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Showing 3 results for Endurance Exercise
Evaluation and comparison of endurance training with fluoxetine 4 weeks on depression and heart 1β adrenergic receptors in male Wistar rats
Behzad Kohneshin, Maghsod Piree, Hasan Matinhomaee,
Volume 19, Issue 2 (10-2017)
Abstract
Background : Long-term exposure to anxiety and depression puts myocardium at risk of failure. Neurohormone Message caused be depression delivered to the heart by beta1 adrenoreceptor. The aim of this study was to survey and compare the effect of 4 weeks of endurance training with fluoxetine treatment on beta-adrenergic receptors in the male Wistar rat heart.
Materials and Methods: This research method is experimental. In this study, 24 male Wistar rats divided randomly into three groups. To each of the rats, exercise and supplementation group, fluoxetine 0.8 mg /kg of body weight LPS injected Intraperitoneal. Exercise group run for the 4-week on the treadmill at a speed of 20 meters per minute for 45 minutes each day. Fluoxetine group received 0.5 mg of oral fluoxetine. To prove the effects of LPS injection per and post FST test results analyzed using T-test for dependent samples. Pre and post-test FST data for each group using T-test at a significance level( α <0.05), and cardiac receiver data were analyzed by one-way ANOVA.  
Results: The mean density of beta-1 adrenergic receptors in the training group were significantly lower than the depressed group (P <0.05). The mean density of beta-1 adrenergic receptors in the training group were  not significant in comparison to the fluoxetine group.
Conclusion: Endurance training can prevent a significant increase in the density of adrenergic beta-1 receptors in the heart of the depressed rats.
 
The effect of six weeks of endurance training and Empagliflozin consumption on heart weight and electrical changes of the heart in male Wistar rat's diabetic with STZ
Eftekhar Mohammadi, Mohammad Fathi, Farzaneh Chehel Cheraghi, Afshin Nazari,
Volume 23, Issue 0 (11-2021)
Abstract
Abstract: (The effect of 6 weeks of endurance training and Empagliflozin consumption on heart weight and electrical changes of the heart in male Wistar rat's diabetic with STZ)
Introduction: One risk factor for heart disease is type 2 diabetes, which plays a major role in mortality from cardiovascular disease. The aim of this study was to evaluate the effect of 6 weeks of endurance training and Empagliflozin consumption on some indicators of electrical heart activity in male diabetic rats.
Methods:  40 male Wistar rats (250±20 g) with an age range of 8-10 weeks were randomly divided into five groups: Diabetes Exercise (D + EX), Diabetes+Exercise+Empagliflozin (D+EX+EMP), Diabetes + Empagliflozin (D + EMP), control diabetes (DC) and control group (CONTROL) were divided and were kept in laboratory conditions. The (D + EX + EMP) and (D + EMP) groups also received empagliflozin by gavage for the same period and daily. 48 hours after the completion of the protocol, rats were anesthetized and an electrocardiogram (ECG) was recorded and then cardiac tissue was isolated and dissected. One-way ANOVA and Kruskal-Wallis statistical tests and Tukey, Games-Howell, Tamhane's T2, Dunn and Dunnett'sT3 post hoc tests were used for statistical analysis.
Results:  Mean weight and blood glucose at the beginning of the study were not significantly different in the 5 groups, but after the end of the protocol, significant changes in weight, heart weight, serum glucose, QRS time, QT interval, QTc and ST height were observed in rats.
Conclusion:  The results of the present study showed that endurance exercise and the use of Empagliflozin can have a positive effect on the electrical conduction current of the heart of diabetic rats through reconstruction.

Effect of Eight Weeks of Endurance Training on the Protein Levels of Some Angiogenesis Indicators in the Cardiac Tissue of Rats with Morphine Withdrawal Syndrome
Katayoon Sahraneshin, Abbas Saremi, Mohammad Malekipouya,
Volume 25, Issue 1 (5-2023)
Abstract
Background: Exercise is a therapeutic procedure for addicts; however, its physiological mechanisms are not well understood. This study aimed to investigate the effect of eight weeks of endurance training on the levels of vascular endothelial growth factor and endostatin in the heart tissue of male rats with morphine withdrawal syndrome.
Materials and Methods: This experimental study was conducted on 32 male rats randomly divided into four groups of eight: healthy control (HC), endurance training (ET), morphine control (CM), and morphine+endurance training (M.ET). Two morphine withdrawal groups were addicted to 0.4 mg/ml morphine sulfate for 21 days. The exercise groups performed eight weeks of treadmill running. At the end of the study, all rats were killed, and their heart tissue was removed. Protein levels of the indicators in this study were measured by ELISA kits. The data were analyzed by Tukey’s one-way ANOVA test.
Results: The results of this study showed a significant decrease in VEGF levels (P<0.001) and a significant increase in ES (P<0.001) in the MC, compared to the HC. In addition, the increase in VEGF levels (P=0.014) and the decrease in ES (P=0.026) in the M.ET showed a significant difference, compared to the MC.
Conclusion: Endurance training may be useful in preventing negative changes in angiogenesis and metabolic parameters related to morphine, which should be considered in the rehabilitation of addicts.

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