Showing 11 results for Multiple Sclerosis
Ghasem Mosayebi , Ali Ghazavi , Hosein Salehi ,
Volume 8, Issue 3 (11-2006)
Abstract
Background: Leukocyte infiltration into the central nervous system (CNS) in diseases like multiple sclerosis (MS) and experimental autoimmune encephalomyelitis (EAE) have been implicated in subsequent disease pathogenesis and progression. It suggested that vitamin D3 (active form of vitamin D) ameliorates the symptoms of EAE when administered after the onset of clinical sings. The aim of this study was to understand the efficacy of vitamin D3 against EAE, we examined the effect of vitamin D3 on the leukocyte infiltration into the brain of male C57BL/6 mice with MOG35-55- induced EAE.
Material and methods: Male C57BL/6 mice were divided into two therapeutic groups (n=8 per group) with age and weight-matched as follow: Vitamin D3-treated EAE mice (5μg/kg/every two days of vitamin D3 given i.p.) from day -3 until day +19 after disease induction. Non-treated EAE mice (EAE control) received vehicle alone with same schedule. In addition, 5 age and weight-matched male C57BL/6 mice served as normal (non-EAE) controls.
Results: Vitamin D3-treated mice had significantly less clinical score of EAE (3.2±0.8) than non-treated mice (5.3±0.44), (p<0.001). Also, there was a significant difference between vitamin D3-trated and non treated mice (p<0.01) in relation to the number of the infiltrating cells in the brain.
Conclusion: These results indicate that vitamin D3 treatment reduces infiltration of leukocytes into the brain of EAE mice, and ameliorate the disease. Thus, vitamin D3 treatment may be of therapeutic value against inflammatory disease processes associated with infiltration of activated mononuclear cells into the tissue.
Ehsan Hejazi , Reza Amaani , Naser Sharafodin-Zadeh ,
Volume 9, Issue 3 (10-2007)
Abstract
Hejazi E1, Amaani R2, Sharafodin-zadeh N3 1. M.sc Student of Nutritional Sciences, Department of Nutritional, Faculty of Para-Medicine, Jondi-shapour University of Medical Sciences 2. Associate Professor, Department of Nutritional, Faculty of Para-Medicine, Jondi-shapour University of Medical Sciences 3. Assistant Professor, Department of Neurology, Faculty of Medicine, Jondi-shapour University of Medical Sciences Abstract Background: Multiple Sclerosis (MS) is a chronic, immune-mediated inflammatory and neurodegenerative disease of the Central Nervous System (CNS), with an etiology that is not yet fully understood. Increasing evidence shows that oxidative stress plays an important role in the pathogenesis of MS. The aim of this study was to compare dietary intake of antioxidants and serum levels of Total Antioxidant Status (TAS) in MS patients with that of normal subjects. Materials and methods: Serum levels of TAS and dietary intake of the main antioxidants of twenty one MS patients (16 women) were compared with age and gender matched healthy controls. Serum samples were collected and frozen for further spectrophotometer analysis. Food frequency questionnaires and 24-hour dietary recalls for 3 days of all subjects were obtained. Results: There was no significant difference in serum levels of TAS between the two groups. No significant difference was seen in consumption of dietary antioxidant sources between them. Additionally, daily intake of vitamin C, vitamin E, vitamin A, folate and dietary fiber were not significantly different between groups. Conclusion: There is a lack of evidence on the possible relationship and benefits of dietary antioxidant in MS patients. More research is required to assess the effectiveness of diet interventions on antioxidant status in MS patients.
Shoheir Mazaheri , Mohammad Mehdi Fazlian , Akram Hossein Zadeh ,
Volume 9, Issue 4 (2-2008)
Abstract
Mazaheri Sh1, Fazlian MM2, Hossein Zadeh A3 1. Assistant Professor, Department of Neurology, Faculty of medicine, Hamedan University of Medical Sciences 2. General practitioner, Specialty and Subspecialty Hospital of Besat, Hamedan University of Medical Sciences 3. General practitioner, Hamedan Health Center Abstract Background: Multiple Sclerosis (MS) is one of the most common causes of chronic neurological disability in young adults and geographical diversities and differences have been reported in its occurrence. For more concise data about MS in the West of Iran, in this study, the clinical and epidemiological features of MS patients were evaluated at the University Hospital of Hamedan. Materials and methods: Data for 155 MS patients attending Hamedan University of Medical Sciences’ MS Clinic between the years of 2004 and 2005 who had fulfilled Poser criteria for clinically definite MS were reviewed. Moreover, early and late MS onsets for clinical and epidemiological differences were compared. Results: The early onset MS was reported in 23(14.83%) subjects who were 18 or less years old of whom 7(30.44%) were male and 16(69.56%) were female. The age mean was 16.22±16.36. 17(73.92%) patients were classified as having relapsing-remitting MS, while 5 patients (21.73%) were classified as having secondary progressive MS and 1 patient (4.35%) was classified as having primary progressive MS. There were no significant differences in clinical and epidemiological features for MS subtypes in the institute. 12.9% of patients had positive family history for the disease and one patient had a benign MS. The clinical and epidemiological features of early and adult onset MS were not significantly different in the study. Conclusion: The present study confirmed that while the clinical and epidemiological features of MS patients in Hamedan university hospital were similar to those in other Iranian institutes in most of the cases, early onset MS was more common.
