Showing 18 results for Liver
Gholam Ali Sabzevarinezhad ,
Volume 6, Issue 3 (11-2004)
Abstract
Background: The flukes liver is common parasite of human and livestock that has effect on loss of economic. The human is final host parasites that infected of flukes liver. The fluke is a significant human health problem and damage liver of human.
Materials and methods: This cross sectional study was performed in the livestock of slaughtered in the slaughter house in Khormabad and 2912 livers of livestock were inspection.
Results: The results show rates infection in goats, sheep’s and cows with liver flukes was 8.6%, 8.2% and 7.9% respectively. And also infection rate was in 9.3% in female herbivorous and 8% in male herbivorous respectively.
Conclusion: in view of infection rate in flukes liver and loss of economic it is necessary to be industrialization in forage for nourishing of animals.
Mohammad Rafiee, Mohammad Taghi Ayatollahi , Javad Behboodian ,
Volume 6, Issue 4 (2-2005)
Abstract
Background: Mothers’ delivery is one of the most common hospitalization factors throughout the world and it’s modeling can explain distribution and effective factors on rising and decreasing of it. The objective of the present study was a suitable modeling for mother hospitalization time and comparing it with different models.
Materials & Methods: Present study is an observational and cross-sectional study with randomized sampled of 1600 mothers’ refered to Arak university treatment centers in the first seamester in 2004 for delivery. The following parameters were registered: hospitalization time as dependent variable, mother’s age and its square, mother job, having abnormal child, ordinal pregnancy or delivery and its square, number of abortions and its square, number of present children and its square, mothers’ residency, type of delivery, twice and triplets all were considered as independent variables. For analysis of data, advanced recent methods of countable data modeling were used. We also introduced an innovative method of analysis.
Results: The results of modeling of mothers’ hospitalization time showed negative binomial model was a suitable model because of unequal variance and means of dependent variables for explanation of mothers’ hospitalization time, having abnormal child, type of delivery (NVD, C&S) and twice delivery all were significant variables in this model. More specific models (Zero-truncated Poisson and negative binomial), showed to be more suitable for age and its square, having abnormal child, type of delivery, twice delivery and triplet delivery which were all significant variables in determining of mothers’ hospitalization time rates.
Conclusion: In this article, with a simple change of mothers hospitalization time, a suitable statistical model to explain them and modeling of these times were achieved. The suggested model could included more variables than conventional because of its higher specificity.
Fereidon Sabzi, Hasan Teimori, Fatemeh Nematollahi,
Volume 8, Issue 1 (6-2006)
Abstract
Background: Painless delivery using IV sedation is a method in which the pain and
anxiety delivery process will be reduced by IV injection of analgesic and sedative
drugs to the mother. In this method the health of neonate is taken into account.
Neonate’s health can be measured by Apgar score system. This research was carried
out to study Apgar score of the minutes 5 and 10 in neonates borne by painless natural
delivery and Cesarean C.
Materials and Methods: In this clinical trials study, 60 pregnant women referred
to Bakhtar hospital for natural delivery and Cesarean were selected using census
method including 30 painless deliveries and 30 women underwent Cesarean section.
A questionnaire was filled out for each of them and those who had not any problem,
were used as study group. Painless delivery through IV injection of Ketamine and
Midazolam and Cesarean section through general anesthesia were done, and Apgar
score in the minutes 5 and 10 in both groups were measured. No significant difference
in term of parity and age was observed in the both groups. 90% of the painless group
neonates in minute 5, and all of the neonates in the minute 10 had Apgar scores of 9
and 10. In Cesarean group, 20% of the neonates in minute 5, and 10% of the neonates
in minute 10, had Apgar scores of 7 and 8. Mann – Whitney test showed no
significant statistical difference between Apgar scores in the minutes 5 and 10 in both
groups. All the neonates had Apgar score of 7 to 10. The average interval time
between the two groups, was significantly different. Time interval was much more in
painless delivery (11.83 minutes versus 5.5 minutes).
Findings: Neonates of the painless delivery group, in comparison with Cesarean
group, didn’t have low Apgar score despite the usage of analgesic and sedative drugs
as well as passing of fetus from birth canal. Therefore, painless delivery with IV
sedation is a safe delivery.
Dr Majid Taati, Dr Masoud Alirezaei, Dr Mohammad Hadi Meshkatalsadat , Dr Bahram Rasoulian, Dr Omid Dezfolian, Shima Neamati,
Volume 13, Issue 2 (8-2011)
Abstract
It is well known that pathogenesis of ethanol in liver and kidney is directly related to increase of free radicals and oxidative stress which lead to the structural and functional damage in these two vital organs.
