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Mirrezaee N, Dakhili M, Mehrpour S. Effects of antifungal Rue on the candida albicans isolated from patients with vaginitis on in vitro during spring and winter seasons and comparison with two antibiotics. yafte. 2017; 19 (2) :50-59
URL: http://yafte.lums.ac.ir/article-1-2544-en.html

Background : Fungi  resistance to antifungal agents is one of the most common problems in medicine. Herbal remedies increased use in the traditional medicine an interesting and unexplored source of assessing new drug. Some plant essential oils, including Rue   (Rue officinalis L)  have anti– fungaleffects and they can be used as antimicrobial agents in treatment of infections. Hence, the aim of this study was to evaluate the compounds of essential oil and the anti – microbial properties of  its essential oil.

Materials and Methods: In this experimental study, Ruta graveolens of Agriculture Research Center in Qom were collected . The essential oils were extracted, the inhibitory zone diameter and minimum inhibitory concentration (MIC) and minimum fungicidal concentration (MIC, MFC), 140 candida isolates from patients referred to the clinic in women.

Results: The mean inhibition in the disk diffusion method essential oils and ethanol extract  in the spring on the isolates, 19.71± 2.50 mm and 16.19 ± 1.9 mm  were respectively, and in the winter 21.16 ±3.7mm  and 18.32± 2.2 mm, respectively.
Conclusion: The results of this study, Rue  essential oil and extract on candida albicans inhibitory effect .