Showing 3 results for Coenzyme Q10
Hasan Ahmadvand , Ali Khosrowbeigi , Shahrokh Bagheri , Reza Haji Hosseini , Farshid Ghazanfari , Leila Nemati ,
Volume 11, Issue 4 (2-2010)
Abstract
Oxidation of low-density lipoprotein (LDL) has been strongly suggested as a key factor in the pathogenesis of atherosclerosis. Thus the inclusion of some anti-oxidant compounds such as Satureja Khozistanica,vitamin E and coenzyme Q10 in daily dietary food stuff may inhibit the production of oxidized LDL and may decrease both the development and the progression of atherosclerosis. The present study investigated the inhibitory effects of Satureja Khozistanica, vitamin E and coenzyme Q10 on LDL peroxidation induced by CuSO4 quantitatively in vitro. Materials and Methods: LDL was incubated with CuSO4 and the formation of conjugated dienes and thiobarbituric acid reactive substances (TBARS) of LDL were monitored as markers of LDL oxidation. Inhibition of this Cu-induced oxidation was studied in the presence of extracts of Satureja Khozistanica,vitamin E and coenzyme Q10. Results: It was demonstrated that Satureja Khozistanica like vitamin E and coenzyme Q10 is able to inhibit LDL oxidation and decrease the resistance of LDL against oxidation in vitro. Conclusion: This study showed that Satureja Khozistanica similar to vitamin E and coenzyme Q10 prevented the oxidation of LDL in vitro and it may suggest that they have the similar effect in vivo
Dr Hasan Ahmadvand, Dr Majid Tavafi, Dr Gholamreza Shahsavari, Dr Ali Khosrowbeygi, Foad Abdolahpour , Shahrokh Bagheri, Leila Nemati,
Volume 13, Issue 1 (6-2011)
Abstract
The prevalence of diabets in the world is rapidly rising. Currently over 180 million persons worldwide have diabets and this number is expected to be doubled in the year 2030. In diabets stress oxidative markrs are increased. Coenzyme Q10 as a potent antioxidant can decrease lipid peroxidation and deplete free radicals. The persent study investigated the effects of coenzyme Q10 on serum lipid profile in male Wistar rats diabetics quantitatively.
Material and Methods: Twenty one male rats (200-250 gr) were randomly used in tree groups for the experiments(7 rats per group). First group as control, second group as untreated diabetic and third group as treated diabetic with Coenzyme Q10 (15 mg/kg). Second and third groups were diabetic with injection of alloxan(120 mg/kg). After six weeks treatment their serum lipids,were measured. Data were analyzed using SPSS software. Data were compared by Mann Whitney test.
Results: The results indicated that Coenzyme Q10 decreased serum triglyceride , cholesterole , LDL and VLDL in treated diabetic groups in comparision with untreated diabetic groups respectively, but serum HDL didn't increase(P<0.05).
Conclusion: Regarding the fact that Coenzyme Q10 decreases serum lipids. Our data suggest that Coenzyme Q10 has beneficial effects on diabetes induced complications.
Farhad Fathipur, Leila Zarei, Rahim Mohammadi,
Volume 23, Issue 0 (11-2021)
Abstract
Background: The aim of this study was to perform a functional and histological study of the effect of coenzyme Q10 using allografts in a rat sciatic nerve repair model.
Materials and Methods: 45 male rats were randomly divided into three groups of 15. The first group received 10 μl of sterile normal saline buffer solution intraperitoneally for one week. Buffer was injected intraperitoneally to each rat. In the third group, the left sciatic nerve was removed and each rat received the sciatic nerve extracted from the second group and was injected intraperitoneally with the same volume of coenzyme Q10 at a dose of 200 mg / kg / day for one week. Rats underwent histological evaluation and histomorphometric studies and sciatic nerve function index at 4, 8 and 12 weeks postoperatively.
Results: The morphometric and functional indices of the sciatic nerve in the third group were significantly different from the second group (P <0.05). These indicators were improved in the third group.
Conclusion: The results of this study showed that topical injection of coenzyme Q10 in the inflammatory phase after rat sciatic nerve resection accelerated the process of nerve regeneration by reducing the process of secondary damage.