Materials and Methods: Fifty-six male Wistar rats were randomly divided into eight identical groups and were treated as follows: control group (normal saline), the ethanol-fed group (4 g/kg body weight), 3 groups received three doses of Ziziphus jujuba fruit extract (50, 100, 200 mg/kg body weight) and 3 groups were fed with three doses of Ziziphus jujuba fruit extract plus ethanol (50, 100, 200 mg/kg plus 4 gr /kg body weight). All treatment were applied once daily by gastric gavage for 60 consecutive days. Samples of serum, liver and renal tissues were achieved for analysis of serum components, antioxidant enzymes, and thiobarbituric acid reactive substances (TBARS) from rats.
Results: Superoxide dismutase and glutathione peroxidase (GPx) liver activities were decreased significantly in ethanol group compared to the control group. While, only glutathione peroxidase activity of liver increased significantly by administration of Z.jujuba fruit extract (200 mg/kg). The activity of kidney GPx, increased significantly in ethanol group compared to the control group. Also, kidney GPx activity decreased significantly in Z.jujuba fruit extract and ethanol group (200 mg/kg plus 4gr/kg) in comparison with the control group. In the present study, liver TBARS concentration, indicator of lipid peroxidation, increased significantly in ethanol group compared to the control group (p<0.05).
Conclusion: Pretreatment by Z.jujuba fruit extract can protect liver and kidney against ethanol–induced oxidative stress.
Kobra Karami , Katayon Bakhtiar , Bahman Hasanvand , Shirzad Safary , Shirin Hasanvand ,
Volume 14, Issue 4 (12-2012)
Abstract
Background : The aim of this study is to compare the quality of life and public health after natural and cesarean delivery in women referred to Khorramabad health centers in 2009-2011.
Materials and Methods: In this cohort study all pregnant women referred to health centers in Khorramabad were studied. 380 persons participated in the study selected using purposive sampling method. Data collection was done in 18 months. The information was collected in steps (a): the last month of pregnancy and (b):eight weeks after delivery.GHQ questionnaire was used in order for primary assessing, its validity confirmed by the World Health Organization. Data were analyzed using logistic regression, chi square test, Mann-Whitney at 5% significance level with SPSS software, version 16.
Results: 250 subjects out of 380(146 natural deliveries and 104 cesarians) filled out interview forms and questionnaires. The results show that there are statistically significant differences between physical domain scores (P = 0.001) and mental scores (P = 0.02)which show significant differences in quality of life and in environment and social areas and total, no statistically significant difference was observed. Chance of causing disease symptoms in women with cesarean delivery in the scale of physical complaints was 09.3 times (P = 0.001), depression 75.1 times (P = 0.02) and impaired social interaction 68.1 times (P = 0.04) greater than women with vaginal delivery, all of which are significant at the 5% level of statistical error.
Conclusion:Quality of life in its various aspects and general health in mothers with normal delivery, better grades and better shows.
Soodabeh Aliashrafi , Mehrangiz Ebrahimi-Mameghani , Pardis Irandoost , Fatemeh Hamzavi,
Volume 15, Issue 5 (3-2014)
Abstract
Background : Non-Alcoholic Fatty Liver Disease (NAFLD) is the most common liver disease. NAFLD is characterized by elevated liver enzymes and serum ferritin concentration due to damage and abnormal function of liver cells. Increased level of serum ferritin as a parameter of liver function is commonly observed .The aim of this study was to determine the agreement between serum liver with liver and ferritin echogenicity in NAFLD patients.
Materials and Methods: This cross-sectional study was carried out on 60 NAFLD patients confirmed by ultrasonography in Tabriz. Fasting blood samples were taken for assessment of Alanin aminotransferase, Aspartat aminotransferase and ferritin level. Weight and height were measured. Liver enzymes ratio were estimated and classified into tertile.
Results: The mean of serum ferritin was126.34±108.25 ng/ml and was significantly associated with severity of liver echogenisity (p=0.016). Significant relationship was observed between fatty liver severity and ALT/AST ratio (p=0.004) with good agreement (Kappa value= 68.3%) while the ratio of ferritin to liver enzymes was not significantly associated with the severity of NAFLD.
Conclusion: This study suggests significant agreement between severity of fatty liver and ferritin and liver enzymes ratio in NAFLD patients but not with the ratio of ferritin to liver enzymes.
