Volume 18, Number 2 (9-2016)                   yafte 2016, 18(2): 92-97 | Back to browse issues page


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NiyaPak S, Ghadiri A, Ghaforiyan Broujerdniya M, Hakimzadeh M. A comparision of intestinal biopsies and serologic anti-tissue transglutaminase in children with seliac disease in Ahvaz city in 2015. yafte. 2016; 18 (2) :92-97
URL: http://yafte.lums.ac.ir/article-1-2304-en.html

MSc of Immunology Faculty of Medicine, Jundishapur University of Medical Sciences, Ahvaz, Iran
Abstract:   (522 Views)

Background: CD or gluten-sensitive enteropathy is caused by dietary gluten ingestion in geneticallysusceptible individuals.The aim of the study was to compare the current diagnostic methods of CD and relationship between these methods.

Material and Method: In this study 50 patients suspicious to have celiac disease were studied. After IgA anti-TTG test using Eliza method, the patients went under upper endoscopy, then  histopathologic findings were grouped by Marsh classification.

Results:  Fifty patients, 23 males and 27 females with mean age of 8.36 were included in the study. TTG-IgA test was positive in 45 patients. Most pattients were categorized as Marsh stage III ( 28 cases) by histopathologic examination, which can be seen in other studies. We found significant correlation between histopathologic and serologic findings (p-valu=0.014). no significant correlation was found between histopathological test and patients age.

Conclusion: Based on the results obtained in this study between histopathologic findings and serologic findings were significant relationship, The diagnostic approach presented in this study may also be useful in the assessment of CD. In the end, for a definitive diagnosis of celiac disease, molecular tests and also determination of haplotype HLADQ are recommended

Full-Text [PDF 226 kb]   (369 Downloads)    
Type of Study: Research |
Received: 2016/09/7 | Accepted: 2016/09/7 | Published: 2016/09/7

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