pressure is a disorder associated with stress. In numerous people, behavioral strategies or stress management interventions such as relaxation and massage are useful in control of their response to stress and consequently , the reduction of blood pressure. Regarding to more effects of combinational intervention therapy based on behavioral methods rather than application of pharmacotherapy , it is expected that the use of these methods including massage is more effective in decreasing blood pressure. Materials and Methods: In this quasi-experimental,based on pilot study, 90 hypertensive patients were chosen and their blood pressure and radial pulse were measured in 20 sessions during 5 weeks before and after back massage on Saturdays and Tuesdays and without massage on Sundays and Wednesdays . Data were collected by a demographic questionnaire and check list to record blood pressure and pulse, then these data were analyzed by STATA software. Results: The results showed that there was a decrease in the systolic and diastolic blood pressure and radial pulse by 6.3 and 3.9 mmHg and 2.9 beats per minute (p=0.0001). Conclusion: The results revealed that massage had decreasing effect on blood pressure and pulse of the primary hypertensive patients . Use of stress management interventions such as massage is an acceptable, simple and teachable method to families for better control of the disease.
Bahman Hasanvand, Farid Bahrami, Azam Darvishi, Kobra Karami, Masoud Chegeni,
Volume 13, Issue 1 (6-2011)
Abstract
Recognition of deformities and corrective exercise is a branch of physical education which intends to emend and treat various muscular weaknesses and deformities using proper and accurate corrective exercise and sports scientific principles.The aim of this study was to investigate the effect of regular corrective exercise on skeletal deformities such as scoliosis, shoulders dropping, flat foot and bow leg in secondary school male students of Khorramabad city as the statistical population.
Materials and Methods: 160 girls in khorramabad city, aged 12-14 years, participated in this study. The subjects were examined twice before and after 24 sessions of corrective exercise. Deformities were measured by grid plane, plumb line and other relevant tests. The gathered data were analyzed by descriptive statistical methods including: frequency, percentage and graphs.
Results: In 12 years old sbjects the degree of shoulders dropping, flat foot and bow leg in post- test were lower than pre-test and differences were significant (F=7.96, P<0.001& F=100.1, P<0.001 & F=27.63, P<0.001), but scoliosis was not significant (F=3.32 , P>0.001). The differences between pre and post measurments of shoulders dropping, flat foot and bow leg in 13 years old cases were significant (F= 100.1, P<0.001 & F=27.63, P<0.001 F=7.96, P<0.001),but for scoliosis, the differences were not significant (F=3.32 & P>0.001). Finally in 14 years old subjects for shoulders dropping, flat foot and bow leg, differences between pre and post- test were significant (F=7.96, P<0.001 & F= 100.1, P<0.001& F=27.63, P<0.001) but scoliosis were not significant(F=3.32 , P>0.001).
Conclusion: The findings of this study emphasize the reliable, accurate, feasible, and easy methods for decreasing abnormalities. Furthermore, it showed that the corrective exercise programs, can reduce the abnormalities in oldness.
Bahman Hasanvand, Kobra Karami, Abdollah Khodadi, Mehdi Valipour,
Volume 13, Issue 3 (12-2011)
Abstract
Background : This study determined the impact of strength and resistance training on hemoglobin Glycoside and glucose in type II diabetic patients in Khorramabad in 2009.
Materials and Methods: This quasi-experimental study was carried out on 30 men with type 2 diabetes referred to laboratories in Khorramabad, selected by screening and interview and purposeful sampling . After the subjects completed questionnaires of medical records and written consent, they were randomly divided into three groups: endurance training, strength and control groups. Conditions for participants were: over 30 years of age, blood sugar 150-250, the absence of any other chronic disease and history of sports last three months, stroke, hypertension, diabetes and severe complications . Before training, the subjects were fasting for 8-12 hours and then blood sampling was performed. Strength training and endurance for 8 weeks under coach concerned were applied. Strength training includes 10 motions for muscles and for each move three to four sets and sets of 10 to 12 repeats were considered and the principle of overload followed during the eight weeks . Endurance exercise was running on a treadmill machine with a maximum heart rate 60%. Ten subjects in the control group followed and performed the recommendations till end of the study. After the eight-week training period, post test (blood test) done. Data were analyzed using SPSS statistical software.T pairs was used to compare means(Pre test, Post test).
