Volume 16, Number 3 (1-2015)                   yafte 2015, 16(3): 85-92 | Back to browse issues page


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Seyed Alipour B, Oshrieh M, Khanbabaee R. The effect of ZnO Nps of 20 nm on changes of enzyme and liver tissues of pregnant NMRI mice. yafte. 2015; 16 (3) :85-92
URL: http://yafte.lums.ac.ir/article-1-1747-en.html

Assistant Professor, Department of Cellular and Molecular Biology Faculty of Basic Sciences, University of Mazandaran, Babolsar, Iran, b.alipour81@gmail.com
Abstract:   (1735 Views)
Background :Nowadays, nanotechnology has been developing rapidly and may have considerable effects on industry, society and the environment. In this research the toxicity properties of zinc oxide nanoparticles with a size of 20 nm on enzyme and liver tissue of NMRI mice were studied. Materials and Methods: This experimental study was performed in standard conditions on 25 NMRI mice with an average weight of 30 ± 3 g so that they received different doses of zinc oxide nanoparticles, an a days, for 15 days intraperitoneally. Then, blood samples were taken on day 17 of NMRI mice. The collected tissues were washed with saline and fixed in Boin΄s fluied buffer and stained with hematoxylin and eosin for histopathology evaluation. After data collection, statistical analysis was done using SAS software. Results: The results showed that activity of ALT enzyme at concentrations 50, 100, 150 and 200 mg/kg ZnO Nps at a significant level (p<0.05) increased in comparison with the control group. Histopathological investigation showed that zinc oxide nanoparticles caused severe damage in liver. Damaged liver cells develop leaky membranes and escape of intracellular enzymes into the bloodstream. Conclusion: Our findings showed that using different concentration of zinc oxide nanoparticles could be caused undesirable effects on liver with damage to hepatocyte and level elevation of liver enzymes.
Full-Text [PDF 262 kb]   (785 Downloads)    
Type of Study: Research |
Received: 2014/12/28 | Accepted: 2014/12/28 | Published: 2014/12/28

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