Firuzeh Payamani , Dr Ali Akbar Nazari, Haydeh Noktehdan, Abas Mehran, Mohammad Ali Sahraian,
Volume 13, Issue 2 (8-2011)
Abstract
Multiple sclerosis is unpredictable and is amongst the important diseases which cause changes in life style and gradually leads to inability. There is a close relation between health and life style, so that one can prevent from rate of disease attacks, by his/her life style modification. Therefore recognition life style for educational planning in MS patients is very important.
The aim of this study was to determine life style of MS patients referred to MS association in Tehran city in 2008.
Materials and Methods: This descriptive cross-sectional study was carried on 200 men and women suffering from MS. Data gathering tool was a questionnaire and method was interview. Data were analyzed using descriptive and inferential statistics (Chi- Square and Fisher,s exact test) and SPSS software.
Results: 38.5% of the samples in self care dimension were desirable. Findings also indicated that nutrition in the samples (78%) was relatively desirable. Other results showed that non smoking (83%) was desirable and sleep pattern and rest (45%), and stress coping (50.5%) was undesirable. Findings showed there was significant relation between educational level, supportive resources, number of relapse and self care dimension in life style. Also, relation between marriage status, family income and nutrition dimension in life style was significant too.
Conclusion: According to the results of this study, life style in some dimensions was undesirable. These non healthy behaviors can effect on severity and relapse of disease and ultimately have bad influence on the quality of life in these patients. Therefore, change and modification and improvement in life style in these patients seem to be essential that we can access to it with comprehensive educational programs.
Azam Foroughi Pour , Rokhsareh Meamar ,
Volume 16, Issue 4 (2-2015)
Abstract
Background: Multiple Sclerosis (MS) is the most common demyelinating disease. An autoimmune basis has been confirmed for pathogenesis of MS, and studies have shown that sex hormones such as testosterone may play a role in the disease mechanism. The purpose of this study was to survey these changes in MS patients. Materials and Methods: 31 MS patients were included in this cross-sectional study and matched with 60 healthy coses as control group. The serum testosterone level of both groups were randomly determined in follicular and luteal phases. Then the testosterone hormone levels and their correlation with the disease were studied. Results: In this study, testestrone level in patients was 0.461 ± 0.3 ng/ml in the follicular phase compared to controls with mean level of 0.82 ± 0.4 ng/ml(pv=0.011) .Mean testestrone level in female patients was 0. 58 ± 0.7 ng /ml in the luteal phase compared to controls with mean level of 0.88± 0.3 ng/ml (pv = 0.03). Patients with MS had significantly lower testosterone, in the follicular and luteal phase, but no relation with the disease was observed. Conclusion: Testestrone has a positive relation with MS. Further studies to determine the cause of relation and effect of endocrine system on MS pathogenesis and treatment are suggested.
Hosein Shahrokhi, Amir Letafatkar, Amir Barati, Hasan Daneshmandi, Ali Ashraf Jamshidi,
Volume 19, Issue 1 (6-2017)
Abstract
Background : Multiple sclerosis (MS) is a chronic progressive disease on the central nervous system with signs and symptoms such as fatigue and reduced functional capacity. The purpose of this study was to assess the effect of core stability exercises on functional capacity and fatigue in patients with multiple sclerosis.
Materials and Methods: The present quasi-experimental study used a pretest-posttest design. The subjects with the age of 20-40, expanded disability status scale (EDSS) 1-4 and purposefully and voluntarily selected and randomly allocated to the experimental and control groups. Training program for groups were carried out in eight weeks, three sessions per week and each session one hour. Functional reach test (FR) was used to measure functional capacity and Fatigue Severity Scale (FSS) was used to measure fatigue. The data were analyzed by paired and independent sample t-test at a significance level of 0.05.