Results: 29 subjects in three groups of exercises were conducted until the end. Average age, weight, BMI and the amount of drug in the three groups showed no significant difference statistically (p=0/76). Reduction in glaciated hemoglobin before and after the endurance test, showed significant differences (p =0/02 ).
Conclusion: This study shows that endurance training reduces Glycoside hemoglobin levels, the amount of strength training, although it did not significantly reduce, the strength training appears to cause more significant changes.
Kobra Karami , Katayon Bakhtiar , Bahman Hasanvand , Shirzad Safary , Shirin Hasanvand ,
Volume 14, Issue 4 (12-2012)
Abstract
Background : The aim of this study is to compare the quality of life and public health after natural and cesarean delivery in women referred to Khorramabad health centers in 2009-2011.
Materials and Methods: In this cohort study all pregnant women referred to health centers in Khorramabad were studied. 380 persons participated in the study selected using purposive sampling method. Data collection was done in 18 months. The information was collected in steps (a): the last month of pregnancy and (b):eight weeks after delivery.GHQ questionnaire was used in order for primary assessing, its validity confirmed by the World Health Organization. Data were analyzed using logistic regression, chi square test, Mann-Whitney at 5% significance level with SPSS software, version 16.
Results: 250 subjects out of 380(146 natural deliveries and 104 cesarians) filled out interview forms and questionnaires. The results show that there are statistically significant differences between physical domain scores (P = 0.001) and mental scores (P = 0.02)which show significant differences in quality of life and in environment and social areas and total, no statistically significant difference was observed. Chance of causing disease symptoms in women with cesarean delivery in the scale of physical complaints was 09.3 times (P = 0.001), depression 75.1 times (P = 0.02) and impaired social interaction 68.1 times (P = 0.04) greater than women with vaginal delivery, all of which are significant at the 5% level of statistical error.
Conclusion:Quality of life in its various aspects and general health in mothers with normal delivery, better grades and better shows.
Asghar Kianzadeh , Maghsood Peeri , Mohammad Ali Azarbayjani , Bahman Hasanvand , Farid Bahrami , Hosein Omidi ,
Volume 15, Issue 1 (5-2013)
Abstract
Background: The study on the influence of different protocol of resistance training on left ventricular of adolescent boys dose have its limitation. The aim of this study was to determine the influence of low-intensity resistance training versus high-intensity resistance training on left ventricular structure and function of healthy adolescent boys by echocardiography.
Materials and Methods: Twenty-four subjects volunteers, 15 to 18 years old were randomly assigned to three groups in the eight-member low-intensity resistance training (40% to 60% maximum strength), high-intensity resistance training (70% to 90% maximum strength) and control group. Protocol training was conducted 8 weeks, 3 sessions. Variables were measured using one and two-dimensional echocardiography at rest and special formulas.
Results: In the post-test to pre-test, in low-intensity resistance training group means values, left ventricular posterior wall thickness at end-systole (P=0.028) and resting heart rate (P=0.017) showed significant increase and decrease respectively. In post-test, it was shown a significant increase means values left ventricular posterior wall thickness at end-systole and left ventricular mass index in low-intensity resistance training group than high-intensity resistance training group (P=0.007 and P=0.005 respectively) and control group (P=0.005 and P=0.0015 respectively) and mean value left ventricular mass in low-intensity resistance training group than high-intensity resistance training group (P<0.007).
Conclusion: Low-intensity resistance training than high-intensity resistance training in healthy adolescent boys caused some changes in left ventricular structure and function, probably these changes were associated with increased volume and pressure load.
Phd Student in Educational Psychology Saba Hasanvandi , Phd Student in Educational Psychology Samira Saleh Ardestani, Sherin Ghazi, Bagher Hasanvand , Fereshteh Yadi,
Volume 18, Issue 4 (3-2017)
Abstract
Background: The aim of present study was to investigate executive functions included of working memory, organization-planning and reasoning in the children with and without specific learning disability with the characteristic reading and writing.
