Showing 7 results for Aging
Farmarz Karimian, Maryam Mansouri- Pour,
Volume 5, Issue 2 (1-2004)
Abstract
Introduction: Diagnosis and localization of offending glands in hyperparathyroid patients is a subject that has always concerned surgeons.
Until two decades ago this could only be achieved through complete neck exploration by the surgeon.
In recent decades, with introduction of better imaging techniques such as advanced sonography and isotopic scans, remarkable progress has been made in this field. To evaluate these techniques a study was designed and performed.
Materials and Methods: This is a retrospective descriptive study in a group of patients with primary hyperparathyroidism who underwent parathyroidectomy in Imam Khomeini General hospital and Dr. Shariati General hospital, Tehran university of medical sciences, during the years 1989 to 1998.
The purpose of this study is to evaluate the sensitivity and accuracy of the available imaging facilities in diagnosis and localization of the offending gland(s), compared to intraoperative findings.
Findings: 61 patients were studied. 11 men (18%) and 50 women (82%) 47 single adenoma (77%), 2 multiple adenoma (3%) and 12 hyperplasias (20%) were reported. 24 patients with single adenoma had MIbI scan with a sensitivity and accuracy of 70% and 100%, respectively. In all cases of multiple adenoma and hyperplasia who had MIbI scan, the results was false negative. Sensitivity of Th-Tc scan for single sadenoma was 33.3%. Sonography had a sensitivity of 71.5% for adenoma and 40% for hyperplasa with 100% accuracy for both of them. Sensitivity and accuracy of intraoperative diagnosis and localization for adenoma was 100% and 96.7%, respectively. For hyperplasia these figures were 83.3% sensitivity and 100% accuracy.
Conclusion: According to the results in diagnosis and localization of offending gland(s) in primary hyperparathyroidism, intraoperative judgment of experienced surgeon has a higher sensitivity and accuracy than available imaging facilities. This is specially true for multiple adenoma and hyperplasia. Therefore, we suggest that still during surgery for hyperparathyroidism all parathyroid glands should be explored, and limited dissection directed by imaging findings should be avoided. However, with increasing experience and introduction of new technologies such as radiotracing, one may expect better results from imaging day by day.
Maryam Yasrebirad, Parichehr Khedri , Mansoure Foruzi , Majid Maleki ,
Volume 14, Issue 3 (9-2012)
Abstract
Background : The function of the coronary arteries is to transport oxygenated blood to the heart muscle and if these arteries have been clogged due to fat plaque, patient has to undergo coronary angiography to determine the narrowing rate of coronary arteries and for this purpose, the left femoral artery is used . The aim of this research is to study the effect of pressure bandaging in reducing bleeding , bruising, back pain and groin pain in the patients undergoing coronary angiography.
Materials and Methods: This quasi-experimental study was carried out on 100 patients undergoing coronary angiography in surgical and CCUwards of Shahid Rajaee hospital of Tehran and Khorramabad Shahid Madani hospital. Subjects were randomized to receive a pressure bandage(no=50) or sand bag(no=50) after manual compression of the femoral artery puncture site.
Results: The patients without pressure bandages had a higher incidence of bleeding and bled earlier(p<0/05) after catheter removal than the patients with bandages. The incidence and extent of bruising was the same in both groups of patients with sandbags experienced a higher incidence of back and groin pain .
Conclusion: Thus, regarding the associated increase in patients, comfort, and delay in time of onset of bleeding, pressure bandages could be used routinely in the management of patients after coronary angiography.
Hosain Hosseini, Bahram Abedi, Hoseyn Fatolahi,
Volume 21, Issue 1 (5-2019)
Abstract
Background: A reduction in physical activity levels in the elderly causes diseases. Weight bearing is one of the problems of exercising in the elderly. The purpose of this study was to investigate the effect of water-based training period on adropin levels, insulin resistance, and lipid profiles in elderly men.
Materials and Methods: Twenty elderly men (69.5±3.62) were divided randomly into two groups of aerobic aquatic training and control (n=10). The training group participated in 8 weeks of training in water. Before and after intervention, blood sampling was performed to measure the serum levels of adropin, glucose, insulin, triglyceride, total cholesterol, LDL, HDL, and insulin resistance. To analyze the data, a mixed analysis of variance was used.
Results: Weight (P=0.002), BMI (P=0.002), insulin (P=0.001), glucose (P=0.008), insulin resistance (P=0.001), triglyceride (P=0.001), total cholesterol (P=0.001), LDL (P=0.015), adropin (P=0.001) and HDL (P=0.001) in the training group showed a significant improvement compared to the control group.
Conclusion: It is possible that aerobic water-based exercise decreases insulin resistance and improves lipid profiles in older men, leading to improved diabetes markers. It seems that adropin plays a role in this regard. Therefore, one of the most effective methods for preventing, controlling or improving diseases, especially metabolic syndrome in older people, is probably the use of water-based exercises. Especially given that these exercises reduce the problem of weight bearing in the elderly.
Saeid Kouhgardzadeh, Vahid Valipour Dehnou, Mahdieh Molanouri Shamsi,
Volume 23, Issue 4 (9-2021)
Abstract
Background: High-intensity functional training can be well performed by the elderly; however, the effect of this training on brain-health-related factors has not been studied yet. Therefore, this study aimed to investigate the effect of eight weeks of high-intensity functional training on serum levels of BDNF, IGF-1, and VEGF in elderly men and women.