Bager Seyed Alipour , Masoomeh Oshrieh , Ramezan Khanbabaee,
Volume 16, Issue 3 (1-2015)
Abstract
Background :Nowadays, nanotechnology has been developing rapidly and may have considerable effects on industry, society and the environment. In this research the toxicity properties of zinc oxide nanoparticles with a size of 20 nm on enzyme and liver tissue of NMRI mice were studied. Materials and Methods: This experimental study was performed in standard conditions on 25 NMRI mice with an average weight of 30 ± 3 g so that they received different doses of zinc oxide nanoparticles, an a days, for 15 days intraperitoneally. Then, blood samples were taken on day 17 of NMRI mice. The collected tissues were washed with saline and fixed in Boin΄s fluied buffer and stained with hematoxylin and eosin for histopathology evaluation. After data collection, statistical analysis was done using SAS software. Results: The results showed that activity of ALT enzyme at concentrations 50, 100, 150 and 200 mg/kg ZnO Nps at a significant level (p<0.05) increased in comparison with the control group. Histopathological investigation showed that zinc oxide nanoparticles caused severe damage in liver. Damaged liver cells develop leaky membranes and escape of intracellular enzymes into the bloodstream. Conclusion: Our findings showed that using different concentration of zinc oxide nanoparticles could be caused undesirable effects on liver with damage to hepatocyte and level elevation of liver enzymes.
Mohamad Hadi Emamat, Parvin Mirmiran, Azita Hekmatdoost,
Volume 18, Issue 1 (5-2016)
Abstract
Background: The prevalence of non-alcoholic fatty liver disease (NAFLD) increased globally. Prevalence of NAFLD in general population estimated as 10-24%. Insulin resistance and fat accumulation in liver cells playing an important role in this disease. Recently usage of antioxidants in prevention and treatment of disease is considered. Quercetin is an antioxidant in flavonoids group. In the present study we aim to determine the effects of quercetin on NAFLD.
Materials and Methods: After searching relevant keywords such as NAFLD, antioxidant, quercetin, insulin resistance, liver activity, lipid and inflammation, 20 fulltext papers and 12 abstracts that which were in accordance with the aim of this study were evaluated.
Results: Quercetin in addition to its inherent antioxidant activity can reduce inflammation; improve serum lipids; decrease lipid accumulation in the liver; improve insulin resistance by increasing hexokinase activity, glycogen content of muscle and liver, phosphorylation and activation of insulin receptors; and promote liver activity by reducing serum liver transaminase enzymes and inhibiting the production of liver fibrotic factors.
Conclusion: In animal and cell-culture studies, the application of quercetin was shown to have antioxidant, anti-inflammatory, hypolipidemic, insulin resistance reduction and antifibrotic effects. All these factors clearly show that quercetin can be counted as one of the important dietary factors having a role in the prevention and also treatment of NAFLD.
Amir Khosravi, Omid Ali Omidali, Bahram Rasoulian, Seiros Choobineh,
Volume 19, Issue 1 (6-2017)
Abstract
Background : Despite regular exercise benefits, acute exhaustive exercise elicits oxidative damage in liver. The present study aims to investigate the effects of a week aqueous Saffron extracts consumption on malondialdehyde (MDA) and superoxide dismutase (SOD), catalase (CAT) and glutathione peroxidase (GPx) Antioxidant enzymes alterations content of liver of young male rats following an acute bout of exhaustive exercise.
Materials and Methods: We randomly classified 48 Wistar male rats were assigned into following three groups 16 rats per group: 1) control 1 (saffron extract solvent); 2) control 2 (saffron extract solvent+ training); 3) experimental (aqueous saffron extract, 50 mg/kg + training).After a week, half of each group were killed without exhaustive, but the remaining rats (control 2 and experimental) were killed immediately after performed an acute bout of exhaustive exercise and SOD, CAT , GPx and MDA in their liver were measured.
Results: The MDA level and anti-oxidant enzymes activities didn’t change significantly, in the liver tissue in experimental group unlike control group of rats following an acute bout of exhaustive exercise
Conclusion: The consumption aqueous extract of saffron stigma in rats leads to the reinforcemen of the antioxidant defense system and prevented the MDA level and anti-oxidant enzymes defense system in the liver tissue of rats following an acute bout of exhaustive exercise.
Bahman Hasanvand, Rahman Soori, Sirous Choobine, Ali Akbarnejed,
Volume 19, Issue 4 (10-2017)
Abstract
Background: This study aimed to investigate the effect of eight weeks of interval training on gene expression of liver X receptors (LXR) in Wistar male rats.