Materials and methods: The design of this research was Ex-Post Facto design. Statistical population was all male students of third grade primary schools in Tehran which were referred to education institution with diagnosis special learning disorders in educational centers. The sample included of 90 students chosen and assigned into 3 groups of 30 students, included of: children who had specific learning disability with characteristic reading, children who had specific learning disability with characteristic writing, normal children were selected by systematic randomized sampling and 3 groups were compared. The data instruments were: Wechsler’ subtests of similarities and digit differences, Andre Ray test, in formal (unofficial) reading and dictation test. The obtained data were analyzed with ANOVA.
Results: The results showed that there was difference between the group of normal children and other group in executive functions including working memory, organization-planning and reasoning (P<0.05). Also there was difference between two children groups with specific learning disability with characteristic reading and writing in working memory and reasoning, whereas for organization-planning parameter there were not seen any differences between these two groups (P<0.05).
Conclusion: Regarding to obtained results, it is recommended to adoption some ways for improvements of working memory, organization-planning and reasoning
Saba Hasanvandi, Shirin Ghazi, Ezato Lah Ghadampour,
Volume 19, Issue 2 (10-2017)
Abstract
Background: The present study was to evaluate effectiveness of positive therapeutic program on psychological well-being in women with ADHD children.
Materials and Methods: This study was quasi-experimental and pretest-posttest with control group kind. The study sample consisted of 50 mothers in 2015-2016. Convenience sampling was applied to select the participants. Participants were quite randomly divided into two groups of 25 individuals. These groups were randomly divided into two groups of experimental and control groups. The experimental group received positive program and the control group received no intervention. The therapeutic packages of the positive were conducted for six sessions. Before and after the experiment all of the participants responded to the psychological well-being questionnaire. Three months after the experiment, i.e. the follow-up stage, in order to check storage of the program's effects, the participants answered the instrument. The data were analyzed by covariance (MANCOVA) test using SPSS 18.0.
Results: The results of this study showed that positive program resulted significant effect in all of six components of psychological well-being. It should be noted that all of the results were significant at (p< 0.05) (DF 48, 2) and its effect maintain three months after the experiment (p< 0.05).
Conclusion: Regarding to results, the positive therapeutic program can be effective in decreasing psychological problems. Also, this program is useful in promoting mental health among mothers with psychological problems such as ADHD.
Shirin Ghazi, Saba Hasanvandi, Ezato Lah Ghadampour,
Volume 19, Issue 4 (10-2017)
Abstract
Background : The aim of this study was to predict the test anxiety and academic self-handicapping based on alexithymia in students with reading learning disorder.
Materials and Methods: This study is a correlational study. The population included all of students with reading disorder in Khorramabad city in 2015-2016. Cohen’s Proposed Method was used for determining the size of the sample,and among the students who referred to education center in Kohrramabad, based on specialist's diagnosis in this field, in sum 112 students carried criteria for participating in this study. The students completed the test anxiety, self handicapping and alexithymia questionnaires. Regression analysis was used for analyzing data. The data were analyzed by statistical SPSS software version 18.
Results: The results showed that the correlation between study variables were significant (p>0.001). Also, The results of regression analysis showed that alexithymia was able to predict ( 54/. P<0.001) the total variance of test anxiety and academic self-handicapping.
Conclusion: The results can help to counsolers and workers in the education field for effective interventions in test anxiety and academic self-handicapping.
Bahman Hasanvand, Rahman Soori, Sirous Choobine, Ali Akbarnejed,
Volume 19, Issue 4 (10-2017)
Abstract
Background: This study aimed to investigate the effect of eight weeks of interval training on gene expression of liver X receptors (LXR) in Wistar male rats.
Materials and Methods: In this study, 24 male wistar rats (200-250 g) were randomly used to three groups for this purpose, 24 male Wistar rats were prepared and divided into three groups: control (8 = n), high intensity intermittent exercise (8 = n) and continuous submaximal exercise (8 = n), respectively. The treadmill exercise program was performed for eight weeks, three days a week for 40 minutes. High intense exercise protocol, 30 minutes running periodic (every period of four minutes and two minutes running with 90-85% of VO2 max intensity active recovery with 60-50% of VO2 max) three days a week for eight weeks. Also, the continuous training group under maximum was an exercise intensity equivalent to 50 to 55 percent of maximum oxygen consumption of the mice.