Results: The results showed that core stability training led to a significant increase in functional capacity and a significant reduction in fatigue (P≤ 0.05). Also significant differences observed in functional capacity and fatigue scale in post-test between experimental and control groups (P≤ 0.05).
Conclusion: According to research findings, the core stability exercises can be factor for considerable improvement in functional capacity and reduced fatigue in patients with multiple sclerosis. . Furthermore, the respective specialists can use these exercise as a complementary treatment along with the drug therapy for patients with multiple sclerosis.
Farzaneh Bayat, Leila Bayat,
Volume 21, Issue 2 (9-2019)
Abstract
Background: The aim of this study is The prediction of executive function of planning based on chronic stress, sensory processing sensitivity in patients with multiple sclerosis.
Materials and Methods: A sample of 100 patients with multiple sclerosis of Iran,s MS Society selected by available sampling and completed two scales, chronic stress scale, sensory processing sensitivity and neuropsychological testing of Tower of London. Data were analyzed by SPSS software version 17.
Results: the stepwise multiple regression analysis showed that among subscales of sensory process sensitivity, only low sensory threshold can predict function and time of planning. Whereas low sensory threshold predict 27 % variance of function of planning(p<0/001)and through entering of chronic stressto into the model sensory threshold and chronic stress predicted 0/37% variance of function of planning simultaneously(p<0/001). Also low sensory threshold predicted 27 % variance
Of tim of planning(p<0/005) and through entering of chronic stressto into the model increased to 33 %.
Conclusion: In order to explain the findings of this study it can be concluded that chronic stress lead to release stress hormone, that damage hypocamp and frontal lobe. Those both supress unrelated informations and establish planning and problem solving strategies. And low sensore threshold eliminates and deters stimuluses and lead to information processing disorder and planning impairement.
Pardis Mirmoeini, Mohammad Hossein Bayazi, Javad Khalatbari,
Volume 22, Issue 4 (1-2021)
Abstract
Background: The aim of this study was to compare Acceptance and Commitment Therapy with Compassion focused Therapy on Romantic, Family and Social loneliness in patients with Multiple Sclerosis.
Materials and Methods: In a quasi-experimental design, with pre-test and post-test and a control group, 45 patients with Multiple Sclerosis were selected among the patients referred to the MS clinic in Tehran province in 1398 and devided randomized in two experimental groups Acceptance and Commitment Therapy , Compassion focused Therapy and one contro; group. All three groups completed the Adult Socio-Emotional Feeling Questionnaire (SELSA-S) in two stages before and after the intervention. The experimental groups participated in eight sessions of Acceptance and Commitment Therapy, the second experimental group participated in ten sessions of Compassion Focused Therapy, the experimental group did not receive any intervention, and the post-test sessions were performed at the end of the sessions. In order to test the research hypothesis, the results were analyzed by multivariate analysis of variance (MANCOVA) and SPSS21.
Results: The results showed that Compassion Focused Therapy and Acceptance and Commitment Therapy were effective on the feeling of loneliness in patients with Multiple Sclerosis and with 95% confidence it can be said that Acceptance and Commitment therapy is more effective.
Conclusion: According to the obtained results, these interventions can be used along with drug treatment for Multiple Sclerosis patients as a useful and complementary treatment method.
Ali Abedi, Mohsen Ghofrani, Hadi Akbari,
Volume 23, Issue 0 (11-2021)
Abstract
Background: Today, Multiple Sclerosis (MS) is the most common neurological disease among young adults. Physical activity is mentioned as the most important factor in preventing diseases and living a healthy life. Although advances in disease-modifying drugs have helped stabilize the course of MS, which increases life expectancy, in most MS patients the symptoms worsen over time. In this regard, physical exercise programs are considered as a safe and tolerable tool. The aim of this study was to conduct a systematic review of the effects of exercise on some pro-inflammatory and anti-inflammatory factors in people with MS.
Research Method: In this study, articles related to keywords were searched in PabMed, ScienceDirect, Scopus and Web of Science specialized databases in English and Jihad Daneshgahi, Mag Iran and IranDock databases in Persian. Inclusion criteria include: Persian or English language of the article, availability of the full text of the article, desired time period, evaluation of the effect of regular physical activity in patients with MS, evaluation of pro-inflammatory and anti-inflammatory factors and exclusion criteria The use of other methods and interventions, such as the use of drugs other than the usual drugs or supplements during the training period.
