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Showing 6 results for Testosterone
The effect of noise pollution on Pituitary-Gonadal hormones in male rat
Ghasem Saki , Sima Nasri, Maryam Jalali, Mohammad Reza Gholami ,
Volume 15, Issue 4 (1-2014)
Abstract
Background : Noise is a kind of environmental pollution affecting the life of humans. Many researches have been carried out on the effects of noise stress on the different parts of body, but few studies have been done on sexual systems. The aim of this study is to investigate the effects of noise stress on testosterone, LH and FSH. Materials and Methods: Two groups of ten male rats have been introduced to 2 noisy environments of experimental and ordinary (with intensity of 90-120 decibel and frequency of 300-350 HZ) for fifty days from 7 am to 7 pm. After 50 days blood samples were collected from tail and level of testosterone, LH and FSH measured by Eliza and results were interpreted using T test with a significance of p<0.05. Results: Statistical studies showed that the average of testosterone secretion, LH and FSH in comparison with control group, had a significant difference (p<0.05). Conclusion: On the whole it can be said that sonic stresses decrease the level of testosterone, LH and FSH.
The effect of combined exercise training on plasma Leptin levels and hormonal factors in overweight men
Saeed Emamdost, Mohamad Faramarzi , Laleh Bagheri , Khadije Otadi, Mohamad Amiri , Tahereh Yazdani ,
Volume 16, Issue 1 (6-2014)
Abstract

  Background: The purpose of this study was to determine the effect of a period of combined exercise training on the plasma leptin level and hormonal factors in overweight men.

  Materials and Methods: The subjects of this research consisted of thirty males (22-42 years old, BMI ≥29) who randomly were divided into experimental (n=15) and control groups(n=15). The experimental group performed for 8 weeks aerobic and resistance training, 3 sessions per week and each session included 10-12 station strength training at 75-70% of One Repetition Maximum (1RM) for the first 4 weeks and at 75-80% of 1RM for the second 4 weeks. At the end, 10 minutes aerobic runing training at 70-75% of MHR in the first 4 weeks and 13 minute at 75-80% of MHR in the second 4 weeks were conducted.

  Results: Leptin, body weight, Body Mass Index (BMI) and insulin significantly decreased after the training ((P<0.05). However, There were no significant differences in the serum levels of cortisol and testosteron after 8 weeks concurrent training. The ratio of testosteron to cortisol (T/C) in the experimental group showed a slight increase.

  Conclusion: Generally, it appears that decrease of leptin due to a period of combined exercise training is more associated with reduce of body fat, weight and BMI than the change of testosteron or cortisol. In contrast to most researches, it seems that combined exercise training is more effective.


The effect of intraperitoneally injection of Crystal meth on pituitary-gonad axis in adult male Rats
Homeira Hatami , Nazli Khajehnasiri,
Volume 17, Issue 2 (9-2015)
Abstract

Background: Psychostimulant amphetamine (Ecstasy and Crystal meth or n-methyl-1- phenyl-propan-2- amine) abuse has been prevalent among the youth of Iran in recant years. These substances have many adverse and destructive effects on several organs. Therefore, this study was done to determine the effect of crystal meth on pituitary-gonadal axis in adult male rats. Material and Methods: 28 male adult rats were divided into four groups normal control group, and 5, 10 and 15 mg/kg bw Crystal meth-treatment groups. Animals in the Crystal meth-treated groups received 5, 10 and 15 mg/kg bw of Crystal meth intraperitoneally for seven days. After 7 days, blood sample was taken from the left ventricle of the animal's heart and LH, FSH and testosterone concentration were measured using ELISA kit. The SPSS-16 statistical software was used to analyze data. All data were analyzed by one-way analysis of variance (ANOVA) and the differences were considered significant at the p<0.05 level. Results: Testosterone hormone concentration significantly increased in experimental groups (10 and 15 mg/kg bw) in comparison with control group (P<0.05). Concentrations of FSH and LH in the experimental groups (5, 10 and 15 mg/kg bw) significantly reduced in comparison with control group (P<0.05). Conclusion: According to the hormonal examinations, we concluded that the use of Crystal meth causes destructive effects on the male pituitary-gonadal axis.