Results: The results showed that there was a significant difference between the four groups in the gene expression level, after data analysis and test research hypotheses, findings of this study show that the expression of LXR alpha gene, apolipoprotein 1, ABCG1 a significant increase in intensity interval exercise than the control group (p = 0.004). The results also showed a significant difference between the three groups in the expression of LXR beta and apolipoprotein 2, SR-BI does not exist. Although the results showed a slight increase in groups of periodic training and continuing slight increase, but this has not led to a significant difference.
Conclusion: Overall results indicated the superiority of intense interval training than submaximal exercise in reverse cholesterol transport is continuous. Intense interval training by increasing hepatic expression of the receptor gene as well as the main cause of the liver and eventually out HDL receptors can play an important role in reducing cardiovascular diseases such as atherosclerosis.
Farzane Hasanvandi, Ali Ashraf Jafari, Shahla Ahmadi,
Volume 19, Issue 5 (2-2018)
Abstract
Background: In order to study of dry matter yield and essential oil efficiency in8 accession of three species Saturja in agricultural research station of Khorramabad, the experiment was carried out during 2010.
Materials and Methods: Seeds of the accession were sown in pots and transferred to field in 14-16 leaves stage seedling. The spaced plants were cultivated in randomized complete blocks with three replications. For measurement of essential oil efficiency, in the flowering stage, the foliages were harvested and dried. The essential oil was extracted by vapor method distillation. The essential oil production was calculated by dry matter yield x oil%. The data were collected and analyzed for yield and morphological traits. The means of treatments were compared by DMRT method.
Results: The results showed significant that differences between species and accession within species for all of the traits except plant surviving rate (P<0.01). The species of S.mutica had higher values than means of two other species.
Conclusion: Results obtained in this study showed that dry matter yield and oil content of S.mutica is more than S.Khuzestanica and S.rechingeri. This species was proposed as a suitable species for domestication and cultivation in Khorramabad region.
Ali Hasanvand, Ali Falahati , Kiomars Soheili,
Volume 20, Issue 2 (6-2018)
Abstract
Background : Most economic theories are based on the belief that decentralization of public expenditure will lead to an increase in provincial benefits and a consequent improvement in economic and social indexes. The purpose of this study is to analyze the effect of financial decentralization on the health sector in Iran.
Materials and Methods: In this applied research, the topic was reviewed by the panel vector self-regression model, using data from 31 provinces of Iran in the period of 2001-2015, with a sample size of 3720 observations.
Results: The results show that financial decentralization, on the basis of indexes reviewed in this study, has a positive causality relation with the number of active hospital beds and the level of public sanitation from gross domestic product. Regarding to the results of variance analysis, it can be acknowledged that the changes in the areas of health and sanitation usually resulted from changes in financial decentralization and the resources allocated to sanitation, which explain the fluctuations of 1.58 and 0.48 percent. The results of reviewing the immediate response functions also indicate the positive effects of funding decentralization shocks on the index rate in the health area.
Conclusion: Financial decentralization and proper distribution of central government health funds to the provinces, can improve the level of public health in the whole country, by increasing provincial sanitary resources, and in addition, promoting health and sanitation indexes.
Soheila Hasanvand, Mohammad-Hasan Imani-Nasab, Mehdi Birjandi, Roudbeh Omidifar, Jamil Sadegifar,
Volume 21, Issue 3 (11-2019)
Abstract
Background: The age pyramid of our country is being reversed. Planning for the provision of healthcare services for the elderly requires the investigation of the factors affecting their utilization of health services. The aim of this study was to determine the availability of hearth services for the elderly at Lorestan province and the relationship between their utilization of these services with socioeconomic variables.
Materials and Methods: This cross-sectional study was conducted in 2017. The study population included the elderly discharged from the hospitals affiliated to Lorestan University of Medical Sciences in 2017. The data of 428 patients were collected during phone interviews. The collected data were analysed by SPSS-18 software and chi-square test, Mann-Whitney test, Spearman test, and independent t-test.