Materials and Methods: This quasi-experimental study included 23 subjects (7 males and 16 females) who were divided into experimental (n=16) and control groups (n=7). The experimental group performed a training protocol consisting of six exercises in three sessions (each session was 25 min) per week for eight weeks. The exercises were performed at all-out intensity for 30 sec. There was a 15-sec rest between each set and a two-min rest between each exercise. Paired samples t-test and ANCOVA were used to analyze the data, and a p-value less than 0.05 was considered statistically significant.
Results: The results showed that the serum levels of BDNF (P=0.0005, +11.37), VEGF (P=0.0005, +7.49), IGF-1 (P=0.001, +3.91), LDL (P=0.004, -3.33), and HDL (P=0.004, +7.48) changed significantly in the experimental group. On the other hand, in the control group, serum levels of BDNF (P=0.149, +1.58), IGF-1 (P=0.486, +0.27), LDL (P=0.897, +0.14), and HDL (P=0.534, +1.10) had no significant changes; however, VEGF (P=0.01, +0.67) significantly changed. The results of ANCOVA showed a significant difference between the two groups regarding all variables (P<0.05).
Conclusion: Eight weeks of high-intensity functional training in elderly men and women increases the serum levels of brain health-related factors. Therefore, functional training is recommended to improve brain function in the elderly.
Mohsen Farhadiyani Asgarabadi, Nasser Behpoor, Ahmad Mohammadi Moghaddam,
Volume 24, Issue 1 (4-2022)
Abstract
Background: Considering the importance of maintaining and promoting the health of the elderly, it is necessary to examine their hormonal responses during physical fitness exercises. This study aimed to investigate the effect of two combined training methods with and without blood flow restriction on some physical fitness (muscle strength and muscle endurance), anabolic (testosterone), and catabolic (cortisol) factors.
Materials and Methods: The present research was quasi-experimental with a pretest-posttest design. A total of 24 elderly men with no history of training participated in this study voluntarily. They were divided randomly into two experimental groups and one control group. Measurement included the 30-second sit-up test, the sit-up test with 50% of one-repetition maximum (to the point of fatigue), testosterone level, and cortisol level. In the group with blood flow restriction, both upper thighs were closed with cuffs and the exercise was performed with the intensity of 20-30% of 1RM, to the point of fatigue. In the training group without restriction, the same movements were performed with an intensity of 65- 80% of 1RM, to the point of fatigue. The covariance test and Bonferroni post hoc test were used to analyze the data.
Results: The results showed that training with blood flow restriction had a significant effect on increasing muscle strength and muscle endurance similar to that caused by high-intensity training without blood flow restriction. Moreover, the results of the study on the effect of exercise with and without vascular occlusion on testosterone and cortisol levels showed that both training methods had similar effects on increasing testosterone levels and decreasing serum cortisol levels in older men.
Conclusion: Since heavy weight training is difficult and risky for the elderly, they can effectively practice low-intensity resistance exercises with blood flow restriction. Eventually, the study of other hormonal and neuromuscular mechanisms involved in the effectiveness of these exercises will expand knowledge in this field of study.
Bagher Soheili, Syed Ali Hoseini, Ahmad Hematfar,
Volume 25, Issue 2 (8-2023)
Abstract
Background: Aging can lead to a decrease in cardiac function and an increase in oxidative stress in the heart, which leads to cellular aging through mitochondrial dysfunction. The present study aimed to investigate the antioxidant effects of high-intensity interval training (HIIT) and genistein (Ge) consumption in the heart tissue of elderly rats.
Materials and Methods: In this experimental study, 30 female Sprague-Dawley rats aged 18 to 24 months were selected and divided into five groups of six rats, including 1) HIIT, 2) Ge, 3) HIIT + Ge, 4) control, and 5) sham. During eight weeks, groups 2 and 3 received 60 mg of Ge dissolved in DMSO per kilogram of body weight daily, and group 5 received 60 mg of DMSO per kilogram of body weight per day intra-peritoneally. In addition, groups 1 and 3 ran on the treadmill three times per week. For statistical analysis of data, Shapiro-Wilk, independent samples t-test, one-way ANOVA, and Tukey's post-hoc test were used.
Results: High-intensity interval training had a significant effect on increasing GPx and MDA (P<0.05), Ge led to a significant decrease in SOD (P<0.05); however, HIIT with Ge had not interactive effects on improving SOD, GPx, and MDA (P<0.05).
Conclusion: It seems that the antioxidant system is dependent on the intensity of exercise and the dose of genistein. Therefore, HIIT and Ge in this study have no interactive effect on the oxidant-antioxidant system in the heart of elderly rats.
Sona Zare, Rahim Ahmadi, Mohammad Soroush Ansari, Elahe Aliheydari,
Volume 26, Issue 4 (10-2024)
Abstract
Background: Many studies have shown that vascular stromal cell injection can lead to skin repair; however, there is limited information about the effects of vascular stromal cell injection on the improvement of peri-ocular aging. Based on this, the present study investigated the effects of vascular stromal cell injection of autologous adipose tissue on the treatment of aging around the eyes.
Materials and Methods: In this clinical trial, cells were injected subcutaneously into middle-aged people with aging around the eyes. Data were analyzed in SPSS 25 software using t-test and ANOVA.
Results: The results of this study indicated that the injection of vascular stromal cells significantly reduced the volume and area of wrinkles around the eyes (P<0.05). Furthermore, individuals aged 44 and 45 showed the greatest improvement in signs of eye aging compared to other age groups.
Conclusion: In conclusion, it can be stated that the injection of vascular stromal cells has a significant impact on the repair and improvement of aging signs in the periocular area. This method also shows the potential to become an effective clinical and therapeutic approach for skin rejuvenation and the reduction of wrinkles around the eyes.
