Volume 7, Issue 1 (1-2006)
yafte 2006, 7(1): 4-11 |
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Esmaili dehaj M, Delfan B, Meshkato sadat M H, Alaei H, Tevakoli A, Shahsavari G et al . Steroidal alkaloids isolated from leaf (olea Europaea) decreased cerebral ischemic – induced inury on rats. yafte 2006; 7 (1) :4-11
URL: http://yafte.lums.ac.ir/article-1-1062-en.html
URL: http://yafte.lums.ac.ir/article-1-1062-en.html
Mansour Esmaili dehaj * 
, Bahram Delfan , Mohamad hadi Meshkato sadat , Hojatollah Alaei , Asadollah Tevakoli , Gholamreza Shahsavari , Mohammad javad Tarahi
, Bahram Delfan , Mohamad hadi Meshkato sadat , Hojatollah Alaei , Asadollah Tevakoli , Gholamreza Shahsavari , Mohammad javad Tarahi
Abstract: (13081 Views)
Background: The steroidal alkaloids incurring great interest because of their
various pharmacological properties that isolated from various species. The aim of this
investigation has been to studying of the effects of Steroidal alkaloids isolated from
olive leaf on cerebral ischemic – induced inury on rats.
Materials and methods: In this experimental study, 48 male wistar rats divided to
six groups of eight. Then cerebral ischemia- reperfusion injury produced by 10 min
bilateral occlusion of the common carotid and vertebral artery, followed by 5 day
reperfusion.
Findings: Intravenous setroidal alkaloids isolated from olive leaf (0.5 , 1 , 1.5 mg.kg)
markdly reduced the stroke index, enhanced the recovery of EEG
(Electroencephalogram) amplitude during reperfusion and decreased the concentration
of cortex calcium and LPO (lipid peroxidase) in a dose dependent manner. However,
no significant effects on water and sodium contents were observed .
Conclusions: These results suggested that steroidal alkaloids exhibited protective
effects on cerebral ischemia – reperfusion injury in rats, and its mechanism might be
related to reducing calcium accumulation and lipid peroxidation
Keywords: Steroidal alkaloids, Cerebral ischemia-reperfusion, Electroencephalogram, Lipid peroxidase
Type of Study: Research |
Received: 2013/01/22 | Accepted: 2021/10/13 | Published: 2006/01/15
Received: 2013/01/22 | Accepted: 2021/10/13 | Published: 2006/01/15
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