Results: The rates of the utilization of medical and paramedical services in at least one occasion during the last three months among the studied elderly were 25.5% and 27.7%, respectivly. Utilization of health services was significantly affected by family structure, literacy status, residence of the patient (town or village), social origin (the residence until the age of 18), unemployment status, number of children, type of insurance, complementary insurance, having a chronic desease, self-evaluation of health status, satisfaction of the status quo, income, employment status, house ownership, and having a private room. However, there were not significant relationships between the elderly’s utilization of different health services and their gender, marital status, children’s location, and car ownership.
Conclusion: Elderly people utilize different health services more than the general population. Considering the significant relationship between certain socioeconomic variables and the utilization of health services among the elderly, it is recommended that planning for the provision of health services to them should be based on the investigation of their utilization of health services and their determinants.
Mojtaba Khaksarian, Saba Hasanvandi, Roghayeh Piri, Mohammad Mahdi Sohrabifard,
Volume 22, Issue 1 (4-2020)
Abstract
Background: Nowadays, neurofeedback is used as a new method to improve the symptoms of ADHD and epilepsy. The effectiveness of this new therapeutic approach in various disorders has been investigated. The purpose of this study was to compare the efficacy of this treatment in patients with hyperactivity and epilepsy.
Materials and Methods: This study was quasi-experimental with pretest and post test and the control group. The study population comprised all the children with ADHD and epilepsy in Karaj. The sample consisted of 60 infected children (15 indivuduals suffering from ADHD, 15 people with epilepsy and 30 controls) who were selected by the random sampling method. In the pre-test, the behavioral behavior (executive summary) for children was completed. This tool reflects the teacher's view of student behaviors in the field of executive functions. In fact, it provides a tool for screening the performance problems. Executable executive functions in this log include inhibition, flexibility, emotional control, initiation, work memory, planning / organizing, inventory management and monitoring. To conduct the research, the beta / theta program was used for all the subjects. The aim was to increase theta waves and decrease beta waves. After completing 10 sessions (5 weeks and 2 sessions per week), the neurofeedback was run and the log was re-entered. Descriptive statistics (mean and standard deviation) were used to analyze the data and the one-variable covariance method was used to infer the data. Spss version 18 was used to analyze the data.
Results: The findings of the research indicated that the performance scores in the pre-test and post-test of the studied groups were significantly different )P<0.001(. Moreover, the effect of neurofeedback treatment on the improvement of executive functions in the ADHD group was higher than the epileptic and control groups )P<0.001(.
Conclusion: Based on the findings, neurofeedback is efficient but its effect is different in patients with ADHD and epilepsy. Hence, the use of neurofeedback is more effective in improving the performance of ADHD patients. These results can be useful in the field of overactive treatment using novel methods.
Bahman Hasanvand, Yaghoub Mehrialvar, Ali Heydarianpour, Fahimeh Erfaniadab,
Volume 22, Issue 2 (8-2020)
Abstract
Background: The aim of this study was to compare the intensity of exercise with saffron supplementation on metabolic balance in overweight and obesity women.
Materials and Methods: Among obese and overweight women, 42 obese women with body mass index above 25 were selected by purposeful and accessible randomized to six groups of high intensity training, continuous exercise, control, high intensity training with saffron supplement, continuous training with saffron supplement and saffron supplement group. After the initial sampling, the intervention groups were active for 12 weeks. All data analysis was performed at the significant level P≤0.05.
Results: There was a significant difference in weight, body mass index and fat percentage between control groups, training interventions and saffron (P=0.001). There was a significant difference in the visfatin between all groups with intermittent exercise and saffron group (P≤0.05). The results also showed that there was a significant difference in this variable between saffron, endurance training and control group. There was a significant difference in the Irisin variable between the intermittent exercise group and saffron, endurance and saffron and endurance training with control group (P≤0.05). In the ghrelin variable, there was only a significant difference between the saffron and intermittent exercise groups with all groups (P≤0.05). The other groups did not show significant differences.
Conclusion: According to these results, intense intermittent exercise with saffron supplement is appropriate strategy for health and obesity prevention. Of course, more research is needed in the future to reach a definitive conclusion.
Ali Hasanvand, Mohsen Arefnezhad, Asma Soleimani,
Volume 23, Issue 3 (8-2021)
Abstract
Background: The countries should be economically developed in today’s world. By reviewing the literature, a healthy and efficient workforce is a key factor in economic development, which indicates the effectiveness of the health sector in countries. Efficient information systems should be used to achieve efficiency, effectiveness, productivity, service quality, and customer satisfaction. The present study aimed to identify and prioritize the factors affecting the efficiency of hospital information systems.
