Volume 21, Issue 1 (5-2019)                   yafte 2019, 21(1): 63-74 | Back to browse issues page

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Soltani R, Kordi M R, Gaeini A A, Nuri R. The effects of 8 weeks aerobic training on HIF-1α, miR-21 and VEGF gene expression in female Balb/c with breast cancer . yafte. 2019; 21 (1) :63-74
URL: http://yafte.lums.ac.ir/article-1-2760-en.html
Department of Exercise Physiology, Tehran university, Tehran, Iran
Abstract:   (71 Views)
Background: Breast cancer, which is a major cancer for women, affects the angiogenesis process. Exercise training can decrease the process of angiogenesis in tumor tissue. The aim of present study was to investigate the effects of 8 weeks of aerobic training on HIF-1α, miR-21 and VEGF gene expression in female Balb/c mice with breast cancer.
Materials and Methods: 16 female Balb/c mice (age: 3-5 weeks and weight: 17/1 ± 0.1 g) were selected and randomly divided into two groups: aerobic training and control. The aerobic training involved running with intensity of 14-20 m/min for 5 sessions per week over 8 weeks. The gene expression of HIF-1α, miR-21 and VEGF was examined by RT&PCR. The repeated measurement ANOVA, Bonferroni post hoc test and the independent T-test were used to analyse the data, with a significant level set at p<0.05.
Results: The results showed that aerobic training induced significant differences in the growth of tumor volume and an increase in HIF-1α. In addition, aerobic training caused a significant decrease in the gene expression of miR-21, whereas the changes in gene expression of VEGF were not significant.
Conclusion: It appears that aerobic training caused a reduction in the gene expression of miR-21 and VEGF, which in turn, induced a decrease in the tumor volume and a corresponding improvement in the cancer
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Type of Study: Research | Subject: فیزیولوژی انسانی
Received: 2018/10/20 | Accepted: 2019/02/16 | Published: 2019/06/8

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