Background: Many studies have shown that vascular stromal cell injection can lead to skin repair; however, there is limited information about the effects of vascular stromal cell injection on the improvement of peri-ocular aging. Based on this, the present study investigated the effects of vascular stromal cell injection of autologous adipose tissue on the treatment of aging around the eyes. Materials and Methods: In this clinical trial, cells were injected subcutaneously into middle-aged people with aging around the eyes. Data were analyzed in SPSS 25 software using t-test and ANOVA. Results: The results of this study indicated that the injection of vascular stromal cells significantly reduced the volume and area of wrinkles around the eyes (P<0.05). Furthermore, individuals aged 44 and 45 showed the greatest improvement in signs of eye aging compared to other age groups. Conclusion: In conclusion, it can be stated that the injection of vascular stromal cells has a significant impact on the repair and improvement of aging signs in the periocular area. This method also shows the potential to become an effective clinical and therapeutic approach for skin rejuvenation and the reduction of wrinkles around the eyes.
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