Materials and Methods: Interviews and questionnaires are collaboratively used in this study to identify the factors affecting the productivity of hospital information systems. A total of 22 hospital information systems specialists (IT and system support experts) were selected based on the purposive sampling method. In the present study, experts' views on the factors affecting the productivity of hospital information systems were first identified using a survey research method. The factors are prioritized from the questionnaires and the Fuzzy Delphi method.
Results: After analyzing the findings, it was found that physicians' satisfaction, information quality, usability, appropriate support, high reporting ability, being on the web, and proper user training are the factors affecting the efficiency of hospital information systems.
Conclusion: As a result, considering the findings of this study during the implementation of information systems projects, hospital officials can play a significant role in economically improving public health.
Abolfazle Abbaszadeh, Farshid Torkzaban, Mahmood Reza Morad Khani, Setayesh Farhadi, Amin Hasanvand,
Volume 24, Issue 1 (4-2022)
Abstract
Background: Neuropathic pain is one of the most important consequences of nerve damage, manifesting itself as various demonstrations, including hyperalgesia and allodynia. The present study aimed to investigate the effect of concomitant use of Epalrestat and Sitagliptin on pain reduction in the chronic constriction injury (CCI) model in rats through anti-inflammatory and antioxidant effects.
Materials and Methods: The present study was conducted on a total of 50 male rats that were randomly assigned to five groups: sham, CCI, CCI+Epalrestat(100 mg/kg, IP injection, for 14 days), CCI+Sitagliptin(10 mg/kg, IP injection, for 14 days), and CCI+Epalrestat(100 mg/kg)+Sitagliptin(10 mg/kg). Rats underwent behavioral tests on days 4, 7, and 14 after the surgery. After 14 days, the spinal cord was collected to measure anti-inflammatory and antioxidant tissue concentrations.
Results: The results of this study demonstrated that simultaneous injection of these two drugs in group 5 had the most neuroprotective effect, compared to that in groups 3 and 4. The results of dynamic responses to mechanical stimulation on the 14th day illustrated that there was no significant difference in groups 3 and 4 . Nonetheless, in Group 5, a significant difference was detected in all factors. The results pointed out that the combined use of Epalrestat and Sitagliptin decreased the levels of Tumor necrosis factor, Interleukin 6, and MDA, and also increased the level of glutathione peroxidase
Conclusion: As evidenced by the obtained results, the concomitant use of Epalrestat and Sitagliptin can be considered effective and safe for the treatment of neuropathic pain with strong inhibition of inflammatory factors and oxidative stress.
Meysam Behzadifar, Hanieh Hasanvandi, Saeed Shahabi, Ahad Bakhtiari, Samad Azari, Seyed Jafar Ehsanzadeh, Masoud Behzadifar,
Volume 24, Issue 4 (3-2023)
Abstract
Background: Physiological childbirth refers to the natural birthing process that does not involve medical or pharmaceutical interventions. This method is characterized by spontaneous labor, the absence of medical interventions, freedom of movement, and active participation of the mother. Rate of cesarean delivery has been increasing over the past decade in Iran, accounting for approximately 50% of all births in the country as Iranian healthcare officials have also promoted physiological childbirth. In this regard, it is important to recognize that physiological birth is a personal choice; therefore, women should receive the necessary information and support to make informed decisions about their birth experiences. Besides, it is critical to provide the necessary education for healthcare providers and engage with women to address their cultural and social beliefs about childbirth. Additionally, the supportive policies of the government that promote physiological childbirth and educational programs can also be valuable in this regard.
Saeed Daraie, Shirin Hasanvand, Fateme Goudarzi,
Volume 25, Issue 2 (8-2023)
Abstract
Background: The unstable condition of tracheostomy patients and the lack of support resources for patients and their families during discharge is the biggest challenge, especially for their home and non-professional caregivers. The present study aimed to identify the factors affecting the care of tracheostomy patients provided by home caregivers.