Effect of alcoholic extract of olive leaves on Serum Level of FSH, LH and Testosterone fallowing renal ischemic- reperfusion injury in Male Rats
Mohamad Reza Nasirzadeh,
Volume 19, Issue 1 (6-2017)
Abstract

Background : In males, testosterone reduction is one of the complications of renal ischemia. Olive leaf is a significant source of bioactive phenolic compounds. They have better antioxidant capacity, anti-inflammatory and radical scavenging. The purpose of this study was to investigate the effect of olive leaf extract (OLE) on serum level of Gonadotropins and testosterone.

Materials and Methods: In this study forty – nine male rats were randomly divided into seven groups:1)control : which were intact animals 2)I/R 1h, 3)I/R1h+ OLE, 4)I/R 2h , 5)I/R 2h+ OLE),6) I/R 24h and 7) I/R24h+ OLE. The animals in 3,5and 7 groups received 100mg/kg olive leaf extract in 0.5 ml drinking water using gavages for 28 days. At the end of the treatment, levels of urea, Creatinin FSH, LH and testosterone were determined in serum.

Results: The results showed that serum urea and Creatinin level in the control group was significantly lower than other groups (P>0.05).also, revealed that serum level of testosterone in I/R 24h group significantly decreased in comparison with I/R24h+olive leaf extract group(P>0.05).

Conclusion: This study indicated that oral administration of olive leaf extract can prevent from testosterone reduce in I/R 24h group.


Relationship between the consumption of chronic methamphetamine on testosterone, LH and FSH among men’s
Somayeh Azadbakht, Faramarz Souri, Toraj Hasani Rad, Hosein Souri,
Volume 19, Issue 5 (2-2018)
Abstract

Background: Methamphetamine is simply made from available chemicals such as pseudoephedrine, this drug was previously used to treat ADHD, and a major contribution to controlling sexual acts in men and women is through the secretion of the GNRH gonadotropin hormone from the hypothalamus. This hormone enters the anterior pituitary through the portal vessels and secretes the LH and FSH hormone. The purpose of this study was to investigate the relationship between chronic methamphetamine consumption on testosterone, LH and FSH in males.
Materials and Methods: In this study, 30 men with chronic methamphetamine dose referred to health clinics in the city for the use of random sampling method and were assessed. The subjects completed the questionnaire of the Addiction Severity Index (ASI) and transferred to the laboratory after blood sampling.
Results: The results showed that the duration of taking methamphetamine does not affect the amount of FSH. There was no significant difference observed between different times. However, the amount of methamphetamine consumption affects the level of LH and testosterone levels.
Conclusion: Duration of taking methamphetamine has an effect on the level of LH and testosterone, but does not affect the FSH hormone.
 


Changes in Some Fitness Factors, Testosterone, and Cortisol Following Combined Exercise with and Without Blood Flow Restriction in Older Men
Mohsen Farhadiyani Asgarabadi, Nasser Behpoor, Ahmad Mohammadi Moghaddam,
Volume 24, Issue 1 (4-2022)
Abstract
Background: Considering the importance of maintaining and promoting the health of the elderly, it is necessary to examine their hormonal responses during physical fitness exercises. This study aimed to investigate the effect of two combined training methods with and without blood flow restriction on some physical fitness (muscle strength and muscle endurance), anabolic (testosterone), and catabolic (cortisol) factors.
Materials and Methods: The present research was quasi-experimental with a pretest-posttest design. A total of 24 elderly men with no history of training participated in this study voluntarily. They were divided randomly into two experimental groups and one control group. Measurement included the 30-second sit-up test, the sit-up test with 50% of one-repetition maximum (to the point of fatigue), testosterone level, and cortisol level. In the group with blood flow restriction, both upper thighs were closed with cuffs and the exercise was performed with the intensity of 20-30% of 1RM, to the point of fatigue. In the training group without restriction, the same movements were performed with an intensity of 65- 80% of 1RM, to the point of fatigue. The covariance test and Bonferroni post hoc test were used to analyze the data.
Results: The results showed that training with blood flow restriction had a significant effect on increasing muscle strength and muscle endurance similar to that caused by high-intensity training without blood flow restriction. Moreover, the results of the study on the effect of exercise with and without vascular occlusion on testosterone and cortisol levels showed that both training methods had similar effects on increasing testosterone levels and decreasing serum cortisol levels in older men.
Conclusion: Since heavy weight training is difficult and risky for the elderly, they can effectively practice low-intensity resistance exercises with blood flow restriction. Eventually, the study of other hormonal and neuromuscular mechanisms involved in the effectiveness of these exercises will expand knowledge in this field of study.


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