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Showing 4 results for Quercetin
Quercetin flavonoid and non-alcoholic fatty liver disease
Mohamad Hadi Emamat, Parvin Mirmiran, Azita Hekmatdoost,
Volume 18, Issue 1 (5-2016)
Abstract

Background: The prevalence of non-alcoholic fatty liver disease (NAFLD) increased globally. Prevalence of NAFLD in general population estimated as 10-24%. Insulin resistance and fat accumulation in liver cells playing an important role in this disease. Recently usage of antioxidants in prevention and treatment of disease is considered. Quercetin is an antioxidant in flavonoids group.  In the present study we aim to determine the effects of quercetin on NAFLD.

Materials and Methods: After searching relevant keywords such as NAFLD, antioxidant, quercetin, insulin resistance, liver activity, lipid and inflammation, 20 fulltext papers and 12 abstracts that which were in accordance with the aim of this study were evaluated.

Results: Quercetin in addition to its inherent antioxidant activity can reduce inflammation; improve serum lipids; decrease lipid accumulation in the liver; improve insulin resistance by increasing hexokinase activity, glycogen content of muscle and liver, phosphorylation and activation of insulin receptors; and promote liver activity by reducing serum liver transaminase enzymes and inhibiting the production of liver fibrotic factors.

Conclusion: In animal and cell-culture studies, the application of quercetin was shown to have antioxidant, anti-inflammatory, hypolipidemic, insulin resistance reduction and antifibrotic effects. All these factors clearly show that quercetin can be counted as one of the important dietary factors having a role in the prevention and also treatment of NAFLD.


Protective effect of quercetin on skeletal teratogenicity induced by experimental diabetes in rat fetus
Saeideh Heidarinejad, Mahmod Khaksary Mahabady , Reza Ranjbar, Hosein Najafzadeh Varzi, Babak Mohammadian,
Volume 18, Issue 4 (3-2017)
Abstract

Background : Maternal diabetes can induce a number of developmental abnormalities including deformities of the face and palate and these teratogenic effects decrease by application of antioxidant drugs. In this study, the prophylactic effect of quercetin on fetal teratogenesis incidence from diabetes was evaluated.

Materials and Methods: In this experimental study, 24 female Wistar rats were used into four groups. After intravenous injection of streptozotocin (50 mg/kg) and confirm of diabetes in 2 groups of rats, all rats were mated. One group of diabetic and non-diabetic rats received quercetin (75 mg/kg/ orally) in 0,7,14 and 20 days of gestation while two control groups received normal saline. Fetuses were collected at 20th day of gestation and after determination of weight and length were stained by Alizarin red - Alcian blue method and skeletal abnormalities was evaluated by stereomicroscope.

Results: Cleft palate, wavy rib and rib adhesion incidence were 38.09%, 4.86% and 14.28% range in control diabetic group but their incidence were respectively decreased 16.12%, 0% and 0% by quercetin. Also, quercetin decreased skeletal anomalies incidence including sternum, and ribs.

Conclusion: Quercetin as one antioxidant can decrease teratogenicity induced by diabetes mellitus.


Effect of Quercetin Solid Lipid Nanoparticles on Autophagy and Atg5 Protein Expression Levels in Human Breast Cancer Cell Line (MCF-7)
Firoozeh Niazvand, Laya Sadat Khorsandi, Forouzan Absalan, Atefeh Ashtari,
Volume 22, Issue 2 (8-2020)
Abstract
Background: Due to proven anti-tumor activity of quercetin (QT), however the low effectiveness of QT has restricted its use. This study aimed to assess the toxic effect of QT encapsulated in solid lipid nanoparticles (QT-SLNs) on the cell death (Autophagy) of MCF-7 human breast cancer cells.
 Materials and Methods: MCF-7 and MCF-10A (non-tumorigenic cell line) cell lines treated with 25 µml/mL of QT or QT-SLNs for 48 h. Cell viability and Autophagy were evaluated to determine the toxic effectiveness of the QT-SLNs.
Results: The QT-SLNs with appropriate characteristics were prepared. The QT-SLNs showed sustained QT release until 48 h. Cytotoxicity assessments indicated that QT-SLNs inhibited MCF-7 cells growth with a low IC50 (50% inhibitory concentration) value, compared to the free QT. QT-SLNs induced a significantly increased in Autophagy in the MCF-7 cells. Following QT-SLNs treatment, the expression of the ATG-5 protein significantly increased in comparison with free QT-treated cells. Furthermore, The QT-SLNs significantly increased autophagy indexes in MCF-7 cells. Viability and autophagy of MCF-10A cells were not affected by QT or QT-SLNs.
Conclusions: According to these results, SLN significantly enhanced the toxic effect of QT against human breast cancer cells.

Effect of Six Weeks of Aerobic Training with Quercetin Supplementation on the Expression of Mitochondrial AMPK and NRF-1 Genes in the Hippocampus of Diabetic Male Rats
Raha Mohammadi, Lotfali Bolboli, Mohammadjavad Pourvaghar, Roghayeh Afroundeh,
Volume 24, Issue 4 (3-2023)
Abstract
Background: The most common neurological complication of hyperglycemia is neuropathy which leads to changes in the central nervous system. Therefore, this study aimed to investigate the effect of six weeks of aerobic exercise with quercetin supplementation on the expression of mitochondrial Ampk and Nrf-1 genes in the hippocampus of diabetic male rats.
Materials and Methods: This experimental study was performed by the laboratory method. Thus, 35 male Wistar rats were divided into five groups (n=7): Healthy Control, Diabetes Control, Diabetes Exercise, Diabetes Exercise Quercetin Supplement, and Quercetin Supplement. During the course, the supplement and diabetic groups were injected with 15 mg/kg of quercetin per day after induction of diabetes. For the training groups, six weeks of moderate-intensity aerobic exercise was performed on a revolving bar. To evaluate the expression of mitochondrial Ampk and Nrf-1 genes, hippocampal tissue was isolated 24 h after the last training session. The SPSS statistical software (version 23), one-way analysis of variance (ANOVA), and Tukey's post hoc test onther significance level of  0.05 were used to analyze the collected data.
Result: The findings of this study showed that after six weeks of aerobic exercise, the expression of mitochondrial Ampk and Nrf-1 genes in the exercise supplement diabetes group significantly increased (P<0.05) compared to diabetes control, exercise diabetes, and quercetin supplementation. A significant increase was observed only for Ampk in the exercise diabetic group compared to the diabetic control and quercetin diabetic groups (P<0.05).
Conclusion: It seems that six weeks of aerobic exercise with quercetin supplementation can positively affect the expression of mitochondrial Ampk and Nrf-1 genes in hippocampal tissue and increase it in diabetic conditions.

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