Materials and Methods: This qualitative research was conducted from September 2018 to December 2019 using the content analysis method and interviews with nine home caregivers and one professional caregiver in Lorestan Province, Iran. The required data were collected by holding in-depth semi-structured interviews and continued until reaching data saturation. Simultaneously, the gathered data were analyzed using the 5-step approach of Graneheim and Lundman (2004).
Results: The results led to the extraction of 2 themes of preventing and facilitating care factors, 7 categories, and 21 subcategories. The categories related to the theme (preventing factors) of patient care challenges included neglecting the caring role of informal caregivers by the healthcare system, interaction challenges, the high pressure of caregiving, and lack of trust. The categories related to the facilitating factors theme were the experience of the care facilitating over time, the intensification of care with the aim of prevention, and hope and inner satisfaction underlying the care.
Conclusion: The challenges of the family's lack of readiness to accept the new role, the exhausting nature of caregiving, and the caregivers’ lack of skills, and as a result, the imposition of a burden of caregiving, and the emergence of harmful consequences for them in various dimensions, the existence of non-governmental organizations that aim to continue to care for these patients and support their families seems necessary. With support systems and gaining experience over time, the care transition process is facilitated.
Amin Hasanvand, Arefeh Ghiasvand, Mohammadjavad Nourmohammadi, Fatemeh Hatami, Zahra Haghighatian, Yaser Mokhayeri, Mojtaba Khaksarian,
Volume 26, Issue 3 (10-2024)
Abstract
Background: Neuropathic pain is one of the most important chronic and pathological problems that can cause disruptions in human life. Some studies indicated that the release of inflammatory cytokines and increased oxidative activity can increase nerve damage. Adalimumab is a human anti-monoclonal drug that can cause therapeutic effects in different diseases. The present study aimed to investigate the analgesic effects of adalimumab in the chronic constriction injury (CCI) experimental pain model in rats.
Materials and Methods: A total of 20 male Wistar rats were utilized in this study and were randomly assigned to four groups: the first group served as the control, the second group underwent CCI, the third group received CCI in conjunction with adalimumab (5 mg/kg), and the fourth group received CCI with adalimumab (10 mg/kg). Behavioral assessments were conducted 4, 7, and 14 days post-CCI induction. The spinal cords were extracted after these assessments, and the supernatants were analyzed for inflammatory and oxidative enzymes. Data analysis was performed using Prism GraphPad statistical software.
Results: The analysis of the obtained data indicated that the injection of adalimumab in the third and fourth groups decreased the activity of inflammatory cytokines, such as TNF-α, IL-6, and CRP. In addition, it decreased the activity of MDA and increased the SOD and CAT enzymes. Moreover, adalimumab significantly improved the outcomes of thermal allodynia, mechanical allodynia, and thermal hyperalgesia in the CCI rats treated with this medication.
Conclusion: The administration of adalimumab can be used to treat or reduce neuropathic pain with its anti-inflammatory and antioxidant activity, along with neuroprotective effects.
Fatemeh Shiravand, Saba Hasanvand, Abolfazl Jabbar Pour, Mahboube Sahl Abadi, Mojtaba Khaksarian,
Volume 26, Issue 3 (10-2024)
Abstract
Background: Neurodegenerative diseases are a group of disorders caused by the destruction and death of neurons. They are clinically heterogeneous and can manifest in a variety of ways. Evidence suggests that inflammation plays a major role in the pathogenesis of several common neurological diseases, including Alzheimer's disease, Parkinson's disease, multiple sclerosis, and common psychiatric disorders, such as depression, bipolar disorder, and obsessive-compulsive disorder. One of the effective and novel interventions is transcranial direct current stimulation (tDCS), which modulates central nervous system activity. This non-invasive brain stimulation method induces changes in inflammatory responses.
The present study aimed to assess e the effects of tDCS on neurodegenerative diseases caused by neuroinflammation. Despite the prominent role of inflammation in the development of neurodegenerative diseases, there is still no effective and safe treatment to control inflammatory processes in these diseases. On the other hand, considering that some inflammatory processes in the nervous system are beneficial, controlling inflammation rather than suppressing it is a more effective treatment approach. It seems that tDCS induction can be a safe and effective method for the relative improvement of some symptoms of neurological and psychiatric diseases.