Results: Out of 408 articles received from domestic and foreign databases in the last 20 years, 19 articles were reviewed after applying input and output variables. The Pedro Information Evidence Database (PEDro) scale was used to evaluate the quality of the studies. In the studied studies, aerobic or endurance exercises (6 studies), resistance (5 studies), combination (8 studies) have been used. Among inflammatory and anti-inflammatory factors, brain-derived neurotrophic factor (BDNF) in eleven studies (57.9%) and interleukin 17 (IL-17) in eight studies (42.1%) were the most widely used indices.
Conclusion: We conclude that although interventions such as exercise have improved the functional and clinical outcomes of patients with multiple sclerosis, these improvements may not be due solely to changes in cytokine levels or inflammatory markers. Exercise is an accessible alternative that not only does not increase inflammation or disease severity, but also helps these patients by reducing their risk of secondary disorders and restrictions on community participation.
Afshin Moghadasi,
Volume 24, Issue 3 (12-2022)
Abstract
Background: Multiple sclerosis (MS) causes an asymmetric pattern in the strength of the muscles on both sides of the body. So far, the amount of asymmetry in the isometric strength of knee muscles in Iranian women with MS has not been studied. Therefore, this study aimed to investigate the extent of bilateral asymmetry in the isometric strength of knee flexor and extensor muscles in Iranian women with MS.
Materials and Methods: This is a causal-comparative study. From 93 MS patients, 27 females (20-50 years with an expanded disability status scale of less than 4) were selected as the statistical sample. Maximal voluntary isometric contraction (MVIC) of the knee flexor and extensor muscles was measured at the angles of 20 and 70 degrees using a Biodex isokinetic dynamometer. The asymmetric score in muscle strength was also calculated as a percentage of the ratio between the peak torque isometric strength in the muscles of the weak leg to the strong one. The data were analyzed using the correlated t-test at the 95% confidence level.
Results: The results showed a significant difference in MVIC of the knee extensor and flexor muscles between the strong and the weak leg at the angles of 20 and 70 degrees in the statistical sample of the present study (P=0.001). Additionally, in terms of asymmetry in strength, the results showed that the highest percentage of bilateral asymmetry between strong and weak legs was in the strength of knee extensor muscle at the angle of 20 degrees (31.2%), and the lowest percentage was in knee flexor muscles at 70 degrees (16.1%).
Conclusion: The results of this study showed that the asymmetric rate in the strength of flexor and extensor muscles of the strong and weak leg is about 16% to 31% in Iranian women with MS with an expanded disability status scale of less than 4.
Saba Akbari, Abdolhossein Parnow, Ahmad Mohammadi Moghaddam, Somayeh Dashti,
Volume 25, Issue 1 (5-2023)
Abstract
Background: Multiple sclerosis disease (MS) is progressing, especially in women. The present study aimed to determine the effect of eight weeks of resistance training with two types of linear and nonlinear periodized on muscle strength, fatigue, and quality of life in women with MS.
Materials and Methods: A total of 19 patients with MS were selected and randomly assigned to three groups: nonlinear periodized (NLP) (n=6), linear periodized (LP) (n=5), and control (n=8). Both exercise groups performed resistance exercises three sessions a week for 30-45 minutes per session, with an intensity of 30%-70% of a maximum repetition for eight weeks. The linear group (LP) used a linear loading pattern per week. In contrast, the nonlinear group (NLP) experienced different intensities of training from the fourth week onwards. Two days before and after the training protocol, muscle strength was measured indirectly. Moreover, fatigue was evaluated with a 5-item Modified Fatigue Impact Scale (MFIS-5) and quality of life with a 36-Item Short Form Health Survey (SF-36). The results were analyzed in SPSS software (version 21) using the analysis of the covariance model and Fisher's least significant difference (LSD) post hoc test.
Results: Based on the results, LP and NLP training led to a marked increase in muscular strength )P<0.001) and a significant decrease in fatigue )P=0.020) in MS patients. Nonetheless, no significant difference was observed in the quality of life between research groups )P=0/092). There were no significant differences between LP and NLP in factors, except leg press )P<0/001).
Conclusion: As evidenced by the obtained results, both LP and NLP training models increased muscle strength and reduced fatigue. Nevertheless, linear resistance training led to greater improvement in the aforementioned factors.
