Volume 23, Issue 4 (9-2021)                   yafte 2021, 23(4): 133-148 | Back to browse issues page

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Rouzbehan B, AbedNatanzii H, Ebrahim K, Ghazalian F. The effect of aerobic training and pomegranate juice on serum levels of some microRNAs related to the oxidant/antioxidant system in women recovering from breast cancer. yafte. 2021; 23 (4) :133-148
URL: http://yafte.lums.ac.ir/article-1-3179-en.html
Department of Professional Physical Education and Sports Sciences, Science and Research Branch, Islamic Azad University, Tehran, Iran
Abstract:   (309 Views)
Background: Breast cancer is one of the most common cancers and the first leading cause of cancer death (25.5%) among women across the world. Oxidative stress and overproduction of free radicals are among the most important reasons for the progression of cancers. This study aimed to investigate the effect of eight weeks of aerobic exercise with pomegranate juice on Serum microRNAs levels related to the oxidant/antioxidant system of women recovering from breast cancer.
Materials and Methods: In this semi-experimental study, 40 women recovering from breast cancer with a mean age of 42.45±1.95 were randomly assigned into four equal groups (n=10), including control, pomegranate juice, aerobic exercise, and aerobic-pomegranate. The aerobic and aerobic-pomegranate groups performed eight 60-90-min sessions of exercises three times a week with an intensity of 50% to 70% of the target heart rate. The pomegranate juice group received 100 cc of juice before each training session. Blood samples were collected 48 h before and after the intervention. Oncogenic microRNAs, such as miR-21 and miR-155, were assayed by RT-PCR. The obtained data were analyzed using one-way ANOVA, ANCOVA, and Bonferroni post hoc test at a significance level of P≤0/05.
Results: In total, eight weeks of aerobic exercise with the consumption of pomegranate juice caused a significant decrease in miR-21 (P=0.001) and miR-155 (P=0.001) levels in women recovering from breast cancer, compared to the control group.
Conclusion: Aerobic exercise and consumption of pomegranate juice simultaneously reduced oncogene microRNAs, such as miR-21 and miR-155, in women recovering from breast cancer.
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Type of Study: Research | Subject: زنان
Received: 2021/02/17 | Accepted: 2021/08/9 | Published: 2021/11/10

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