Materials and Methods: In this study, 24 male wistar rats (200-250 g) were randomly used to three groups for this purpose, 24 male Wistar rats were prepared and divided into three groups: control (8 = n), high intensity intermittent exercise (8 = n) and continuous submaximal exercise (8 = n), respectively. The treadmill exercise program was performed for eight weeks, three days a week for 40 minutes. High intense exercise protocol, 30 minutes running periodic (every period of four minutes and two minutes running with 90-85% of VO2 max intensity active recovery with 60-50% of VO2 max) three days a week for eight weeks. Also, the continuous training group under maximum was an exercise intensity equivalent to 50 to 55 percent of maximum oxygen consumption of the mice.
Results: The results showed that there was a significant difference between the four groups in the gene expression level, after data analysis and test research hypotheses, findings of this study show that the expression of LXR alpha gene, apolipoprotein 1, ABCG1 a significant increase in intensity interval exercise than the control group (p = 0.004). The results also showed a significant difference between the three groups in the expression of LXR beta and apolipoprotein 2, SR-BI does not exist. Although the results showed a slight increase in groups of periodic training and continuing slight increase, but this has not led to a significant difference.
Conclusion: Overall results indicated the superiority of intense interval training than submaximal exercise in reverse cholesterol transport is continuous. Intense interval training by increasing hepatic expression of the receptor gene as well as the main cause of the liver and eventually out HDL receptors can play an important role in reducing cardiovascular diseases such as atherosclerosis.
Aziz Zeinvand Lorestani, Rahim Mirnasouri, Masoud Rahmati,
Volume 20, Issue 2 (6-2018)
Abstract
Background : Fatty liver disease can result in liver damage along with viral hepatitis, and accelerated disease progression can result in liver tissue fibrosis and liver damage. Aerobic training can reduce the level of liver enzymes (Alp, ALT, and AST) in order for possible treatment of fatty liver disease with aerobic exercise. The present study was performed to assess the effects of Aerobic training on NAFLD.
Materials and Methods: The present study was a randomized control trial that was performed on 24 obese children (7 to 11 age) with NAFLD, that were divided randomly into two groups (control and experimental). Aerobic exercise was carried out for eight weeks for the experimental group. Before and after the training period, measurements of liver enzyme levels (ALP, ALT, and AST) and liver ultrasound was done. To analyze the data, independent-samples T testing was used.
Results: The results showed that performing aerobic training reduced the levels of liver enzymes ALT (p=0.007), AST (p=0.024), and ALP (p=0.048) in the experimental group significantly.
Conclusion: Aerobic training is recommended as a non-drug treatment for fatty liver disease.
Hoseyn Dalvand, Ahmad Hematfar, Naser Behpoor,
Volume 21, Issue 1 (5-2019)
Abstract
Background: Curcumin is an active ingredient in turmeric, which is used as herbal medicine for the treatment of certain diseases. The aim of this study was to investigate the effects of two weeks of exhaustive swimming and supplementation of curcumin on alcohol induced liver damage biomarkers in male wistar rats.
Materials and Methods: In this study, 32 male wistar rats were randomly selected and divided into 4 equal groups: control, training, supplemental curcumin, and training with curcumin supplement. At first, every 8 hours for 4 days, alcohol was gavaged to all groups, proportional to the body weight of each rat. This was followed by an alcohol withdrawal period. After that, the practice period began, including long-term swimming in water, for the exercise group, and the curcumin supplement with exercise group. Finally, blood samples were taken from the heart under anaesthetic
Results: Curcumin had no significant effect on AST (P = 0.401) and ALT (P = 0.978) and the ratio of these two enzymes (p = 0.657). Exercise significantly reduced AST (P = 0.022), but did not significantly decrease ALT (P = 0.759) or the ratio of these two enzymes (p = 0.225). Exercise and supplementation interaction did not significantly decrease ALT (P = 0.462) or AST (P = 0.073) activity or the AST / ALT ratio (P = 0.520).
Conclusion: The reduction of liver damage markers in this study suggests that exercise and curcumin consumption may, through protective effects, improve the negative effects of alcohol on the liver, and prevent alcohol induced liver disease.
