Volume 15, Number 5 (3-2014)                   yafte 2014, 15(5): 5-12 | Back to browse issues page


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shahsavar F, Sabooteh T, Jafarzadeh M. Distribution of ApoE polymorphisms in the Lur population. yafte. 2014; 15 (5) :5-12
URL: http://yafte.lums.ac.ir/article-1-1488-en.html

MSc of Immunology Research Center
Abstract:   (3452 Views)
Background: Apolipoprotein E (ApoE) contributes to susceptibility to many different kinds of diseases. The aim of this study was genotypic analysis of ApoE in the Lur population for the first time. Materials and Methods: In this study, 100 unrelated healthy Lur individuals were ApoE polymorphisms typed by polymerase chain reaction based restriction fragment length polymorphism (PCR-RFLP). Finally, the allele and genotype frequency of ApoE polymorphisms in the Lur population was compared with the Iranian population. Results: Six ApoE genotypes and all of the ApoE polymorphisms were observed in the Lur population. genotype with the frequency of 48% was the most frequent genotype in the Lur population. Also, the most common allele in the Lur population was . Conclusion: The results indicate that the frequency of ApoE polymorphisms has total similar features reported in the Iranian population, but it is still unique by increasing or decreasing some frequencies in the Lur population.
Full-Text [PDF 193 kb]   (924 Downloads)    
Type of Study: Research |
Received: 2014/03/1 | Accepted: 2014/03/1 | Published: 2014/03/1

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