Showing 3 results for Oxytocin
Mohammad Reza Rafiei, Mansoure Samimi, Mehdi Noroldini, Seyed Gholam Abbas Mosavi,
Volume 8, Issue 1 (6-2006)
Abstract
Background: Uterine bleeding is an important side effect of cesarean section which
is due to non contractile uterine. The aim of this study was to compare the effect of
10% dextrose (IV infusion) and 40 IU/L oxytocin (IV infusion) on uterine contraction.
Materials and Methods: This research was a double-blinded randomized clinical
trial (RCT) study. 120 women were equally included in the two study groups. After
cesarean section and uterine bleeding due to non contractile uterine, each patient
randomly received 10% dextrose or 40 IU/L oxytocin in equal volume, intravenously.
The ability of these two drugs to induce firm contraction of the uterine muscle was
then determined.
Findings: There was significant difference between the ability of the two drugs to
induce firm contraction of uterine muscle. The rate of firm contraction of uterine
muscle in response to IV infusion of 10% dextrose was 68.3% and to IV infusion of
40 IU/L oxytocin was 31.7% (P < 0.01). IV infusion of 10% dextrose affected high
parity women more intensely (82.4% compare to 12.5%) and IV infusion of 40 IU/L
oxytocin had a more intense effect on low parity women (63.6% compare to 43.5%)
(P> 0.05).
Conclusion: IV infusion of 10% dextrose is more effective than IV infusion of 40
IU/L oxytocin on uterine bleeding and firm contraction of uterine muscle after
cesarean section in the women.
Fahimeh Sehhati , Vahideh Firouzan , Lida Heidari , Mohammad Bagher Hosaini , Morteza Gojezadeh,
Volume 10, Issue 1 (4-2008)
Abstract
Abstract Background: Insufficient uterine activity or hypotonic uterine contraction is a common reason and the cause of abnormal labor progress that can be corrected with oxytocin. Realizing this fact that undue prolongation of labor may contribute to prenatal morbidity has resulted in using oxytocin infusion in different kinds of ineffective uterine contractions. Materials and methods: In this study, one hundred pregnant women in 29 Bahman hospital participated in a quasi-experimental research and were divided randomly into 2 groups of pulsatile induction as well as continuous induction and were compared in terms of pregnancy outcomes including progress of labor, hyperstimulation, mood of delivery, third stage duration, newborn’s Apgar score, and hyperbilirobinemia. Results: There were no significant differences between the two groups in progress of labor, hyperstimulation rate, newborn’s Apgar score, and hyperbilirobinemia (p>0.05) however, significant differences were observed in labor duration (p=0.022), mood of delivery (p=0.008), and dose of oxytocin (p<0.0005). Conclusion: According to the findings of this study, administration of oxytocin with the feedback pulsatile oxytocin system is easier and more physiologic to establish the effective uterine contraction and reduces duration of labor and cesarean section rate. Moreover, the average dose of oxytocin administered is significantly less in the pulsatile induction group.
Parvin Asti , Sohela Akbari , Mojghan Masoudi , Khatereh Anbari ,
Volume 16, Issue 4 (2-2015)
Abstract
Background: Medical interventions in labor have been common in recent years. Oxytocin is amongst them which is used to speed delivery. Unfortunately the indiscriminate administration of it could lead to maternal and infant complications. The aim of this study was to compare labor outcome with oxytocin and spontaneous delivery in low risk pregnant women. Materials and Methods: In this descriptive – comparative study, 395 women with single fetus, cephalic presentation, normal delivery, in the active phase of labor were selected. 197 of the cases, as Oxytocin group, received oxytocin by physician,s order during their labor and 198 of the samples, as the second group, had spontaneous vaginal delivery. In both groups, some of the maternal and neonatal outcomes including: maternal morbidity , Apgar score at minutes one and five, admitted in neonatal intensive care unit and were studied.Data were analyzed using SPSS 16, t-test, Chi-square and Mann Whitney tests. Results: The findings showed that oxytocin significantly increased rates of episiotomy, laceration, post partum hemorrhage, hospitalization of neonate in intensive care unit and reduction of Apgar score at minutes one and five that were statistically significant (p <0.05). Conclusion: The results showed that the acceleration of delivery is not a safe method and increases the rate of maternal and infant complications. Therefore, it should be used in the case of medical necessities.