Safoura Dehghan, Ali Neamati, Pouran Ardalan,
Volume 21, Issue 2 (9-2019)
Abstract
Background: One of the important aspects of nanotechnology for use in biology is the production of nano materials with controllable size, chemical characteristics and dimensions. It can be said that the purpose of nanotechnology is to control each atom and molecule. It is now known that nanoparticles are capable of destroying cancerous cells without side effects on normal cells. Liver cancer is the fifth most common cancer in the world and the third most common cause of cancer deaths in the world. The purpose of this study was to investigate the anti-inflammatory properties of silver nanoparticles synthesized by the Amaranthus Cruentus plant on Hep G2 liver cancer cells.
Materials and Methods: The studies in this research included in vitro experiments. The anti-inflammatory effect of silver nanoparticles produced by the Amaranthus Cruentus plant was evaluated using the Real-Time PCR technique and assaying the expression of IL-1b and IL-10 genes at concentrations of 50, 100 and 200 μg/ml.
Results: The findings from the gene expression showed that the silver nanoparticles produced by the Amaranthus Cruentus plant significantly reduced anti-inflammatory activity by decreasing the expression of the IL-1b pre-inflammatory gene expression at the level of P <0.001 and increasing the expression of the anti-inflammatory IL -10 meaningful at the level of P <0.001.
Conclusion: Based on the results of this study, silver nanoparticles of the Amaranthus Cruentus plant have anti-cancer properties, and the expression of the gene leading to inflammation, IL-1b, decreased meaningfully. In addition, there was a significant increase in the expression of the IL-10 gene. Given these features, it is likely that the use of these nanoparticles, after supplementary studies, can be suggested as complementary data in the treatment of cancer and could have other biomedical applications.
Khatreh Torabi, Nooshin Naghsh, Mahbobeh Madani,
Volume 22, Issue 1 (4-2020)
Abstract
Background: Carotenoids comprise a significant group of natural pigments produced by plants and some microorganisms such as fungi. These useful pigments have beneficial properties, including the antioxidant property. The goal of the present project is to produce carotenoids by Fusarium oxysporum fungus and its effect on liver enzymes in male mice.
Materials and Methods: Fusarium exosporium fungus was cultured in a suburodecroserase agar medium. In this study, carotenoids were first extracted by the solvent method under optimal conditions of the solvent mixture of acetone, methanol and petroleum ether for 24 hours. The drying process of pigment extraction was carried out using Davis method. In the next stage, 24 male mice were randolmly divided into three groups of eight mice. Two treatment groups received carotenoid via intraperitoneal injection (16 and 32 mg / kg), and the last group received this product in the control group. 0.2 mL was of physiologic serum was injected intraperitoneally. Subsequently, heart blood was collected from the rats and liver factors were evaluated. The results were analyzed using SPSS 21 software and all the data were compared using the ANOVA method.
Results: The results showed that carotenoid extracted from Fusarium oxysporum fungus altered the activity of liver enzymes.The concentration of SGPT and ALP enzymes significantly decreased in the injectable group (32 mg / kg).
Conclusion: The antioxidant properties of carotenoids in thick doses reduced the activity of liver enzymes.This function is probably due to the antioxidant properties of carotenoids and the oxidative stress control and radical trapping of free radicals. Given the physiological similarities between the human body and mice, the use of high doses of carotenoids in food industries is recommended.
Roghayeh Ehtesham, Masoumeh Nezhadali, Mehdi Hedayati,
Volume 23, Issue 3 (8-2021)
Abstract
Background: Non-alcoholic fatty liver disease (NAFLD) is the most common liver disease. The NAFLD is associated with obesity, insulin resistance, and dyslipidemia. Vaspin is a newly discovered adipokine that has several functions, including regulation of carbohydrate and lipid metabolism. This study aimed to investigate the relationship of vaspin levels with NAFLID as well as anthropometric and biochemical parameters.
Materials and Methods: This case-control study was conducted on a total of 150 participants who were divided into the case (with NAFLD; n=75) and control groups (n=75). The serum levels of vaspin and insulin were measured by ELISA kit, and other variables were determined by standard methods.
Results: There was no significant difference between the patients with NAFLD (grades 1, 2, and 3) and healthy controls (P>0.05) in terms of vaspin levels. Moreover, the patients with NAFLD had significantly higher body mass index, levels of transaminases, triglycerides, systolic blood pressure, insulin, and insulin resistance, compared to the control group (P<0.05). In this study, an inverse correlation was observed between vaspin and diastolic blood pressure with cholesterol (P<0.05). However, no association was found between vaspin and lipoproteins, as well as insulin resistance and liver enzymes (P>0.05).
Conclusion: The findings showed no relationship between vaspin and NAFLD. However, serum vaspin levels are correlated with cholesterol levels and diastolic blood pressure (in all subjects).
Seidamir Pasha Tabaeian, Meysam Behzadifar, Aziz Rezapour, Samad Azari, Masoud Behzadifar,
Volume 25, Issue 1 (5-2023)
Abstract
Background: Non-alcoholic fatty liver disease (NAFLD) can lead to serious complications and have adverse effects on physical and mental well-being in young people. This review aimed to investigate the prevalence of NAFLD among Iranians aged 6 to 18 years.
Materials and Methods: This study was conducted by systematic review and meta-analysis methods. A detailed search was performed on various international and Iranian databases from January 2000 to January 2023. The international databases included Pubmed, Scopus, Embase, and Web of Science, while the Iranian databases consisted of MagIran and SID. The quality of the selected studies was assessed using the Newcastle-Ottawa Scale. Overall prevalence was estimated using the random-effects model and DerSimonian and Laird criteria with a 95% confidence interval. The Q-Cochrane test and the I2 index were used to assess heterogeneity between studies. In addition, a sensitivity analysis was performed to ensure the reliability of the results. Data analysis was performed in Stata12 software.
Results: Finally, 9 studies were selected for analysis, of which, 7 studies were of good quality, while 2 studies were of average quality based on the assigned scores. According to the random-effects model, the overall prevalence of NAFLD in Iranian individuals aged 6 to 18 years was 35% with a 95% confidence interval (24% to 46%).
Conclusion: The results of our study revealed a high prevalence of NAFLD in Iranian individuals aged 6 to 18 years. Policymakers and healthcare planners in Iran must implement educational programs aimed at the prevention and early diagnosis of this disease.
Nasrin Rastegarvand, Hoorieh Soleimanjahi, Ehsan Arefian, Mahmoudreza Pourkarim, Fatemeh Saadatpour, Rahil Ghanbarnasab Behbahani,
Volume 25, Issue 3 (11-2023)
Abstract
Background: Gene transfection is a powerful tool for changing cell function, which is used for treating various diseases. Nevertheless, various studies show that despite the variety of gene transfer methods, there are significant limitations in the application of each method. The present study aimed to compare two methods of gene transfer using PEI and Lipofectamine compounds in cancer cell.
Materials and Methods: In this study, Caco-2 and HCT-116 were used as target cells, and HEK-293 cells were used as control cells. For this purpose, initially, gene transfer was performed using PEI and Lipofectamine, and then their results were compared with each other based on the expression of GFP protein.
Results: The results of this study showed that although gene transfer was carried out in HEK-293 cells at a favorable rate, this process was very insignificant in colorectal cells. In addition, in the meantime, some differences were observed between the amounts of gene transfer in colorectal cells, so that the amount of transfection in Caco-2 cells was lower than that of the HCT-116 cells.
Conclusion: The degree of acceptance of foreign genes in cells depends on several factors, including the type and origin of the cell. Since cancer cells have undergone many genetic changes, their genetic manipulation is associated with many limitations. For this reason, it is recommended to use other methods, such as cell selection by antibiotics and preparation of stable cell lines to reach a high level of gene transfer in these cells.
Peyman Astaraki, Maryam Ahadi, Zahra Khademi, Farahnaz Changaee,
Volume 26, Issue 2 (6-2024)
Abstract
Background: The health system transformation plan has been implemented since 2014, and one of its goals is the reduction of cesarean rate to 25%-30%. The present study aimed to assess the rate of cesarean delivery and vaginal delivery before and after the implementation of the health system reform plan in Lorestan, Iran.
Materials and Methods: This descriptive study was conducted in 2020. The research population included all the women who had given birth in one of the public hospitals of Lorestan province during 2011-2016. The sampling method was the census, which was based on the statistics of the vice-chancellor of treatment at Lorestan University of Medical Sciences. After data collection, they were analyzed using descriptive statistics.
Results: The results of the study demonstrated that contrary to expectations, the cesarean section overall rate increased by about 3.4% after the implementation of the health system transformation plan, compared to before the implementation of this plan. It is worth noting that in some hospitals, including Khorramabad Asali Hospital, Khorramabad Social Security Hospital, and Broujerd Kowsar Hospital, the rate of cesarean section increased by 4.6%, 6.5%, and 5.9%, respectively, after the implementation of the health system transformation plan.
Conclusion: It seems that according to the rate of cesarean delivery in this province that is higher than standard and the ineffectiveness of the health system transformation plan in this field, more efforts should be made with the use of extensive programs in order to increase the awareness and culturalization of the society.
